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Projection of an Immunological Self Shadow Within the Thymus by the Aire Protein
Aire-deficient thymic medullary epithelial cells showed a specific reduction in ectopic transcription of genes encoding peripheral antigens, highlighting the importance of thymically imposed “central” tolerance in controlling autoimmunity.
Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters
Observations suggest that harnessing the anti-inflammatory properties of Treg cells to inhibit elements of the metabolic syndrome may have therapeutic potential.
The Immunological Genome Project: networks of gene expression in immune cells
The Immunological Genome Project combines immunology and computational biology laboratories in an effort to establish a complete 'road map' of gene-expression and regulatory networks in all immune
PPARγ is a major driver of the accumulation and phenotype of adipose-tissue Treg cells
Peroxisome proliferator-activated receptor (PPAR)-γ, the ‘master regulator’ of adipocyte differentiation, is identified as a crucial molecular orchestrator of VAT Treg cell accumulation, phenotype and function, and a previously unknown cellular mechanism for this important class of thiazolidinedione drugs is suggested.