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Somatic CALR mutations in myeloproliferative neoplasms with nonmutated JAK2.
TLDR
Somatic mutations in the endoplasmic reticulum chaperone CALR were found in a majority of patients with myeloproliferative neoplasms with nonmutated JAK2, a finding consistent with its role as an initiating mutation in some patients. Expand
The CD4 (T4) antigen is an essential component of the receptor for the AIDS retrovirus
TLDR
It is concluded that the CD4 antigen is an essential and specific component of the receptor for the causative agent of AIDS. Expand
Loci on 7p12.2, 10q21.2 and 14q11.2 are associated with risk of childhood acute lymphoblastic leukemia
TLDR
Data show that common low-penetrance susceptibility alleles contribute to the risk of developing childhood ALL and provide new insight into disease causation of this specific hematological cancer. Expand
Expression of the CD34 gene in vascular endothelial cells.
TLDR
It is concluded that under these conditions, CD34 protein is downregulated or processed into another form that is unreactive with CD34 antibodies, and not to crossreactive epitopes. Expand
Acute lymphoblastic leukaemia
TLDR
Genome-wide profiling of germline and leukaemic cell DNA has identified novel submicroscopic structural genetic changes and sequence mutations that contribute to leukaemogenesis, define new disease subtypes, affect responsiveness to treatment, and might provide novel prognostic markers and therapeutic targets for personalised medicine. Expand
RAG-mediated recombination is the predominant driver of oncogenic rearrangement in ETV6-RUNX1 acute lymphoblastic leukemia
TLDR
A remarkably parsimonious mutational process transforms ETV6-RUNX1–positive lymphoblasts, targeting the promoters, enhancers and first exons of genes that normally regulate B cell differentiation. Expand
A one-step purification of membrane proteins using a high efficiency immunomatrix.
A method is described by which an immunoaffinity matrix was constructed by binding antibody directly or indirectly to protein A-Sepharose 4B followed by cross-linking of the complex with dimethylExpand
Methylenetetrahydrofolate reductase (MTHFR) polymorphisms and risk of molecularly defined subtypes of childhood acute leukemia
TLDR
Differences in allelic associations may point to discrete attributes of the two alleles in their ability to alter folate and one-carbon metabolite pools and impact after DNA synthesis and methylation pathways, but should be viewed cautiously pending larger follow-up studies. Expand
Mechanisms of clonal evolution in childhood acute lymphoblastic leukemia
TLDR
It is demonstrated that AID and RAG1-RAG2 drove leukemic clonal evolution with repeated exposure to inflammatory stimuli, paralleling chronic infections in childhood. Expand
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