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CD127 expression inversely correlates with FoxP3 and suppressive function of human CD4+ T reg cells
TLDR
It is found that the IL-7 receptor (CD127) is down-regulated on a subset of CD4+ T cells in peripheral blood and can be used to quantitate T reg cell subsets in individuals with type 1 diabetes supporting the use of CD127 as a biomarker for human T reg cells. Expand
CD28/B7 system of T cell costimulation.
TLDR
This review summarizes the state of CD28/B7 immunobiology both in vitro and in vivo; summarizes the many experiments that have led to the current understanding of the participants in this complex receptor/ligand system; and illustrates the current models for CD28-mediated T cell and B cell regulation. Expand
B7/CD28 costimulation is essential for the homeostasis of the CD4+CD25+ immunoregulatory T cells that control autoimmune diabetes.
TLDR
The results suggest that the CD28/ B7 costimulatory pathway is essential for the development and homeostasis of regulatory T cells that control spontaneous autoimmune diseases. Expand
CTLA-4 can function as a negative regulator of T cell activation.
TLDR
Results suggest that the MAb may obstruct the interaction of CTLA-4 with its natural ligand and block a negative signal, or directly signal T cells to down-regulate immune function. Expand
Innate immunity and intestinal microbiota in the development of Type 1 diabetes
TLDR
It is found that MyD88 deficiency changes the composition of the distal gut microbiota, and that exposure to the microbiota of specific pathogen-free MyD 88-negative NOD donors attenuates T1D in germ-free NOD recipients. Expand
The NOD mouse: a model of immune dysregulation.
TLDR
In this review, many of the important features of disease development and progression in the NOD strain are summarized, emphasizing the role of central and peripheral tolerance mechanisms that affect diabetes in these mice. Expand
Instability of the transcription factor Foxp3 leads to the generation of pathogenic memory T cells in vivo
TLDR
Analysis of the T cell receptor repertoire suggested that exFoxp3 cells developed from both natural and adaptive Treg cells, suggesting the generation of potentially autoreactive effector T cells as a consequence of Foxp3 instability has important implications for understanding autoimmune disease pathogenesis. Expand
Visualizing regulatory T cell control of autoimmune responses in nonobese diabetic mice
TLDR
Two-photon laser-scanning microscopy is used to analyze lymph node priming of diabetogenic T cells and to delineate the mechanisms of Treg cell control of autoimmunity in vivo, supporting the idea that dendritic cells are central to T Reg cell function in vivo. Expand
Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4.
TLDR
The phenotype of the CTLA-4-deficient mouse strain implies a critical role for CTla-4 in down-regulating T cell activation and maintaining immunologic homeostasis. Expand
The Foxp3+ regulatory T cell: a jack of all trades, master of regulation
TLDR
The versatility and adaptability of the Foxp3+ Treg cells may in fact be the best argument that these cells are 'multitalented masters of immune regulation'. Expand
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