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Characterization of SIS3, a Novel Specific Inhibitor of Smad3, and Its Effect on Transforming Growth Factor-β1-Induced Extracellular Matrix Expression
SIS3 completely diminished the constitutive phosphorylation of Smad3 as well as the up-regulated type I collagen expression in scleroderma fibroblasts, suggesting that SIS3 is a useful tool to evaluate the TGF-β-regulated cellular mechanisms via selective inhibition ofSmad3.
Thymus and activation-regulated chemokine in atopic dermatitis: Serum thymus and activation-regulated chemokine level is closely related with disease activity.
Serum TARC levels are associated with disease activity of AD, and TARC may play an important role in the pathogenesis of AD.
Regulatory B Cells (B10 Cells) Have a Suppressive Role in Murine Lupus: CD19 and B10 Cell Deficiency Exacerbates Systemic Autoimmunity
Both disease-promoting and protective roles for B cells in lupus pathogenesis are demonstrated, with an important protective role for regulatory B10 cells in this systemic autoimmune disease.
Overproduction of Th2-specific chemokines in NC/Nga mice exhibiting atopic dermatitis-like lesions.
Observations indicate that TARC and MDC actively participate in the pathogenesis of AD-like lesions in NC/Nga mice and that these Th2 chemokines could be novel targets for intervention therapy of AD in humans.
Interleukin-12 p40 gene (IL12B) 3'-untranslated region polymorphism is associated with susceptibility to atopic dermatitis and psoriasis vulgaris.
The genotype and allele frequencies of the IL12B SNP suggest that this SNP is associated with susceptibility to AD and PsV, presumably by affecting the Th1/Th2 balance.
Thymus and activation-regulated chemokine (TARC/CCL17) in mycosis fungoides: serum TARC levels reflect the disease activity of mycosis fungoides.
Serum TARC levels are useful for assessing the disease activity of patients with MF and that TARC and CCR4 may be involved in the pathogenesis of MF are strongly indicated.
Tenascin-C upregulation by transforming growth factor-β in human dermal fibroblasts involves Smad3, Sp1, and Ets1
Findings demonstrate the existence of a novel, functional binding element in the proximal region of the TN-C promoter mediating responsiveness to TGF-β involving Smad3/4, Sp1, Ets1, and CBP/p300.
Origin and Function of Epidermal Langerhans Cells
In 1868, the medical student Paul Langerhans discovered a population of dendritic cells in the suprabasal regions of the epidermis by impregnating human skin with gold salts (Langerhans 1868). These
CD19 regulates innate immunity by the toll-like receptor RP105 signaling in B lymphocytes.
It is demonstrated that CD19 plays a major role in regulating signal transduction through RP105, a major gram-negative bacterial component that stimulates innate immune response and also induces B-lymphocyte activation.
The Repeat Domain of the Melanosomal Matrix Protein PMEL17/GP100 Is Required for the Formation of Organellar Fibers*
It is concluded that the RPT domain is essential for its function in generating the fibrillar matrix of melanosomes and that the luminal domain is necessary for its correct processing and trafficking to those organelles.