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Projection of an Immunological Self Shadow Within the Thymus by the Aire Protein
Humans expressing a defective form of the transcription factor AIRE (autoimmune regulator) develop multiorgan autoimmune disease. We used aire- deficient mice to test the hypothesis that this… Expand
Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters
Obesity is accompanied by chronic, low-grade inflammation of adipose tissue, which promotes insulin resistance and type-2 diabetes. These findings raise the question of how fat inflammation can… Expand
FOXP3 Controls Regulatory T Cell Function through Cooperation with NFAT
Antigen stimulation of immune cells activates the transcription factor NFAT, a key regulator of T cell activation and anergy. NFAT forms cooperative complexes with the AP-1 family of transcription… Expand
From systemic T cell self-reactivity to organ-specific autoimmune disease via immunoglobulins.
Rheumatoid arthritis is a common and debilitating autoimmune disease whose cause and mechanism remain a mystery. We recently described a T cell receptor transgenic mouse model that spontaneously… Expand
The Immunological Genome Project: networks of gene expression in immune cells
The Immunological Genome Project combines immunology and computational biology laboratories in an effort to establish a complete 'road map' of gene-expression and regulatory networks in all immune… Expand
PPARγ is a major driver of the accumulation and phenotype of adipose-tissue Treg cells
Obesity and type-2 diabetes have increased markedly over the past few decades, in parallel. One of the major links between these two disorders is chronic, low-grade inflammation. Prolonged nutrient… Expand
The cellular mechanism of Aire control of T cell tolerance.
- M. Anderson, Emily S. Venanzi, Z. Chen, S. Berzins, C. Benoist, D. Mathis
- Biology, Medicine
- 1 August 2005
Aire promotes the tolerization of thymocytes by inducing the expression of a battery of peripheral-tissue antigens in thymic medullary epithelial cells. We demonstrate that the cellular mechanism by… Expand
A Special Population of Regulatory T Cells Potentiates Muscle Repair
Long recognized to be potent suppressors of immune responses, Foxp3(+)CD4(+) regulatory T (Treg) cells are being rediscovered as regulators of nonimmunological processes. We describe a phenotypically… Expand
Arthritis provoked by linked T and B cell recognition of a glycolytic enzyme.
The hallmark of rheumatoid arthritis (RA) is specific destruction of the synovial joints. In a mouse line that spontaneously develops a disorder with many of the features of human RA, disease is… Expand
The AKT–mTOR axis regulates de novo differentiation of CD4+Foxp3+ cells
- Sokol Haxhinasto, D. Mathis, C. Benoist
- Medicine, Biology
- The Journal of experimental medicine
- 17 March 2008
CD4+Foxp3+ regulatory T (T reg) cells play an essential role in maintaining immunological tolerance via their suppressive function on conventional CD4+ T (Tconv) cells. Repertoire studies suggest… Expand