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CYP2D6 wt Allele

Known as: P450C2D, CPD6, P450-DB1 
Human CYP2D6 wild-type allele is located in the vicinity of 22q13.1 and is approximately 4 kb in length. This allele, which encodes cytochrome P450… Expand
National Institutes of Health

Papers overview

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2011
2011
The cytochrome P450 (P450) family of enzymes is a major player in the metabolism of therapeutic drugs available on the market… Expand
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2010
2010
The effects of regular organic solvents on the metabolic activities of various human cytochromes P450 (P450s) have been reported… Expand
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Highly Cited
2005
Highly Cited
2005
Great interindividual variability in drug response leads to variation in drug safety and efficacy. Although this can be the… Expand
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Highly Cited
2002
Highly Cited
2002
Cytochrome P450 (CYP) 2D6 is expressed in liver, brain and other extrahepatic tissues where it metabolizes a range of centrally… Expand
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Highly Cited
2001
Highly Cited
2001
Chronic renal failure (CRF) is associated with a decrease in drug metabolism. The mechanism remains poorly understood. The… Expand
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1999
1999
The cytochrome P450 2D6 (CYP2D6) genotypes and phenotypes of 106 unrelated, healthy black Tanzanians of Bantu origin were… Expand
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Highly Cited
1997
Highly Cited
1997
The polymorphic cytochrome P450 2D6 (CYP2D6) causing poor, extensive or ultrarapid metabolism of several clinically important… Expand
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Highly Cited
1996
Highly Cited
1996
We systematically characterized the levels and substrate specificity of P450s from humans and rats to extrapolate drug metabolism… Expand
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Highly Cited
1989
Highly Cited
1989
The debrisoquine-4-hydroxylase polymorphism is a genetic variation in oxidative drug metabolism characterized by two phenotypes… Expand
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1988
1988
The enzyme P450db1 (db1) is responsible for the common human defect in drug oxidation known as the "debrisoquine/sparteine… Expand
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