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NOS3 protein, human

Known as: NOS3, ECNOS protein, human, EC-NOS 
Nitric oxide synthase, endothelial (1203 aa, ~133 kDa) is encoded by the human NOS3 gene. This protein plays a role in the modulation of vascular… 
National Institutes of Health

Related topics

Related topics

17 relations
Angiogenesis PathwayAngiogenic ProcessCorticosteroid Cardioprotection PathwayEnosis

Broader (1)

Nitric Oxide Synthase Type III

Papers overview

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Highly Cited
2011
Highly Cited
2011
Epigenetic Gene Promoter Methylation at Birth Is Associated With Child’s Later Adiposity
OBJECTIVE Fixed genomic variation explains only a small proportion of the risk of adiposity. In animal models, maternal diet… 
Highly Cited
2011
Highly Cited
2011
Mechanisms underlying adverse effects of HDL on eNOS-activating pathways in patients with coronary artery disease.
Therapies that raise levels of HDL, which is thought to exert atheroprotective effects via effects on endothelium, are being… 
Highly Cited
2009
Highly Cited
2009
Resveratrol induces mitochondrial biogenesis in endothelial cells
Pathways that regulate mitochondrial biogenesis are potential therapeutic targets for the amelioration of endothelial dysfunction… 
Highly Cited
2009
Highly Cited
2009
Activation of AMP-Activated Protein Kinase by Metformin Improves Left Ventricular Function and Survival in Heart Failure
Clinical studies have reported that the widely used antihyperglycemic drug metformin significantly reduces cardiac risk factors… 
Review
2006
Review
2006
Physiological role of ROCKs in the cardiovascular system.
Rho-associated kinases (ROCKs), the immediate downstream targets of RhoA, are ubiquitously expressed serine-threonine protein… 
Review
2003
Review
2003
New insights on oxidative stress and diabetic complications may lead to a "causal" antioxidant therapy.
Evidence implicates hyperglycemia-derived oxygen free radicals as mediators of diabetic complications. However, intervention… 
Highly Cited
2002
Highly Cited
2002
Rho-Kinase Mediates Hypoxia-Induced Downregulation of Endothelial Nitric Oxide Synthase
Background—Hypoxia-induced pulmonary hypertension is a major cause of morbidity and mortality. Hypoxia induces pulmonary… 
Highly Cited
2001
Highly Cited
2001
Plasma nitrite rather than nitrate reflects regional endothelial nitric oxide synthase activity but lacks intrinsic vasodilator action
The plasma level of NOx, i.e., the sum of NO2− and NO3−, is frequently used to assess NO bioavailability in vivo. However, little… 
Review
1997
Review
1997
Nitric oxide synthase in models of focal ischemia.
BACKGROUND AND PURPOSE Cessation of blood flow to the brain, for even a few minutes, sets in motion a potential reversible… 
Highly Cited
1994
Highly Cited
1994
Beneficial effects and improved survival in rodent models of septic shock with S-methylisothiourea sulfate, a potent and selective inhibitor of inducible nitric oxide synthase.
Enhanced formation of nitric oxide (NO) by both the constitutive and the inducible isoforms of NO synthase (NOS) has been… 
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