Endoplasmic Reticulum Stress Links Obesity, Insulin Action, and Type 2 Diabetes
- Umut Özcan, Qiong Cao, G. Hotamisligil
- Biology, MedicineScience
- 15 October 2004
It is shown that obesity causes endoplasmic reticulum (ER) stress, which leads to suppression of insulin receptor signaling through hyperactivation of c-Jun N-terminal kinase (JNK) and subsequent serine phosphorylation of insulin receptors substrate–1 (IRS-1).
XBP-1 Regulates a Subset of Endoplasmic Reticulum Resident Chaperone Genes in the Unfolded Protein Response
- Ann-Hwee Lee, N. Iwakoshi, L. Glimcher
- BiologyMolecular and Cellular Biology
- 1 November 2003
It is suggested that the IRE1/XBP-1 pathway is required for efficient protein folding, maturation, and degradation in the ER and imply the existence of subsets of UPR target genes as defined by their dependence on XBP- 1.
A Novel Transcription Factor, T-bet, Directs Th1 Lineage Commitment
- S. Szabo, Sean T. Kim, G. Costa, Xiankui Zhang, C. Fathman, L. Glimcher
- BiologyCell
- 17 March 2000
XBP1 Links ER Stress to Intestinal Inflammation and Confers Genetic Risk for Human Inflammatory Bowel Disease
- A. Kaser, Ann-Hwee Lee, R. Blumberg
- Medicine, BiologyCell
- 5 September 2008
TLR activation of the transcription factor XBP1 regulates innate immune responses in macrophages
- F. Martinon, X. Chen, Ann-Hwee Lee, L. Glimcher
- BiologyNature Immunology
- 1 May 2010
This work reports that TLR4 and TLR2 specifically activated the endoplasmic reticulum (ER) stress sensor kinase IRE1α and its downstream target, the transcription factor XBP1, identifying an unsuspected critical function for XBP 1 in mammalian host defenses.
Regulation of Hepatic Lipogenesis by the Transcription Factor XBP1
- Ann-Hwee Lee, E. Scapa, D. Cohen, L. Glimcher
- Biology, MedicineScience
- 13 June 2008
It is found that the transcription factor XBP1, a key regulator of the unfolded protein response, is required for the unrelated function of normal fatty acid synthesis in the liver.
T-bet regulates the terminal maturation and homeostasis of NK and Valpha14i NKT cells.
- M. Townsend, A. Weinmann, L. Glimcher
- BiologyImmunity
- 1 April 2004
XBP1, downstream of Blimp-1, expands the secretory apparatus and other organelles, and increases protein synthesis in plasma cell differentiation.
- A. Shaffer, Miriam Shapiro-Shelef, L. Staudt
- BiologyImmunity
- 1 July 2004
Molecular mechanisms regulating Th1 immune responses.
- S. Szabo, B. Sullivan, S. Peng, L. Glimcher
- Biology, MedicineAnnual Review of Immunology
- 28 November 2003
The mechanisms that control lineage commitment to the Th1 phenotype are discussed, and the basic pathways leading to Th1 differentiation can now be understood in in vitro and a number of infection and disease models.
Plasma cell differentiation and the unfolded protein response intersect at the transcription factor XBP-1
- N. Iwakoshi, Ann-Hwee Lee, P. Vallabhajosyula, K. Otipoby, K. Rajewsky, L. Glimcher
- BiologyNature Immunology
- 3 March 2003
UPR-induced splicing of XBP-1 by the transmembrane endonuclease IRE1 is required to restore production of immunoglobulin in XBP -1−/− mouse B cells, providing an integral link between X BP-1, the UPR and plasma cell differentiation.
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