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Rap1A positively regulates T cells via integrin activation rather than inhibiting lymphocyte signaling
TLDR
It is found that, far from playing an inhibitory role during T cell activation, Rap1A positively influences T cells by augmenting lymphocyte responses and directing integrin activation. Expand
Selection of the T cell repertoire.
TLDR
Interactions during thymocyte maturation that define the T cell repertoire are focused on, with an emphasis placed on current literature within this field. Expand
Duration of TCR stimulation determines costimulatory requirement of T cells.
TLDR
Using mice deficient for an important costimulatory molecule, CD28, it is shown that a transient signal-1 alone, either through infection with an abortively replicating virus, or through injection of viral peptide, anergizes CD8+ T cells, demonstrating the biological relevance of T cell anergy in vivo. Expand
Platelets regulate lymphatic vascular development through CLEC-2-SLP-76 signaling.
TLDR
It is demonstrated that platelets regulate lymphatic vascular development by directly interacting with lymphatic endothelial cells through C-type lectin-like receptor 2 (CLEC-2) receptors, identifying platelets as the cell type in which SLP-76 signaling is required to regulate lymphatics vascular development. Expand
Klf2 is an essential regulator of vascular hemodynamic forces in vivo.
TLDR
It is shown that Klf2 expression during development mirrors the rise of fluid shear forces, and that endothelial loss of Klf1 results in lethal embryonic heart failure due to a high-cardiac-output state, and it is suggested that hemodynamic regulation in response to fluidShear stress is required for cardiovascular development and function. Expand
Regulation of Blood and Lymphatic Vascular Separation by Signaling Proteins SLP-76 and Syk
TLDR
A hematopoietic signaling pathway required for separation of the two major vascular networks in mammals is revealed, and blood-lymphatic connections lead to embryonic hemorrhage and arteriovenous shunting. Expand
Transcription factor KLF2 regulates the migration of naive T cells by restricting chemokine receptor expression patterns
TLDR
It is concluded that KLF2 maintains proper T cell migration patterns by linking T cell movement and transcriptional regulation of chemokine receptor expression patterns. Expand
Positive and negative thymocyte selection induced by different concentrations of a single peptide.
TLDR
Low concentrations of the viral peptide antigen recognized by this transgenic TCR can mediate positive selection, whereas high concentrations result in thymocyte tolerance, and these findings support the affinity-avidity model of thymocytes selection. Expand
Tumor necrosis factor receptor p55 mediates deletion of peripheral cytotoxic T lymphocytes in vivo
TLDR
The results show a marked expansion and prolonged persistence of functional activated cytotoxic T cells in mice lacking the tumor necrosis factor (TNF) receptor p55, and conclude that the TNF receptor p 55 is involved in peripheral T cell deletion in vivo. Expand
Syk and Slp-76 mutant mice reveal a cell-autonomous hematopoietic cell contribution to vascular development.
TLDR
It is demonstrated that expression of GFPSlp-76 in a subset of hematopoietic cells rescues this phenotype, and that deficient cells confer focal vascular phenotypes in chimeric embryos consistent with a cell-autonomous mechanism. Expand
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