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Cytochrome P450 2D6, human

Known as: Cytochrome P450, Subfamily IID, Xenobiotic Monooxygenase, P450-DB1 
Cytochrome P450 2D6 (497 aa, ~56 kDa) is encoded by the human CYP2D6 gene. This protein plays a role in flavoprotein metabolism.
National Institutes of Health

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AmitriptylineAmphetamine SulfateBisoprolol FumarateCYP2D6 gene

Broader (1)

Cytochrome P-450 CYP2D6

Papers overview

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Highly Cited
2012
Highly Cited
2012
Metabolism of 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine by Mitochondrion-targeted Cytochrome P450 2D6
Background: Metabolism of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) to toxic MPP+ is critical in chemically induced… 
2012
2012
Pharmacophore, QSAR, and binding mode studies of substrates of human cytochrome P450 2D6 (CYP2D6) using molecular docking and virtual mutations and an application to chinese herbal medicine screening…
The highly polymorphic human cytochrome P450 2D6 (CYP2D6) metabolizes about 25% of currently used drugs. In this study, we have… 
2008
2008
Genetic polymorphism of hepatocyte nuclear factor‐4α influences human cytochrome P450 2D6 activity
Hepatocyte nuclear factor‐4 alpha (HNF4A) is an essential transcriptional regulator for many genes that are expressed… 
Highly Cited
2004
Highly Cited
2004
Clinical significance of the sparteine/debrisoquine oxidation polymorphism
SummaryThe sparteine/debrisoquine oxidation polymorphism results from differences in the activity of one isozyme of cytochrome… 
1995
1995
A novel cytochrome P-450IID6 (CYPIID6) mutant gene associated with multiple system atrophy.
two previous reports.' 2There are at least three possible explanations. Firstly, the method employed here-a cancellation task-has… 
1994
1994
Marine natural products. XXXIII. Theonellapeptolide IId, a new tridecapeptide lactone from the Okinawan marine sponge Theonella swinhoei.
Following the characterization of theonellapeptolides Ia-Ie (2-6), another new tridecapeptide lactone named theonellapeptolide… 
1994
1994
Selective inhibition of major drug metabolizing cytochrome P450 isozymes in human liver microsomes by carbon monoxide.
Review
1992
Review
1992
Host factors in lung cancer risk: a review of interdisciplinary studies.
Host-specific factors influence risk for lung cancer. A few case-control and family studies of lung cancer susceptibility allowed… 
Highly Cited
1987
Highly Cited
1987
Debrisoquine 4-hydroxylase: characterization of a new P450 gene subfamily, regulation, chromosomal mapping, and molecular analysis of the DA rat polymorphism.
Debrisoquine 4-hydroxylase (P450db1) was purified from rat liver microsomes. Polyclonal antibody was produced and, in conjunction… 
Highly Cited
1987
Highly Cited
1987
MPTP, the neurotoxin inducing Parkinson's disease, is a potent competitive inhibitor of human and rat cytochrome P450 isozymes (P450bufI, P450db1) catalyzing debrisoquine 4-hydroxylation.
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