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CYP2D6 gene

Known as: Cytochrome P450, Family 2, Subfamily D, Polypeptide 6 Gene, P450-DB1, cytochrome P450 family 2 subfamily D member 6 
This gene plays a role in the metabolism of numerous clinically-relevant drugs. It is also involved in the oxidation of xenobiotics.
National Institutes of Health

Papers overview

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Highly Cited
2003
Highly Cited
2003
The ligand-binding characteristics of rat and human CYP2D isoforms, i.e., rat CYP2D1-4 and human CYP2D6, were investigated by… Expand
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Highly Cited
1999
Highly Cited
1999
The polymorphic CYP2D6 gene determines the rates at which several different classes of clinically important drugs are metabolized… Expand
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Highly Cited
1998
Highly Cited
1998
Dopamine is formed form L-tyrosine by tyrosine hydroxylase and aromatic L-amino acid decarboxylase. In addition to this pathway… Expand
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Highly Cited
1996
Highly Cited
1996
The debrisoquine hydroxylase (CYP2D6) catalyzes the oxidative metabolism of more than 40 different clinically important drugs… Expand
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Highly Cited
1995
Highly Cited
1995
The cytochrome P450 enzyme debrisoquine 4-hydroxylase metabolizes many different classes of commonly used drugs, such as… Expand
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Highly Cited
1994
Highly Cited
1994
Cytochrome P4502D6 (CYP2D6) catalyzes the oxidative metabolism of several clinically important classes of drugs. Many of these… Expand
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Highly Cited
1993
Highly Cited
1993
Deficient hydroxylation of debrisoquine is an autosomal recessive trait that affects approximately 7% of the Caucasian population… Expand
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Highly Cited
1991
Highly Cited
1991
The debrisoquine/sparteine polymorphism is associated with a clinically important genetic deficiency of oxidative drug metabolism… Expand
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Highly Cited
1989
Highly Cited
1989
The debrisoquine-4-hydroxylase polymorphism is a genetic variation in oxidative drug metabolism characterized by two phenotypes… Expand
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Highly Cited
1988
Highly Cited
1988
The enzyme P450db1 (db1) is responsible for the common human defect in drug oxidation known as the "debrisoquine/sparteine… Expand
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