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T-Cell Differentiation in the Thymus

Known as: thymocyte differentiation, thymocyte cell differentiation, T cell differentiation in thymus 
The progression of T cell precursors in the thymus through many stages of maturation. These stages include regulated expression of the alpha and beta… Expand
National Institutes of Health

Related topics

Related topics

27 relations
ACKR2 geneCCBP2 protein, humanCCBP2 wt AlleleCCL17 gene
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Narrower (2)

Thymic T-Cell Selectionimmature T cell proliferation in thymus

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2002
Highly Cited
2002
Gene expression signatures define novel oncogenic pathways in T cell acute lymphoblastic leukemia.
Human T cell leukemias can arise from oncogenes activated by specific chromosomal translocations involving the T cell receptor… Expand
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Highly Cited
2000
Highly Cited
2000
Function of PI3Kgamma in thymocyte development, T cell activation, and neutrophil migration.
Phosphoinositide 3-kinases (PI3Ks) regulate fundamental cellular responses such as proliferation, apoptosis, cell motility, and… Expand
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Highly Cited
2000
Highly Cited
2000
PKC-θ is required for TCR-induced NF-κB activation in mature but not immature T lymphocytes
Productive interaction of a T lymphocyte with an antigen-presenting cell results in the clustering of the T-cell antigen receptor… Expand
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Review
2000
Review
2000
Glucocorticoids in T cell development and function*.
Glucocorticoids are small lipophilic compounds that mediate their many biological effects by binding an intracellular receptor… Expand
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Highly Cited
1999
Highly Cited
1999
Deficient T cell fate specification in mice with an induced inactivation of Notch1.
Notch proteins are cell surface receptors that mediate developmental cell specification events. To explore the function of murine… Expand
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Highly Cited
1999
Highly Cited
1999
Defective thymocyte maturation in p44 MAP kinase (Erk 1) knockout mice.
The p42 and p44 mitogen-activated protein kinases (MAPKs), also called Erk2 and Erk1, respectively, have been implicated in… Expand
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Highly Cited
1996
Highly Cited
1996
Transcription factor GATA-3 is required for development of the T-cell lineage
THE zinc-finger transcription factor GATA-3 is expressed in haematopoietic cells and in the developing kidney and nervous system1… Expand
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Highly Cited
1993
Highly Cited
1993
Mice deficient for the 55 kd tumor necrosis factor receptor are resistant to endotoxic shock, yet succumb to L. monocytogenes infection
The multiple biological activities of tumor necrosis factor (TNF) are mediated by two distinct cell surface receptors of 55 kd… Expand
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Highly Cited
1992
Highly Cited
1992
Profound block in thymocyte development in mice lacking p56lck
THE protein Lck (p56lck) has a relative molecular mass of 56,000 and belongs to the Src family of tyrosine kinases1–3. It is… Expand
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Highly Cited
1992
Highly Cited
1992
Mutations in T-cell antigen receptor genes α and β block thymocyte development at different stages
Analysis of mice carrying mutant T-cell antigen receptor (TCP) genes indicates that TCP-β gene rearrangement or expression is… Expand
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