CYP2D6 gene

Known as: Cytochrome P450, Family 2, Subfamily D, Polypeptide 6 Gene, P450-DB1, cytochrome P450 family 2 subfamily D member 6 
This gene plays a role in the metabolism of numerous clinically-relevant drugs. It is also involved in the oxidation of xenobiotics.
National Institutes of Health

Papers overview

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2002
2002
1. Chronic renal failure (CRF) is associated with a decrease in liver cytochrome p450 (p450). The mechanism remains poorly… (More)
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2001
Highly Cited
2001
CYP2D6 is a highly polymorphic human gene responsible for a large variability in the disposition of more than 100 drugs to which… (More)
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1999
Highly Cited
1999
The polymorphic CYP2D6 gene determines the rates at which several different classes of clinically important drugs are metabolized… (More)
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1998
Highly Cited
1998
Dopamine is formed form L-tyrosine by tyrosine hydroxylase and aromatic L-amino acid decarboxylase. In addition to this pathway… (More)
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1997
1997
1. A molecular model of CYP2D6 has been constructed from the bacterial form CYP102 via a homology alignment between the CYP2D… (More)
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1996
Highly Cited
1996
The debrisoquine hydroxylase (CYP2D6) catalyzes the oxidative metabolism of more than 40 different clinically important drugs… (More)
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1995
Highly Cited
1995
The cytochrome P450 enzyme debrisoquine 4-hydroxylase metabolizes many different classes of commonly used drugs, such as… (More)
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1992
1992
The CYP2D gene cluster on human chromosome 22 containing the functional cytochrome P450 gene CYP2D6 and two or three highly… (More)
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1990
1990
The debrisoquine polymorphism is a common genetic defect that results in deficient oxidation of debrisoquine and numerous other… (More)
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1989
Highly Cited
1989
The debrisoquine-4-hydroxylase polymorphism is a genetic variation in oxidative drug metabolism characterized by two phenotypes… (More)
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