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Loss of CD45R and gain of UCHL1 reactivity is a feature of primed T cells.
A group of mAb recognizing the 200- and/or 220-kDa determinants (CD45R) of the leukocyte common Ag such as 2H4, WR16, MD4.3, and SN130 cross-block each other showing that they recognize a closelyExpand
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Acid Esterase in Human Lymphoid Cells and Leukaemic Blasts: a Marker for T Lymphocytes
A non‐specific acid alpha‐naphthyl‐acetate esterase activity was investigated in human lymphoid cell populations from tonsils, blood, thymus and in different leukaemias. Four patterns have emerged.Expand
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Laboratory control values for CD4 and CD8 T lymphocytes. Implications for HIV‐1 diagnosis
With the advent of standard flow cytometric methods using two‐colour fluorescence on samples of whole blood, it is possible to establish the ranges of CD3. CD 4 and CDS T lymphocyte subsets in theExpand
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Intracellular cytokine profile of cord and adult blood lymphocytes.
Umbilical cord blood (CB) transplantation is thought to be associated with a reduced risk of severe graft-versus-host-disease (GVHD) compared with bone marrow transplantation (BMT). The cytokineExpand
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The significance of low bcl-2 expression by CD45RO T cells in normal individuals and patients with acute viral infections. The role of apoptosis in T cell memory
The bcl-2 gene product has been shown to prevent apoptotic cell death. We have now investigated the bcl-2 protein expression by resting and activated mature T cell populations. Freshly isolatedExpand
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Infrequent normal B lymphocytes express features of B-chronic lymphocytic leukemia
An infrequent (2-3%) B lymphocyte subpopulation was found in the normal human tonsil and lymph nodes that shows the phenotypic characteristics of B-chronic lymphocytic leukemia (B-CLL) (rosetteExpand
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Lymphocyte activation in HIV‐1 infection. II. Functional defects of CD28− T cells
Objectives and design:The expression of the accessory molecule CD28 was compared in various populations of T and natural killer (NK) cells from HIV-1-negative and HIV-1-positive individuals andExpand
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Human B cell development. I. Phenotypic differences of B lymphocytes in the bone marrow and peripheral lymphoid tissue.
The phenotype of B lineage cells (TdT+, pre-B, IgM+, IgD-, and IgM+,IgD+) in infant and adult human bone marrow was compared with that of B cells seen in peripheral tissues such as tonsil and blood.Expand
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Affordable CD4+ T‐cell counts on ‘single‐platform’ flow cytometers I. Primary CD4 gating
Here, we demonstrate the flow cytometric concept of ‘primary CD4 gating’ utilizing three different CD4 monoclonal antibodies (mAbs) conjugated with five different fluorochromes. CD4+ lymphocytes wereExpand
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Terminal transferase-positive human bone marrow cells exhibit the antigenic phenotype of common acute lymphoblastic leukemia.
Combined immunologic assays for TdT enzyme and membrane markers show that TdT+ cells in nonleukemic human bone marrow carry ALL-associated and Ia-like antigens but no thymocyte markers or surface Ig.Expand
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