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Interleukin 17–producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages
Findings provide a basis for understanding how inhibition of IFN-γ signaling enhances development of pathogenic TH-17 effector cells that can exacerbate autoimmunity. Expand
Functional diversity of helper T lymphocytes
The existence of subsets of CD4+ helper T lymphocytes that differ in their cytokine secretion patterns and effector functions provides a framework for understanding the heterogeneity of normal andExpand
Batf3 Deficiency Reveals a Critical Role for CD8α+ Dendritic Cells in Cytotoxic T Cell Immunity
An important role is suggested for CD8α+ dendritic cells and cross-presentation in responses to viruses and in tumor rejection in Batf3–/– mice. Expand
Development of TH1 CD4+ T cells through IL-12 produced by Listeria-induced macrophages.
This regulatory pathway may have evolved to enable innate immune cells, through interactions with microbial pathogens, to direct development of specific immunity toward the appropriate TH1 phenotype. Expand
BTLA is a lymphocyte inhibitory receptor with similarities to CTLA-4 and PD-1
BTLA is a third inhibitory receptor on T lymphocytes with similarities to cytotoxic T lymphocyte–associated antigen 4 (CTLA-4) and programmed death 1 (PD-1), and BTLA-deficient mice have increased specific antibody responses and enhanced sensitivity to experimental autoimmune encephalomyelitis. Expand
Peripheral CD103+ dendritic cells form a unified subset developmentally related to CD8α+ conventional dendritic cells
Evidence is provided for a developmental relationship between lymphoid organ–resident CD8α+ cDCs and nonlymphoid CD103+ DCs and their shared developmental dependence on the transcription factor Irf8. Expand
T-bet is a STAT1-induced regulator of IL-12R expression in naïve CD4+ T cells
T-bet is induced by IFN-γ and STAT1 signaling during T cell activation and mediates STAT1-dependent processes of TH1 development, including the induction of IL-12Rβ2. Expand
A Validated Regulatory Network for Th17 Cell Specification
It is found that cooperatively bound BATF and IRF4 contribute to initial chromatin accessibility and, with STAT3, initiate a transcriptional program that is then globally tuned by the lineage-specifying TF RORγt, which plays a focal deterministic role at key loci. Expand
Dendritic cell regulation of TH1-TH2 development
Understanding the control exerted by cytokines on T helper cell subsets 1 and 2 (TH1-TH2) development has progressed to a fairly satisfying knowledge of intracellular signals and transcriptionExpand
Th17: an effector CD4 T cell lineage with regulatory T cell ties.
Th17 lineage development is reviewed, emphasizing similarities and differences with established effector and regulatory T cell developmental programs that have important implications for immune regulation, immune pathogenesis, and host defense. Expand