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T-Cell Differentiation in the Thymus
Known as:
thymocyte differentiation
, thymocyte cell differentiation
, T cell differentiation in thymus
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The progression of T cell precursors in the thymus through many stages of maturation. These stages include regulated expression of the alpha and beta…
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National Institutes of Health
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Related topics
Related topics
27 relations
ACKR2 gene
CCBP2 protein, human
CCBP2 wt Allele
CCL17 gene
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Narrower (2)
Thymic T-Cell Selection
immature T cell proliferation in thymus
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
1999
Highly Cited
1999
Expression of the p56lckY505F Mutation in CD45-Deficient Mice Rescues Thymocyte Development
J. Seavitt
,
L. White
,
K. Murphy
,
D. Loh
,
R. Perlmutter
,
M. Thomas
Molecular and Cellular Biology
1999
Corpus ID: 6994108
ABSTRACT Mice deficient in the transmembrane protein tyrosine phosphatase CD45 exhibit a block in thymocyte development. To…
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Review
1998
Review
1998
Molecular and cellular events in early thymocyte development.
H. Rodewald
,
H. Fehling
Advances in Immunology
1998
Corpus ID: 10498029
Review
1998
Review
1998
In vivo roles of receptor tyrosine kinases and cytokine receptors in early thymocyte development.
J. P. Santo
,
H. Rodewald
Current Opinion in Immunology
1998
Corpus ID: 36209075
Highly Cited
1996
Highly Cited
1996
Interleukin-7 is a critical growth factor in early human T-cell development.
J. Plum
,
M. Smedt
,
G. Leclercq
,
B. Verhasselt
,
B. Vandekerckhove
Blood
1996
Corpus ID: 13728017
Highly purified human CD34+ fetal liver stem cells differentiate to mature T cells when seeded in vitro into isolated fetal…
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Highly Cited
1994
Highly Cited
1994
Bcl-2 is upregulated at the CD4+ CD8+ stage during positive selection and promotes thymocyte differentiation at several control points.
G. Linette
,
M. Grusby
,
S. Hedrick
,
T. Hansen
,
L. Glimcher
,
S. Korsmeyer
Immunity
1994
Corpus ID: 36874364
Highly Cited
1994
Highly Cited
1994
An activated lck transgene promotes thymocyte development in RAG-1 mutant mice.
P. Mombaerts
,
P. Mombaerts
,
+4 authors
S. Tonegawa
Immunity
1994
Corpus ID: 37479319
Highly Cited
1993
Highly Cited
1993
Selective thymocyte depletion in neonatal HIV-1 thymic infection
M. Rosenzweig
,
D. Clark
,
G. Gaulton
AIDS (London)
1993
Corpus ID: 27695136
Objective:To determine the impact of HIV-1 infection on thymocyte development, and the role of thymic infection on the…
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Highly Cited
1992
Highly Cited
1992
Expression of cytokines and their receptors by human thymocytes and thymic stromal cells.
S. Wolf
,
A. Cohen
Immunology
1992
Corpus ID: 23525884
The repertoire of cytokine and cytokine receptor mRNA expressed by unstimulated human thymocytes and thymic stromal cells was…
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Highly Cited
1990
Highly Cited
1990
Soluble CD23 (Fc epsilon RII) and interleukin 1 synergistically induce early human thymocyte maturation
M. Djavad Mossalayi
,
J. Lecron
,
+6 authors
Patrice Debré
Journal of Experimental Medicine
1990
Corpus ID: 10747596
The ability of human thymus-derived CD7+CD2-CD3- cells to acquire mature T cell antigens was assessed. Purified CD7+ thymocytes…
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Highly Cited
1981
Highly Cited
1981
Delineation of human thymocyte differentiation pathways utilizing double-staining techniques with monoclonal antibodies.
N. Tidman
,
G. Janossy
,
M. Bodger
,
S. Granger
,
P. Kung
,
G. Goldstein
Clinical and Experimental Immunology
1981
Corpus ID: 29046026
Three new techniques have been introduced for the phenotypic analysis of human thymocytes and T cells. Monoclonal antibodies of…
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