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Marine natural products. XXXIV. Trisindoline, a new antibiotic indole trimer, produced by a bacterium of Vibrio sp. separated from the marine sponge Hyrtios altum.
TLDR
A new antibiotic indole trimer was isolated, together with a known dioxopiperazine brevianamide F, from the culture of a bacterium of Vibrio sp.
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Novel neuronal nitric oxide synthase (nNOS) selective inhibitor, aplysinopsin-type indole alkaloid, from marine sponge Hyrtios erecta.
TLDR
Two novel aplysinopsin-type indole alkaloids and new quinolone 7 were isolated from the marine sponge Hyrtios erecta and exhibited selective inhibitory activity against the neuronal isozyme of nitric oxide synthase.
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Indonesian medicinal plants. XVII. Characterization of quassinoids from the stems of Quassia indica.
TLDR
Four new quassinoids named samaderines X (1), Y (2) and Z (3), and indaquassin X (5), and a new C19 quassinoid glycoside, 2-O-glucosylsamaderine C (10), together with five known quassin steroids, were isolated form the stems of Quassia indica (Simaroubaceae), an Indonesian medicinal plant.
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New anti-malarial flavonol glycoside from Hydrangeae Dulcis Folium.
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Antifungal peroxyketal acids from an Okinawan marine sponge of Plakortis sp.
TLDR
The absolute stereostructures 1-5 have been elucidated on the basis of chemical and physicochemical evidence.
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Marine natural products. XXXII. Absolute configurations of C-4 of the manoalide family, biologically active sesterterpenes from the marine sponge Hyrtios erecta.
TLDR
Manoalide 25-acetals were shown to exhibit in vivo antitumor activity and to inhibit theDNA-relaxing activity of mouse DNA topoisomerase I and the DNA-unknotting activity of calf thymus DNA top Loisomerase II.
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4-Aza-2,3-dehydro-4-deoxypodophyllotoxins: simple aza-podophyllotoxin analogues possessing potent cytotoxicity.
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Altohyrtins B and C and 5-desacetylaltohyrtin A, potent cytotoxic macrolide congeners of altohyrtin A, from the Okinawan marine sponge Hyrtios altum.
TLDR
Three congeneric macrolides exhibit extremely potent cytotoxicities similar to those of 1 against KB cells with IC50 values of 0.02, 0.4, and 0.3 ng/ml, respectively.
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Indonesian medicinal plants. XXI. Inhibitors of Na+/H+ exchanger from the bark of Erythrina variegata and the roots of Maclura cochinchinensis.
TLDR
Through bioassay-guided separation of the methanol extracts of Indonesian medicinal plants, three inhibitors of the Na+/H+ exchange system, erythrinin B, euchrenone b10, and 1,3,5-trihydroxy-4-(3-methylbut-2-enyl)xanthen-9-one (4) were isolated and the chemical structures were elucidated on the bases of their chemical and physicochemical properties.
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Indonesian Medicinal Plants. XIV. Characterization of 3'-O-Caffeoylsweroside, a new secoiridoid glucoside, and kelampayosides A and B, two new phenolic apioglucosides, from the bark of Anthocephalus…
TLDR
Cadambine (13), one of the major indole alkaloid constituents of A. chinensis, was shown to exhibit moderate growth-inhibitory activity against the malarial parasite Plasmodium falciparum cultured in human erythrocytes.
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