IL-10 augments the IFN-gamma and TNF-alpha induced TARC production in HaCaT cells: a possible mechanism in the inflammatory reaction of atopic dermatitis.

@article{Vestergaard2001IL10AT,
  title={IL-10 augments the IFN-gamma and TNF-alpha induced TARC production in HaCaT cells: a possible mechanism in the inflammatory reaction of atopic dermatitis.},
  author={Christian L. Vestergaard and N Kirstejn and Borb{\`a}la Petrics Gesser and Janne Touborg Mortensen and Kouji Matsushima and Christian Gr\onh\oj Larsen},
  journal={Journal of dermatological science},
  year={2001},
  volume={26 1},
  pages={46-54}
}
The CC-chemokine TARC is known to be a ligand for the CCR4 receptor which in turn is known to be expressed selectively on the Th(2)-subset of lymphocytes. Atopic dermatitis is generally believed to be a Th(2)-type disease, and TARC has been shown to be expressed in the skin lesions of a murine model of AD. IL-10 is an interleukine generally known for its ability to inhibit cytokine production, however it has been found to be highly expressed in the skin from AD patients. We show in this report… CONTINUE READING