Caspase-Dependent Apoptosis

Any apoptotic process that involves pathways that activate intracellular proteolytic caspases.
National Institutes of Health

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BOK geneBOK wt AlleleBcl-2-Related Ovarian Killer ProteinCARD11 gene
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Papers overview

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2015
2015
Induction of caspase-dependent extrinsic apoptosis by apigenin through inhibition of signal transducer and activator of transcription 3 (STAT3) signalling in HER2-overexpressing BT-474 breast cancer…
Phytoestrogen intake is known to be beneficial to decrease breast cancer incidence and progression. But its molecular mechanisms… (More)
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2014
2014
A Caspase-Dependent Pathway Is Involved in Wnt/β-Catenin Signaling Promoted Apoptosis in Bacillus Calmette-Guerin Infected RAW264.7 Macrophages
Apoptosis of alveolar macrophages following Mycobacterium tuberculosis infection have been demonstrated to play a central role in… (More)
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2013
2013
Polyphenols isolated from Allium cepa L. induces apoptosis by suppressing IAP-1 through inhibiting PI3K/Akt signaling pathways in human leukemic cells.
Allium cepa Linn is commonly used as supplementary folk remedy for cancer therapy. Evidence suggests that Allium extracts have… (More)
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2010
2010
Compound K, a Metabolite of Ginseng Saponin, Induces Mitochondria-Dependent and Caspase-Dependent Apoptosis via the Generation of Reactive Oxygen Species in Human Colon Cancer Cells
The objective of this study was to elucidate the cytotoxic mechanism of Compound K, with respect to the involvement of reactive… (More)
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2009
2009
Cell cycle arrest in early mitosis and induction of caspase-dependent apoptosis in U937 cells by diallyltetrasulfide (Al2S4)
Naturally occurring organic sulfur compounds (OSCs), such as linear allylsulfides from Allium species, are attracting attention… (More)
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2009
2009
Polypyrimidine tract binding proteins (PTB) regulate the expression of apoptotic genes and susceptibility to caspase-dependent apoptosis in differentiating cardiomyocytes
Cardiac morphologic abnormalities in mice deficient for key regulators of the caspase-dependent signaling underscored its role in… (More)
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2006
2006
Granzyme M directly cleaves inhibitor of caspase-activated DNase (CAD) to unleash CAD leading to DNA fragmentation.
Granzyme (Gzm)M is constitutively highly expressed in NK cells that may play a critical role in NK cell-mediated cytolysis… (More)
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Review
2003
Review
2003
The apoptosis-necrosis continuum: insights from genetically altered mice.
Apoptosis can be defined as a carefully regulated process, characterized by specific morphologic and biochemical features. It is… (More)
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Highly Cited
2002
Highly Cited
2002
Identification of novel isoforms of the BH3 domain protein Bim which directly activate Bax to trigger apoptosis.
Bim (Bcl-2-interacting mediator of cell death) is a member of the BH3 domain-only subgroup of Bcl-2 family members, for which… (More)
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2002
2002
A death-associated protein kinase (DAPK)-interacting protein, DIP-1, is an E3 ubiquitin ligase that promotes tumor necrosis factor-induced apoptosis and regulates the cellular levels of DAPK.
Death-associated protein kinase (DAPK) is a multi-domain Ser/Thr protein kinase with an important role in apoptosis regulation… (More)
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