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House dust mite allergen induces asthma via Toll-like receptor 4 triggering of airway structural cells
Barrier epithelial cells and airway dendritic cells (DCs) make up the first line of defense against inhaled substances such as house dust mite (HDM) allergen and endotoxin (lipopolysaccharide, LPS).Expand
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Localization, quantitation, and in situ detection of specific peptide-MHC class I complexes using a monoclonal antibody.
CD8+ T lymphocytes recognize antigens as short peptides bound to MHC class I molecules. Available methods cannot determine the number and distribution of these ligands on individual cells or detectExpand
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In Vivo Microbial Stimulation Induces Rapid CD40 Ligand–independent Production of Interleukin 12 by Dendritic Cells and their Redistribution to T Cell Areas
The early induction of interleukin (IL)-12 is a critical event in determining the development of both innate resistance and adaptive immunity to many intracellular pathogens. Previous in vitroExpand
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In Vivo Imaging Reveals an Essential Role for Neutrophils in Leishmaniasis Transmitted by Sand Flies
Infection with the obligate intracellular protozoan Leishmania is thought to be initiated by direct parasitization of macrophages, but the early events following transmission to the skin by vectorExpand
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T-cell development and the CD4–CD8 lineage decision
  • R. Germain
  • Biology, Medicine
  • Nature Reviews Immunology
  • 1 May 2002
Cell-fate decisions are controlled typically by conserved receptors that interact with co-evolved ligands. Therefore, the lineage-specific differentiation of immature CD4+CD8+ T cells into CD4+ orExpand
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TCR ligand discrimination is enforced by competing ERK positive and SHP-1 negative feedback pathways
Functional discrimination between structurally similar self and foreign antigens is a main attribute of adaptive immunity. Here we describe two feedback mechanisms in T lymphocytes that togetherExpand
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Defining CD8+ T cells that provide the proliferative burst after PD-1 therapy
Chronic viral infections are characterized by a state of CD8+ T-cell dysfunction that is associated with expression of the programmed cell death 1 (PD-1) inhibitory receptor. A better understandingExpand
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SAP-controlled T-B cell interactions underlie germinal centre formation
Generation of long-term antibody-mediated immunity depends on the germinal centre reaction, which requires cooperation between antigen-specific T and B lymphocytes. In human X-linkedExpand
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Dynamic imaging of dendritic cell extension into the small bowel lumen in response to epithelial cell TLR engagement
Cells lining the gastrointestinal tract serve as both a barrier to and a pathway for infectious agent entry. Dendritic cells (DCs) present in the lamina propria under the columnar villus epitheliumExpand
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Stromal cell contributions to the homeostasis and functionality of the immune system
A defining characteristic of the immune system is the constant movement of many of its constituent cells through the secondary lymphoid tissues, mainly the spleen and lymph nodes, where crucialExpand
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