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CYP2D6 gene

Known as: Cytochrome P450, Family 2, Subfamily D, Polypeptide 6 Gene, P450-DB1, cytochrome P450 family 2 subfamily D member 6 
This gene plays a role in the metabolism of numerous clinically-relevant drugs. It is also involved in the oxidation of xenobiotics.
National Institutes of Health

Related topics

Related topics

15 relations
AromataseCYP2D6*7 AlleleCytochrome P-450 CYP1A1Cytochrome P-450 CYP1A2

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CYP2D6 wt Allele

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2014
2014
Deletion of 30 Murine Cytochrome P450 Genes Results In Viable Mice With Compromised Drug Metabolism
In humans, 75% of all drugs are metabolized by the cytochrome P450-dependent monooxygenase system. Enzymes encoded by the CYP2C… 
2010
2010
Molecular cloning and expression of cytochrome P450 2D6 in the livers of domestic cats.
Cytochrome P450 2D (CYP2D) is one of the major metabolizing enzymes for drugs in humans and other mammals. Although domestic cats… 
2007
2007
A Natural Variant of the Heme-Binding Signature (R441C) Resulting in Complete Loss of Function of CYP2D6
A new variant allele CYP2D6*62 (g.4044C>T; R441C) of the drug-metabolizing cytochrome P450 (P450) CYP2D6 was identified in a… 
2004
2004
Cloning and functional expression of a novel marmoset cytochrome P450 2D enzyme, CYP2D30: comparison with the known marmoset CYP2D19.
2003
2003
Demethylation of radiolabelled dextromethorphan in rat microsomes and intact hepatocytes.
Liver microsomal preparations are routinely used to predict drug interactions that can occur in vivo as a result of inhibition of… 
1998
1998
Cytochrome P450 CYP2D6 gene polymorphism and lung cancer susceptibility in Caucasians.
Many studies have been performed in an attempt to establish a link between the polymorphism of the cytochrome P450 CYP2D6 gene… 
1997
1997
Regulation of expression of cytochrome P-450 2D mRNA in rat brain with steroid hormones
1997
1997
Molecular heterogeneity at the CYP2D gene locus in Nicaraguans: impact of gene-flow from Europe.
1995
1995
An unequal cross-over event within the CYP2D gene cluster generates a chimeric CYP2D7/CYP2D6 gene which is associated with the poor metabolizer phenotype.
1. The study of the CYP2D genotype and phenotype of a Caucasian family revealed that a XbaI-9 kb allele was associated with the… 
1993
1993
In vivo evidence that theophylline is metabolized principally by CYP1A in rats.
The role of various subfamilies of rat hepatic cytochrome P-450 in the oxidation of theophylline was evaluated by comparing… 
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