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Recurrent fusion of TMPRSS2 and ETS transcription factor genes in prostate cancer.
Recurrent chromosomal rearrangements have not been well characterized in common carcinomas. We used a bioinformatics approach to discover candidate oncogenic chromosomal aberrations on the basis of… Expand
Inactivation of YAP oncoprotein by the Hippo pathway is involved in cell contact inhibition and tissue growth control.
The Hippo pathway plays a key role in organ size control by regulating cell proliferation and apoptosis in Drosophila. Although recent genetic studies have shown that the Hippo pathway is regulated… Expand
TEAD mediates YAP-dependent gene induction and growth control.
The YAP transcription coactivator has been implicated as an oncogene and is amplified in human cancers. Recent studies have established that YAP is phosphorylated and inhibited by the Hippo tumor… Expand
The Mutational Landscape of Lethal Castrate Resistant Prostate Cancer
Characterization of the prostate cancer transcriptome and genome has identified chromosomal rearrangements and copy number gains and losses, including ETS gene family fusions, PTEN loss and androgen… Expand
FADD, a novel death domain-containing protein, interacts with the death domain of fas and initiates apoptosis
Using the cytoplasmic domain of Fas in the yeast two-hybrid system, we have identified a novel interacting protein, FADD, which binds Fas and Fas-FD5, a mutant of Fas possessing enhanced killing… Expand
Development of human protein reference database as an initial platform for approaching systems biology in humans.
- S. Peri, J. D. Navarro, +49 authors A. Pandey
- Computer Science, Medicine
- Genome research
- 1 October 2003
Human Protein Reference Database (HPRD) is an object database that integrates a wealth of information relevant to the function of human proteins in health and disease. Expand
Integrative Clinical Genomics of Advanced Prostate Cancer
Toward development of a precision medicine framework for metastatic, castration-resistant prostate cancer (mCRPC), we established a multi-institutional clinical sequencing infrastructure to conduct… Expand
The polycomb group protein EZH2 is involved in progression of prostate cancer
Prostate cancer is a leading cause of cancer-related death in males and is second only to lung cancer. Although effective surgical and radiation treatments exist for clinically localized prostate… Expand
The Receptor for the Cytotoxic Ligand TRAIL
TRAIL (also known as Apo-2L) is a member of the tumor necrosis factor (TNF) ligand family that rapidly induces apoptosis in a variety of transformed cell lines. The human receptor for TRAIL was found… Expand
ONCOMINE: a cancer microarray database and integrated data-mining platform.
DNA microarray technology has led to an explosion of oncogenomic analyses, generating a wealth of data and uncovering the complex gene expression patterns of cancer. Unfortunately, due to the lack of… Expand