Biologic and clinical significance of cryoglobulins. A report of 86 cases.
High-dose therapy and autologous blood stem-cell transplantation compared with conventional treatment in myeloma patients aged 55 to 65 years: long-term results of a randomized control trial from the…
This randomized trial confirmed a benefit ofHDT in terms of EFS and TwiSTT but did not provide evidence for superiority of HDT over CCT in OS of patients aged 55 to 65 years with symptomatic newly diagnosed MM.
Role of interleukin 10 in the B lymphocyte hyperactivity and autoantibody production of human systemic lupus erythematosus
The results indicate that the Ig production by SLE B lymphocytes is largely IL-10 dependent, and that the increased production ofIL-10 by Sle B lymphocyte and monocytes may represent a critical mechanism in the emergence of the autoimmune manifestations of the disease.
High-dose therapy and autologous peripheral blood stem cell transplantation in multiple myeloma: up-front or rescue treatment? Results of a multicenter sequential randomized clinical trial.
HDR with PBSC transplantation obtained a median OS exceeding 5 years in young patients with symptomatic MM, whether performed early, as first-line therapy, or late, as rescue treatment, suggesting early HDT may be preferred because it is associated with a shorter period of chemotherapy.
Late-onset combined immune deficiency: a subset of common variable immunodeficiency with severe T cell defect.
- M. Malphettes, L. Gérard, É. Oksenhendler
- Medicine, BiologyClinical Infectious Diseases
- 15 November 2009
Identification of systematic T cell phenotype should result in a more fitted diagnostic and therapeutic approach of infections and could provide insights for genetic diagnosis.
Clinico‐biological characteristics and treatment of type I monoclonal cryoglobulinaemia: a study of 64 cases
Type I cryoglobulinaemia has specific clinico‐biological characteristics compared to type II CG and there are differences in terms of related manifestations between type I IgG andtype I IgM CG.
The clinicopathological features of extensive small intestinal CD4 T cell infiltration
Extensive small intestinal CD4 T cell infiltration is a rare entity, distinct from coeliac disease and associated with prolonged survival in patients with chronic diarrhoea, mal absorption, and weight loss.
Prognostic value of vertebral lesions detected by magnetic resonance imaging in patients with stage I multiple myeloma
We assessed the role of spinal magnetic resonance imaging (MRI) and bone densitometry as prognostic factors in patients with asymptomatic stage I multiple myeloma (MM) and negative skeletal survey.…
Phase II trial of arsenic trioxide and alpha interferon in patients with relapsed/refractory adult T-cell leukemia/lymphoma.
Arsenic trioxide/IFN treatment is feasible and exhibits an anti-leukemia effect in very poor prognosis ATL patients despite a significant toxicity.
Lymphomas in patients with Sjogren's syndrome are marginal zone B-cell neoplasms, arise in diverse extranodal and nodal sites, and are not associated with viruses.
L lymphomas occurring in patients with an underlying SS are in most cases MZL, and are not associated with viruses known to be present in other types of lymphomas.