Somatic CALR mutations in myeloproliferative neoplasms with nonmutated JAK2.
- J. Nangalia, C. Massie, A. Green
- Medicine, BiologyNew England Journal of Medicine
- 18 December 2013
Somatic mutations in the endoplasmic reticulum chaperone CALR were found in a majority of patients with myeloproliferative neoplasms with nonmutated JAK2, a finding consistent with its role as an initiating mutation in some patients.
The CD4 (T4) antigen is an essential component of the receptor for the AIDS retrovirus
- A. Dalgleish, P. Beverley, P. Clapham, D. Crawford, M. Greaves, R. Weiss
- Biology, MedicineNature
- 1984
It is concluded that the CD4 antigen is an essential and specific component of the receptor for the causative agent of AIDS.
Loci on 7p12.2, 10q21.2 and 14q11.2 are associated with risk of childhood acute lymphoblastic leukemia
- E. Papaemmanuil, F. Hosking, R. Houlston
- BiologyNature Genetics
- 16 August 2009
Data show that common low-penetrance susceptibility alleles contribute to the risk of developing childhood ALL and provide new insight into disease causation of this specific hematological cancer.
Expression of the CD34 gene in vascular endothelial cells.
- L. Fina, H. Molgaard, M. Greaves
- Biology, MedicineBlood
- 15 June 1990
It is concluded that under these conditions, CD34 protein is downregulated or processed into another form that is unreactive with CD34 antibodies, and not to crossreactive epitopes.
Acute lymphoblastic leukaemia
- H. Inaba, M. Greaves, C. Mullighan
- Medicine, BiologyThe Lancet
- 1 June 2013
RAG-mediated recombination is the predominant driver of oncogenic rearrangement in ETV6-RUNX1 acute lymphoblastic leukemia
- E. Papaemmanuil, I. Rapado, P. Campbell
- BiologyNature Genetics
- 15 November 2013
A remarkably parsimonious mutational process transforms ETV6-RUNX1–positive lymphoblasts, targeting the promoters, enhancers and first exons of genes that normally regulate B cell differentiation.
A one-step purification of membrane proteins using a high efficiency immunomatrix.
- C. Schneider, R. Newman, D. Sutherland, U. Asser, M. Greaves
- BiologyJournal of Biological Chemistry
- 25 September 1982
Speculations on the cause of childhood acute lymphoblastic leukemia.
- M. Greaves
- MedicineLeukemia
- 1988
Methylenetetrahydrofolate reductase (MTHFR) polymorphisms and risk of molecularly defined subtypes of childhood acute leukemia
- J. Wiemels, Rosalyn N. Smith, G. M. Taylor, O. Eden, F. Alexander, M. Greaves
- Biology, MedicineProceedings of the National Academy of Sciences…
- 13 March 2001
Differences in allelic associations may point to discrete attributes of the two alleles in their ability to alter folate and one-carbon metabolite pools and impact after DNA synthesis and methylation pathways, but should be viewed cautiously pending larger follow-up studies.
Mechanisms of clonal evolution in childhood acute lymphoblastic leukemia
- S. Swaminathan, Lars Klemm, M. Müschen
- Biology, MedicineNature Immunology
- 27 March 2015
It is demonstrated that AID and RAG1-RAG2 drove leukemic clonal evolution with repeated exposure to inflammatory stimuli, paralleling chronic infections in childhood.
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