The Yale-Brown Obsessive Compulsive Scale. I. Development, use, and reliability.
- W. Goodman, L. Price, D. Charney
- Psychology, MedicineArchives of General Psychiatry
- 1 November 1989
In a study involving four raters and 40 patients with obsessive-compulsive disorder at various stages of treatment, interrater reliability for the total Yale-Brown Scale score and each of the 10 individual items was excellent, with high degree of internal consistency among all item scores demonstrated with Cronbach's alpha coefficient.
Antidepressant effects of ketamine in depressed patients
- R. Berman, A. Cappiello, J. Krystal
- Psychology, MedicineBiological Psychiatry
- 15 February 2000
The Yale-Brown Obsessive Compulsive Scale. II. Validity.
- W. Goodman, L. Price, D. Charney
- PsychologyArchives of General Psychiatry
- 1 November 1989
Results from a previously reported placebo-controlled trial of fluvoxamine in 42 patients with obsessive-compulsive disorder showed that the Yale- Brown Scale was sensitive to drug-induced changes and that reductions in Yale-Brown Scale scores specifically reflected improvement in obsessive- compulsive disorder symptoms.
Subanesthetic effects of the noncompetitive NMDA antagonist, ketamine, in humans. Psychotomimetic, perceptual, cognitive, and neuroendocrine responses.
- J. Krystal, L. Karper, D. Charney
- Psychology, MedicineArchives of General Psychiatry
- 1 March 1994
These data indicate that N-methyl-D-aspartate antagonists produce a broad range of symptoms, behaviors, and cognitive deficits that resemble aspects of endogenous psychoses, particularly schizophrenia and dissociative states.
A molecular and cellular theory of depression.
- R. Duman, G. Heninger, E. Nestler
- Biology, PsychologyArchives of General Psychiatry
- 1 July 1997
These findings constitute the framework for an updated molecular and cellular hypothesis of depression, which posits that stress-induced vulnerability and the therapeutic action of antidepressant treatments occur via intracellular mechanisms that decrease or increase, respectively, neurotrophic factors necessary for the survival and function of particular neurons.
Serotonin function and the mechanism of antidepressant action. Reversal of antidepressant-induced remission by rapid depletion of plasma tryptophan.
- P. Delgado, D. Charney, L. Price, G. Aghajanian, H. Landis, G. Heninger
- Psychology, BiologyArchives of General Psychiatry
- 1 May 1990
The behavioral effects of rapid tryptophan depletion in patients in antidepressant-induced remission and the therapeutic effects of some antidepressant drugs may be dependent on serotonin availability are investigated.
Tryptophan Depletion During Continuous CSF Sampling in Healthy Human Subjects
- L. Carpenter, G. Anderson, C. McDougle
- BiologyNeuropsychopharmacology
- 1 July 1998
Abnormal noradrenergic function in posttraumatic stress disorder.
- S. Southwick, J. Krystal, D. Charney
- Psychology, BiologyArchives of General Psychiatry
- 1 April 1993
In the patients with PTSD, yohimbine induced significant increases in core PTSD symptoms, such as intrusive traumatic thoughts, emotional numbing, and grief, consistent with a large body of preclinical data that indicated that uncontrollable stress produces substantial increases in noradrenergic neuronal function.
Yale-Brown Obsessive Compulsive Scale (Y-BOCS)
- W. Goodman, S. Rasmussen, L. Price, L. Mazure, G. Heninger, D. Charney
- Psychology
- 1 July 1991
This rating scale is designed to rate the severity and type of symptoms in patients with obsessive compulsive disorder (OCD). In general, the items depend on the patient's report; however, the final…
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