• Publications
  • Influence
CD27 Defines Phenotypically and Functionally Different Human NK Cell Subsets
TLDR
The absence of the TNF-receptor family member CD27 marks the stable acquisition of cytolytic effector functions by both CD4+ and CD8+ T cells, and the definition of cytotoxic effector cells within the known mature NK cell subsets in humans is defined.
Interactions of Ly49 Family Receptors with MHC Class I Ligands in trans and cis1
TLDR
It is shown that the accessibility of most, but not all, MHC-I-binding Ly49 receptors is modulated by the expression of M HC-I in cis, and the structure of Ly49I was partly masked on transfected tumor cells, suggesting that the structure is compatible in principal with cis binding of MHC -I.
Differential effects of interleukin-15 and interleukin-2 on differentiation of bipotential T/natural killer progenitor cells
TLDR
Direct evidence is provided that IL-15 and IL-2 differentially affect the differentiation of bipotential T/NK progenitors.
A Role for cis Interaction between the Inhibitory Ly49A receptor and MHC class I for natural killer cell education.
TLDR
A Ly 49A variant is described, which can engage MHC-I expressed on other cells but not in cis, and this was found to relieve NK cells from a suppressive effect of unengaged Ly49A.
Generation of T Cells from Human Embryonic Stem Cell-Derived Hematopoietic Zones1
TLDR
It is shown that T cells can be generated in vitro from hESC-derived hematopoietic precursor cells present in hematopolietic zones (HZs), further substantiating the notion that hESc-derived CD34highCD43low cells are formed in HZs and are the only population containing multipotent hematopsian precursor cells.
Characterization of distinct stages during the differentiation of human CD69+CD3+ thymocytes and identification of thymic emigrants.
TLDR
Thymocyte differentiation appears to continue in an ordered pattern, and cells that eventually leave the thymus are CD69-CD1-CD45RA+ or CD45RA-/dull cells, because phenotype IV and phenotype V thymocytes rapidly lose CD69 expression in cell culture, these thymocyte cells are probably the cells that are exported from theThymus.
Activated CD4+CD25+ regulatory T cells inhibit osteoclastogenesis and collagen-induced arthritis
TLDR
Activated CD4+CD25+ Treg cells improve clinical symptoms of CIA, regulate cytokine production and inhibit osteoclastogenesis in vitro and in vivo.
KLRG1 binds cadherins and preferentially associates with SHIP-1.
TLDR
KLRG1 may differentially regulate NK cell and T cell functions through the association with different ligands as well as the recruitment of distinct phosphatases, and it is demonstrated that K LRG1 engagement can inhibit sub-optimal TCR signaling.
Matrix Metalloprotease 8-Dependent Extracellular Matrix Cleavage at the Blood–CSF Barrier Contributes to Lethality during Systemic Inflammatory Diseases
TLDR
It is reported that matrix metalloprotease-8 (MMP8) depletion or inhibition protects mice from death and hypothermia in sepsis and renal ischemia/reperfusion and proposes that the mechanism of action of MMP8 involves disruption of the BCSFB integrity.
Defective CD4+CD25+ regulatory T cell functioning in collagen-induced arthritis: an important factor in pathogenesis, counter-regulated by endogenous IFN-γ
TLDR
It is demonstrated that the decrease in Treg cell activity in CIA is counter-regulated by endogenous IFN-γ, which accounts for more suppressive activity in wild-type mice, concerns both Treg cells and accessory cells.
...
1
2
3
4
5
...