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Association between lung cancer and microsomal epoxide hydrolase genotypes.
TLDR
The effect of mEH activity on lung cancer risk was not significantly modified by smoking exposure, CYP1A1 genotype, or GSTM1 genotypes, and mEH may be an important genetic determinant of smoking-induced lung cancer.
Codeine intoxication associated with ultrarapid CYP2D6 metabolism.
TLDR
CYP2D6 genotyping showed that the patient had three or more functional alleles, a finding consistent with ultrarapid metabolism of codeine, and attribute the toxicity to this genotype in combination with inhibition of CYP3A4 activity by other medications and a transient reduction in renal function.
In vitro comparative inhibition profiles of major human drug metabolising cytochrome P450 isozymes (CYP2C9, CYP2D6 and CYP3A4) by HMG-CoA reductase inhibitors
TLDR
Fluvastatin selectively inhibits a major drug metabolising enzyme (CYP2C9), the (+)-isomer (pharmacologically more active) showing 4–5 fold higher affinity.
Role of alcohol dehydrogenase 3 and cytochrome P‐4502E1 genotypes in susceptibility to cancers of the upper aerodigestive tract
TLDR
This study suggests that CYP2E1 genotype modifies the risk of UAT cancers, but due to the low frequency of CYP 2E1 variant alleles, large‐scale studies are needed to confirm the findings.
In vitro forecasting of drugs which may interfere with the biotransformation of midazolam
TLDR
Midazolam hydroxylations in vitro are inhibited by many drugs, including nifedipine and other dihydropyridine-type calcium channel blockers, ergot alkaloids, cyclosporine, erythromycin and phenothiazine-type neuroleptics.
Drug-induced long QT syndrome in injection drug users receiving methadone: high frequency in hospitalized patients and risk factors.
TLDR
QT interval prolongation in methadone maintenance patients hospitalized in a tertiary care center is a frequent finding.
The kidney in maturity onset diabetes mellitus: a clinical study of 510 patients.
TLDR
The results revealed an evolution which is quite different from that seen in juvenile onset, insulin-dependent diabetes mellitus, andphasis in this study was placed on hypertension, frequently observed in patients, and on quantitative as well as qualitative protein excretion, which provide a useful marker of glomerular or tubule dysfunction when analyzed according to the molecular weight of the various fractions excreted.
CYP2E1 genotype and isoniazid-induced hepatotoxicity in patients treated for latent tuberculosis
TLDR
The genotyping of CYP2E1 polymorphisms may be a useful predictive tool in the common setting of a highly heterogeneous population for predicting isoniazid-induced hepatic toxicity in a cosmopolite population.
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