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Stat6 is required for mediating responses to IL-4 and for development of Th2 cells.
Interleukin-4 (IL-4) stimulation of cells leads to the activation of multiple signaling pathways, one of which involves Stat6. We have generated Stat6-deficient mice by gene targeting in embryonicExpand
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Plasma cell differentiation requires the transcription factor XBP-1
Considerable progress has been made in identifying the transcription factors involved in the early specification of the B-lymphocyte lineage. However, little is known about factors that control theExpand
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Impaired IL-12 responses and enhanced development of Th2 cells in Stat4-deficient mice
INTERACTIONS between cytokine and receptor lead to the activation of multiple signalling molecules, including the family of signal transducer and activator of transcription (STAT) proteins1,2. Stat4Expand
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Depletion of CD4+ T cells in major histocompatibility complex class II-deficient mice
The maturation of T cells in the thymus is dependent on the expression of major histocompatibility complex (MHC) molecules. By disruption of the MHC class II Ab beta gene in embryonic stem cells,Expand
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Hyperproliferation and dysregulation of IL-4 expression in NF-ATp-deficient mice.
NF-ATp is a member of a family of genes that encodes the cytoplasmic component of the nuclear factor of activated T cells (NF-AT). In this study, we show that mice with a null mutation in the NF-ATpExpand
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The transcription factor NF-ATc is essential for cardiac valve formation
Nuclear factor of activated T cells (NF-AT) is the name of a family of four related transcription factors that may be needed for cytokine gene expression in activated lymphocytes. Here we report thatExpand
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Signal Transducer and Activator of Transcription Factor 6 (Stat6)-deficient Mice Are Protected from Antigen-induced Airway Hyperresponsiveness and Mucus Production
The pleiotropic cytokine interleukin 4 (IL-4) has been shown to regulate many processes thought to be important in the allergic diathesis. To determine the mechanism(s) by which IL-4 mediatesExpand
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Tissue-specific segregation of CD1d-dependent and CD1d-independent NK T cells.
NKT cells, defined as T cells expressing the NK cell marker NK1.1, are involved in tumor rejection and regulation of autoimmunity via the production of cytokines. We show in this study that two typesExpand
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Development and characterization of IL-21–producing CD4+ T cells
It has recently been shown that interleukin (IL)-21 is produced by Th17 cells, functions as an autocrine growth factor for Th17 cells, and plays critical roles in autoimmune diseases. In this study,Expand
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The IL-21 receptor augments Th2 effector function and alternative macrophage activation.
The IL-21 receptor (IL-21R) shows significant homology with the IL-4R, and CD4+ Th2 cells are an important source of IL-21. Here we examined whether the IL-21R regulates the development of Th2Expand
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