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Desipramine Hydrochloride

Known as: Desipramine Hydrochloride [Chemical/Ingredient], Hydrochloride, Desipramine, desipramine hcl 
The hydrochloride salt form of desipramine, a secondary amine tricyclic antidepressant (TCA). In the central nervous system (CNS), desipramine… 
National Institutes of Health

Related topics

Related topics

15 relations
Affective Disorders, PsychoticAntidepressive AgentsAttention deficit hyperactivity disorderCytochrome P450 2D6, human

Broader (1)

Desipramine

Narrower (2)

NorpraminPertofrane

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
1999
Highly Cited
1999
Desipramine in opioid-dependent cocaine abusers maintained on buprenorphine vs methadone.
BACKGROUND Cocaine abuse occurs in 40% to 60% of patients entering opioid maintenance treatment, and effective pharmacotherapies… 
Highly Cited
1992
Highly Cited
1992
Pharmacotherapy for cocaine-abusing methadone-maintained patients using amantadine or desipramine.
In a double-blind, placebo-controlled 12-week randomized clinical trial, we compared amantadine hydrochloride (300 mg/d; n = 33… 
Highly Cited
1992
Highly Cited
1992
Desipramine treatment of cocaine dependence in methadone-maintained patients.
We performed a double-blind, placebo-controlled, randomized 12-week trial of desipramine hydrochloride treatment of cocaine… 
Highly Cited
1991
Highly Cited
1991
A preliminary, open study of the combination of fluoxetine and desipramine for rapid treatment of major depression.
Prompted by a recent study suggesting that the combination of desipramine hydrochloride and fluoxetine down-regulates beta… 
Highly Cited
1991
Highly Cited
1991
A double-blind desipramine substitution during long-term clomipramine treatment in children and adolescents with obsessive-compulsive disorder.
Twenty-six children and adolescents with severe primary obsessive-compulsive disorder receiving long-term clomipramine… 
Highly Cited
1990
Highly Cited
1990
Successful treatment of nonpurging bulimia nervosa with desipramine: a double-blind, placebo-controlled study.
Twenty-three women with nonpurging bulimia underwent a 12-week, double-blind, placebo-controlled trial of desipramine… 
Highly Cited
1986
Highly Cited
1986
Treating bulimia with desipramine. A double-blind, placebo-controlled study.
A controlled study in patients with bulimia demonstrated a significant benefit from desipramine hydrochloride treatment (91… 
Highly Cited
1984
Highly Cited
1984
Cocaine abuse treatment. Open pilot trial with desipramine and lithium carbonate.
We conducted an open clinical trial of desipramine hydrochloride or lithium carbonate as adjuncts to psychotherapy in cocaine… 
Highly Cited
1982
Highly Cited
1982
Alteration of norepinephrine metabolism with desipramine and zimelidine in depressed patients.
Twelve patients with a major affective disorder were treated during the depressed phase of their illness with desipramine… 
Highly Cited
1981
Highly Cited
1981
Presynaptic adrenergic receptor sensitivity in depression. The effect of long-term desipramine treatment.
Stimulation of presynaptic alpha 2-adrenergic receptors located on norepinephrine (NE)-containing cells in the brain decreases… 
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