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BCL2 protein, human

Known as: B-Cell CLL/lymphoma 2, B-cell CLL-lymphoma 2 protein, human, B-cell leukemia/lymphoma 2 protein 
A protein that helps control whether a cell lives or dies by blocking a type of cell death called apoptosis. The gene for BCL2 is found on chromosome… 
National Institutes of Health

Related topics

Related topics

22 relations

Broader (4)

ApoptosisB-Cell Leukemia 2 Family ProteinsProto-Oncogene Proteins c-bcl-2Proto-Oncogenes
Apoptosis InhibitorB-Cell ActivationBCL2 geneBCL2 wt Allele

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2009
Highly Cited
2009
Different forms of cell death induced by putative BCL2 inhibitors
Several inhibitors of BCL2 proteins have been identified that induce apoptosis in a variety of tumor cells, indicating their… 
Highly Cited
2007
Highly Cited
2007
Overexpression of nucleolin in chronic lymphocytic leukemia cells induces stabilization of bcl2 mRNA.
B-cell chronic lymphocytic leukemia (CLL) is characterized by the accumulation of clonal B cells that are resistant to apoptosis… 
Highly Cited
1999
Highly Cited
1999
An elevated bax/bcl-2 ratio corresponds with the onset of prostate epithelial cell apoptosis
The prostate gland in adult male rats is highly dependent on androgenic steroids. Castration initiates the regression of this… 
Highly Cited
1995
Highly Cited
1995
Expression of bcl-2 protein predicts efficacy of adjuvant treatments in operable node-positive breast cancer.
The proto-oncogene bcl-2 encodes a protein that inhibits apoptosis, a common mechanism of cell death caused by hormone and… 
Highly Cited
1994
Highly Cited
1994
bcl-2 protein expression is widespread in the developing nervous system and retained in the adult PNS.
Cell death is a common feature of neural development in all vertebrates. The bcl-2 proto-oncogene has been shown to protect a… 
Highly Cited
1994
Highly Cited
1994
Interleukin-10 prevents spontaneous death of germinal center B cells by induction of the bcl-2 protein.
In this study, we show that IL-10 enhances in vitro the viability of purified splenic B cells. There was a two- to threefold… 
Highly Cited
1994
Highly Cited
1994
Subcellular localization of the bcl-2 protein in malignant and normal lymphoid cells.
The bcl-2 oncogene is expressed in lymphoid and myeloid cells as well as in neurons and several types of epithelial cells and… 
Highly Cited
1993
Highly Cited
1993
Expression of bcl-2 in fetal tissues suggests a role in morphogenesis.
We have studied the distribution of the bcl-2 protein in fetal tissues, in an effort to uncover patterns of expression that may… 
Highly Cited
1992
Highly Cited
1992
Ultrastructural localization of bcl-2 protein.
Previous cell subfractionation studies have indicated that bcl-2 is an inner mitochondrial membrane protein. We have sought to… 
Highly Cited
1991
Highly Cited
1991
Germinal center cells express bcl‐2 protein after activation by signals which prevent their entry into apoptosis
B cells undergo selection within germinal centers on the basis of their capacity to be activated by antigen held on follicular… 
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