Cytochrome P450 2D6, human

Known as: Cytochrome P450, Subfamily IID, Xenobiotic Monooxygenase, P450-DB1 
Cytochrome P450 2D6 (497 aa, ~56 kDa) is encoded by the human CYP2D6 gene. This protein plays a role in flavoprotein metabolism.

Topic mentions per year

Topic mentions per year

1992-2018
024619922018

Papers overview

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2016
2016
The cytochrome P450-2D6 (CYP2D6) enzyme metabolizes ∼25% of common medications, yet homologous pseudogenes and copy number… (More)
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2012
2012
A ligand-based method based on the SMARTCyp approach that predicts the sites of cytochrome P450 2D6-mediated metabolism of… (More)
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2011
2011
INTRODUCTION CYP2D6 is a liver enzyme that metabolizes more that 25% of drugs and thus may play a pivotal role in drug-drug… (More)
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2010
2010
While neuropsychological deficits are evident among methamphetamine (meth) addicts, they are often unrelated to meth exposure… (More)
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Highly Cited
2006
Highly Cited
2006
Cytochrome P450 2D6 is a heme-containing enzyme that is responsible for the metabolism of at least 20% of known drugs. Substrates… (More)
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2006
2006
Methods for Cytochrome P450-2D6 (CYP2D6) genotyping are often time-consuming and laborious, which can restrict their use in… (More)
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2003
2003
Cytochrome P450 2D6 (CYP2D6) metabolizes a wide range of therapeutic drugs. CYP2D6 substrates typically contain a basic nitrogen… (More)
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2002
2002
Cytochrome P450 (P450) 2D6 is involved in the oxidation of a large fraction ( 30%) of drugs used by humans and also catalyzes the… (More)
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1999
1999
BACKGROUND Biotransformation of citalopram (CT), a newly available selective serotonin reuptake inhibitor antidepressant, to its… (More)
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1998
1998
Pharmacokinetic drug interactions with viral protease inhibitors are of potential clinical importance. An in vitro model was… (More)
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