T-Cell Differentiation in the Thymus

Known as: thymocyte differentiation, thymocyte cell differentiation, T cell differentiation in thymus 
The progression of T cell precursors in the thymus through many stages of maturation. These stages include regulated expression of the alpha and beta… (More)
National Institutes of Health

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ACKR2 geneCCBP2 protein, humanCCBP2 wt AlleleCCL17 gene
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Thymic T-Cell Selectionimmature T cell proliferation in thymus

Papers overview

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Highly Cited
2008
Highly Cited
2008
A two-step process for thymic regulatory T cell development.
Recognition of self-antigens is required for regulatory T (Treg) cells to exert dominant tolerance. However, the mechanism by… (More)
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Highly Cited
2003
Highly Cited
2003
Essential role for caspase 8 in T-cell homeostasis and T-cell-mediated immunity.
Defects in death receptor-mediated apoptosis have been linked to cancer and autoimmune disease in humans. The in vivo role of… (More)
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Highly Cited
2000
Highly Cited
2000
Function of PI3Kgamma in thymocyte development, T cell activation, and neutrophil migration.
Phosphoinositide 3-kinases (PI3Ks) regulate fundamental cellular responses such as proliferation, apoptosis, cell motility, and… (More)
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Review
2000
Review
2000
Glucocorticoids in T cell development and function*.
Glucocorticoids are small lipophilic compounds that mediate their many biological effects by binding an intracellular receptor… (More)
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Highly Cited
2000
Highly Cited
2000
Constitutive activation of NF-kappaB and T-cell leukemia/lymphoma in Notch3 transgenic mice.
The multiplicity of Notch receptors raises the question of the contribution of specific isoforms to T-cell development. Notch3 is… (More)
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Highly Cited
1996
Highly Cited
1996
Transcription factor GATA-3 is required for development of the T-cell lineage
THE zinc-finger transcription factor GATA-3 is expressed in haematopoietic cells and in the developing kidney and nervous system1… (More)
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Highly Cited
1995
Highly Cited
1995
An HMG-box-containing T-cell factor required for thymocyte differentiation
Two candidate genes for controlling thymocyte differentiation,T-cellfactor-1 (Tcf-1) and lymphoid enhancer-binding factor (Lef-1… (More)
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Highly Cited
1992
Highly Cited
1992
Mutations in T-cell antigen receptor genes α and β block thymocyte development at different stages
Analysis of mice carrying mutant T-cell antigen receptor (TCP) genes indicates that TCP-β gene rearrangement or expression is… (More)
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Highly Cited
1992
Highly Cited
1992
Mutations in T-cell antigen receptor genes alpha and beta block thymocyte development at different stages.
Analysis of mice carrying mutant T-cell antigen receptor (TCR) genes indicates that TCR-beta gene rearrangement or expression is… (More)
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Highly Cited
1988
Highly Cited
1988
Developmentally ordered appearance of thymocytes expressing different T-cell antigen receptors
The T-cell repertoire is elaborated by a still poorly understood process during which precursor cells arising in the bone marrow… (More)
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