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Pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections: clinical description of the first 50 cases.
OBJECTIVE The purpose of this study was to describe the clinical characteristics of a novel group of patients with obsessive-compulsive disorder (OCD) and tic disorders, designated as pediatricExpand
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A double-blind comparison of clomipramine and desipramine in the treatment of trichotillomania (hair pulling)
Trichotillomania, an irresistible impulse to pull out one's own hair, is a chronic psychiatric illness that causes severe discomfort, interferes with daily activities, and leads to social isolation.Expand
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Therapeutic plasma exchange and intravenous immunoglobulin for obsessive-compulsive disorder and tic disorders in childhood
BACKGROUND In children, exacerbations of tics and obsessive symptoms may occur after infection with group A beta-haemolytic streptococci. If post-streptococcal autoimmunity is the cause of theExpand
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Cerebral glucose metabolism in childhood-onset obsessive-compulsive disorder.
The cerebral metabolic rate for glucose was studied in 18 adults with childhood-onset obsessive-compulsive disorder (OCD) and in age- and sex-matched controls using positron emission tomography andExpand
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Sydenham's chorea. A model for childhood autoimmune neuropsychiatric disorders.
SELECTED CASE Faith (not her real name), a 9-year-old girl, presented to the local hospital's emergency department with a chief complaint of "St Vitus' dance." Her grandfather had noticed her clumsyExpand
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Mimicry and autoantibody-mediated neuronal cell signaling in Sydenham chorea
Streptococcus pyogenes–induced acute rheumatic fever (ARF) is one of the best examples of postinfectious autoimmunity due to molecular mimicry between host and pathogen. Sydenham chorea is the majorExpand
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Obsessive-compulsive disorder in children and adolescents. Clinical phenomenology of 70 consecutive cases.
We reviewed the phenomenology of obsessive-compulsive disorder (OCD) in 70 consecutive children and adolescents studied prospectively at the National Institute of Mental Health, Bethesda, Md, betweenExpand
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Tics and Tourette's disorder: a 2- to 7-year follow-up of 54 obsessive-compulsive children.
OBJECTIVE This study examined a hypothesized etiologic relationship between Tourette's disorder and obsessive-compulsive disorder. METHOD Fifty-four children who had initially participated inExpand
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Rates of seasonal affective disorder in children and adolescents.
OBJECTIVE The authors estimated the frequency of seasonal affective disorder in children and adolescents and examined the relationship of this rate to age and pubertal status. METHOD A modifiedExpand
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A 2- to 7-year follow-up study of 54 obsessive-compulsive children and adolescents.
OBJECTIVE Due to the generally poor prognosis previously reported for patients with obsessive-compulsive disorder (OCD), this report systematically assessed the outcome of patients who had had accessExpand
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