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Association between lung cancer and microsomal epoxide hydrolase genotypes.
- S. Benhamou, M. Reinikainen, C. Bouchardy, P. Dayer, A. Hirvonen
- Biology, MedicineCancer research
- 1 December 1998
The effect of mEH activity on lung cancer risk was not significantly modified by smoking exposure, CYP1A1 genotype, or GSTM1 genotypes, and mEH may be an important genetic determinant of smoking-induced lung cancer.
Cytochrome P450TB (CYP2C): a major monooxygenase catalyzing diclofenac 4'-hydroxylation in human liver.
Codeine intoxication associated with ultrarapid CYP2D6 metabolism.
- Y. Gasche, Y. Daali, J. Desmeules
- Medicine, BiologyThe New England journal of medicine
- 30 December 2004
CYP2D6 genotyping showed that the patient had three or more functional alleles, a finding consistent with ultrarapid metabolism of codeine, and attribute the toxicity to this genotype in combination with inhibition of CYP3A4 activity by other medications and a transient reduction in renal function.
In vitro comparative inhibition profiles of major human drug metabolising cytochrome P450 isozymes (CYP2C9, CYP2D6 and CYP3A4) by HMG-CoA reductase inhibitors
Fluvastatin selectively inhibits a major drug metabolising enzyme (CYP2C9), the (+)-isomer (pharmacologically more active) showing 4–5 fold higher affinity.
Role of alcohol dehydrogenase 3 and cytochrome P‐4502E1 genotypes in susceptibility to cancers of the upper aerodigestive tract
- C. Bouchardy, A. Hirvonen, C. Coutelle, P. Ward, P. Dayer, S. Benhamou
- MedicineInternational journal of cancer
- 1 September 2000
This study suggests that CYP2E1 genotype modifies the risk of UAT cancers, but due to the low frequency of CYP 2E1 variant alleles, large‐scale studies are needed to confirm the findings.
In vitro forecasting of drugs which may interfere with the biotransformation of midazolam
Midazolam hydroxylations in vitro are inhibited by many drugs, including nifedipine and other dihydropyridine-type calcium channel blockers, ergot alkaloids, cyclosporine, erythromycin and phenothiazine-type neuroleptics.
Drug-induced long QT syndrome in injection drug users receiving methadone: high frequency in hospitalized patients and risk factors.
QT interval prolongation in methadone maintenance patients hospitalized in a tertiary care center is a frequent finding.
The kidney in maturity onset diabetes mellitus: a clinical study of 510 patients.
The results revealed an evolution which is quite different from that seen in juvenile onset, insulin-dependent diabetes mellitus, andphasis in this study was placed on hypertension, frequently observed in patients, and on quantitative as well as qualitative protein excretion, which provide a useful marker of glomerular or tubule dysfunction when analyzed according to the molecular weight of the various fractions excreted.
Bioactivation of the narcotic drug codeine in human liver is mediated by the polymorphic monooxygenase catalyzing debrisoquine 4-hydroxylation (cytochrome P-450 dbl/bufI).
CYP2E1 genotype and isoniazid-induced hepatotoxicity in patients treated for latent tuberculosis
- N. Vuilleumier, M. Rossier, D. Hochstrasser
- Medicine, BiologyEuropean Journal of Clinical Pharmacology
- 27 April 2006
The genotyping of CYP2E1 polymorphisms may be a useful predictive tool in the common setting of a highly heterogeneous population for predicting isoniazid-induced hepatic toxicity in a cosmopolite population.