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Inactivation of YAP oncoprotein by the Hippo pathway is involved in cell contact inhibition and tissue growth control.
It is demonstrated that in mammalian cells, the transcription coactivator YAP (Yes-associated protein), is inhibited by cell density via the Hippo pathway, and YAP overexpression regulates gene expression in a manner opposite to cell density, and is able to overcome cell contact inhibition.
TEAD mediates YAP-dependent gene induction and growth control.
TEAD is revealed as a new component in the Hippo pathway playing essential roles in mediating biological functions of YAP, and is required for YAP-induced cell growth, oncogenic transformation, and epithelial-mesenchymal transition.
The Mutational Landscape of Lethal Castrate Resistant Prostate Cancer
The mutational landscape of a heavily treated metastatic cancer is described, novel mechanisms of AR signalling deregulated in prostate cancer are identified, and candidates for future study are prioritize.
Development of human protein reference database as an initial platform for approaching systems biology in humans.
This unified bioinformatics platform will be useful in cataloging and mining the large number of proteomic interactions and alterations that will be discovered in the postgenomic era.
The polycomb group protein EZH2 is involved in progression of prostate cancer
Dysregulated expression of EZH2 may be involved in the progression of prostate cancer, as well as being a marker that distinguishes indolent prostate cancer from those at risk of lethal progression.
The Receptor for the Cytotoxic Ligand TRAIL
The DR4-TRAIL axis defines another receptor-ligand pair involved in regulating cell suicide and tissue homeostasis.