• Publications
  • Influence
Dynamic mapping of human cortical development during childhood through early adulthood.
TLDR
The dynamic anatomical sequence of human cortical gray matter development between the age of 4-21 years using quantitative four-dimensional maps and time-lapse sequences reveals that higher-order association cortices mature only after lower-order somatosensory and visual cortices are developed.
Brain development during childhood and adolescence: a longitudinal MRI study
TLDR
This large-scale longitudinal pediatric neuroimaging study confirmed linear increases in white matter, but demonstrated nonlinear changes in cortical gray matter, with a preadolescent increase followed by a postadolescent decrease.
Neurodevelopmental Trajectories of the Human Cerebral Cortex
TLDR
By mapping a key characteristic of these development trajectories (the age of attaining peak cortical thickness), this work documents the dynamic, heterochronous maturation of the cerebral cortex through time lapse sequences (“movies”).
Developmental trajectories of brain volume abnormalities in children and adolescents with attention-deficit/hyperactivity disorder.
TLDR
Developmental trajectories for all structures, except caudate, remain roughly parallel for patients and controls during childhood and adolescence, suggesting that genetic and/or early environmental influences on brain development in ADHD are fixed, nonprogressive, and unrelated to stimulant treatment.
Attention-deficit/hyperactivity disorder is characterized by a delay in cortical maturation
TLDR
Maturation to progress in a similar manner regionally in both children with and without ADHD, with primary sensory areas attaining peak cortical thickness before polymodal, high-order association areas, and there was a marked delay in ADHD in attainingpeak thickness throughout most of the cerebrum.
Intellectual ability and cortical development in children and adolescents
TLDR
This study indicates that the neuroanatomical expression of intelligence in children is dynamic, and finds a marked developmental shift from a predominantly negative correlation between intelligence and cortical thickness in early childhood to a positive correlation in late childhood and beyond.
A Developmental Functional MRI Study of Prefrontal Activation during Performance of a Go-No-Go Task
TLDR
Although inhibitory processes have typically been associated with more ventral or orbital frontal regions, the current study revealed activation that was distributed across both dorsolateral and orbitofrontal cortices, consistent with animal and human lesion studies.
Quantitative brain magnetic resonance imaging in attention-deficit hyperactivity disorder.
TLDR
This first comprehensive morphometric analysis is consistent with hypothesized dysfunction of right-sided prefrontal-striatal systems in ADHD.
Rare Structural Variants Disrupt Multiple Genes in Neurodevelopmental Pathways in Schizophrenia
TLDR
The results suggest that multiple, individually rare mutations altering genes in neurodevelopmental pathways contribute to schizophrenia, and disrupted genes disproportionately from signaling networks controlling neurodevelopment, including neuregulin and glutamate pathways.
Obsessive compulsive disorder in adolescence: an epidemiological study.
In the second part of a two-stage epidemiologic study of obsessive-compulsive symptoms in nonreferred adolescents, clinicians interviewed high school students selected from screening measures
...
...