Skip to search formSkip to main contentSkip to account menu

CYP2D6 wt Allele

Known as: P450C2D, CPD6, P450-DB1 
Human CYP2D6 wild-type allele is located in the vicinity of 22q13.1 and is approximately 4 kb in length. This allele, which encodes cytochrome P450… 
National Institutes of Health

Related topics

Related topics

11 relations
22q13.1Cytochrome P-450 CYP2D6Homo sapiensIron Chelation

Broader (1)

CYP2D6 gene

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2010
Review
2010
Cytochrome P450-mediated hepatic metabolism of new fluorescent substrates in cats and dogs.
This study aimed to investigate the biotransformation of cat liver microsomes in comparison to dogs and humans using a high… 
2007
2007
Characterization of cytochrome P450-mediated drug metabolism in cats.
In this study we examined activities of cytochrome P450 (CYP)1A, 2C, 2D and 3A using hepatic microsomes from five male and five… 
2007
2007
A Natural Variant of the Heme-Binding Signature (R441C) Resulting in Complete Loss of Function of CYP2D6
A new variant allele CYP2D6*62 (g.4044C>T; R441C) of the drug-metabolizing cytochrome P450 (P450) CYP2D6 was identified in a… 
2003
2003
Phenytoin–Diazepam Interaction
OBJECTIVE: To report a case of phenytoin toxicity potentially associated with concurrent diazepam therapy. CASE SUMMARY: A 44… 
2001
2001
Inactivation of rat cytochrome P450 2D enzyme by a further metabolite of 4-hydroxypropranolol, the major and active metabolite of propranolol.
Repetitive administration of propranolol (PL) in rats decreases the activities of cytochrome P450 (CYP) 2D enzyme(s) in hepatic… 
2001
2001
Characterization of xenobiotic-metabolizing cytochrome P450 (CYP) forms in ringed and grey seals from the Baltic Sea and reference sites.
1997
1997
Marmoset liver cytochrome P450s: study for expression and molecular cloning of their cDNAs.
Northern blot and immunoblot analyses indicated that considerable levels of CYP2B, CYP2C, CYP2D, CYP2E, and CYP3A were expressed… 
Highly Cited
1996
Highly Cited
1996
Localization of an ovarian cancer tumor suppressor gene to a 0.5-cM region between D22S284 and CYP2D, on chromosome 22q.
The detection of loss of heterozygosity, indicative of the presence of a tumor suppressor gene, has been reported to occur… 
1996
1996
The CYP2D Subfamily
1995
1995
An unequal cross-over event within the CYP2D gene cluster generates a chimeric CYP2D7/CYP2D6 gene which is associated with the poor metabolizer phenotype.
1. The study of the CYP2D genotype and phenotype of a Caucasian family revealed that a XbaI-9 kb allele was associated with the… 
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)