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CCL17 gene

Known as: THYMUS AND ACTIVATION-REGULATED CHEMOKINE, ABCD-2, CHEMOKINE, CC MOTIF, LIGAND 17 
This gene is involved in several processes such as T cell development in the thymus and mature T cell regulation.
National Institutes of Health

Related topics

Related topics

11 relations
CCL17 protein, humanCCL17 wt AlleleChemotaxisCytokine Receptor Binding
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Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2012
2012
Development of operational models of receptor activation including constitutive receptor activity and their use to determine the efficacy of the chemokine CCL17 at the CC chemokine receptor CCR4
BACKGROUND AND PURPOSE The operational model provides a key conceptual framework for the analysis of pharmacological data… Expand
Highly Cited
2009
Highly Cited
2009
The adenylyl cyclase-cAMP system suppresses TARC/CCL17 and MDC/CCL22 production through p38 MAPK and NF-kappaB in HaCaT keratinocytes.
Patients with atopic dermatitis (AD) have significantly reduced plasma cAMP levels, and the cAMP level is correlated with the… Expand
Highly Cited
2006
Highly Cited
2006
Interleukin-17 is a negative regulator of established allergic asthma
T helper (Th)17 cells producing interleukin (IL)-17 play a role in autoimmune and allergic inflammation. Here, we show that IL-23… Expand
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2004
2004
Thymus‐ and activation‐regulated chemokine (TARC/CCL17) induces a Th2‐dominated inflammatory reaction on intradermal injection in mice
Abstract:  TARC/CCL17 (thymus‐ and activation‐regulated chemokine) is a CC chemokine, which binds to the CC chemokine receptor‐4… Expand
Highly Cited
2002
Highly Cited
2002
In vitro assessment of chemokine receptor‐ligand interactions mediating mouse eosinophil migration
  • Michael T. Borchers, T. Ansay, +5 authors James J. Lee
  • Journal of leukocyte biology
  • 2002
    • Corpus ID: 10621022
Eosinophil migration from circulation is controlled, in part, by chemokines through a family of G‐protein‐coupled chemokine… Expand
Highly Cited
2001
Highly Cited
2001
Intervention of Thymus and Activation-Regulated Chemokine Attenuates the Development of Allergic Airway Inflammation and Hyperresponsiveness in Mice1
Thymus- and activation-regulated chemokine (TARC; CCL17) is a lymphocyte-directed CC chemokine that specifically chemoattracts CC… Expand
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Highly Cited
2001
Highly Cited
2001
Regulated production of the T helper 2-type T-cell chemoattractant TARC by human bronchial epithelial cells in vitro and in human lung xenografts.
The chemokine TARC is a ligand for the chemokine receptor CCR4 expressed on T helper (Th)2-type CD4 T cells. Allergic airway… Expand
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Highly Cited
2000
Highly Cited
2000
A Th2 chemokine, TARC, produced by keratinocytes may recruit CLA+CCR4+ lymphocytes into lesional atopic dermatitis skin.
Atopic dermatitis is an inflammatory skin disease in which the inflammation is characterized by the influx of lymphocytes into… Expand
1999
1999
Three chemokines with potential functions in T lymphocyte‐independent and ‐dependent B lymphocyte stimulation
Three clustered mouse chemokine genes, ABCD‐1, ‐2 and ‐3, are all expressed highly in dendritic cells and, at various levels, in… Expand
Highly Cited
1996
Highly Cited
1996
Molecular Cloning of a Novel T Cell-directed CC Chemokine Expressed in Thymus by Signal Sequence Trap Using Epstein-Barr Virus Vector*
Precursors of most secreted and cell surface molecules carry signal sequences at their amino termini. Here we describe an… Expand
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