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CYP2D6 wt Allele

Known as: P450C2D, CPD6, P450-DB1 
Human CYP2D6 wild-type allele is located in the vicinity of 22q13.1 and is approximately 4 kb in length. This allele, which encodes cytochrome P450… 
National Institutes of Health

Related topics

Related topics

11 relations
22q13.1Cytochrome P-450 CYP2D6Homo sapiensIron Chelation

Broader (1)

CYP2D6 gene

Papers overview

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Review
2010
Review
2010
Cytochrome P450-mediated hepatic metabolism of new fluorescent substrates in cats and dogs.
This study aimed to investigate the biotransformation of cat liver microsomes in comparison to dogs and humans using a high… 
2010
2010
Pharmacokinetic interaction between tamoxifen and ondansetron in rats: non-competitive (hepatic) and competitive (intestinal) inhibition of tamoxifen metabolism by ondansetron via CYP2D subfamily and…
PurposeTamoxifen and ondansetron were commonly metabolized via rat hepatic CYP2D subfamily and 3A1/2, and ondansetron is used to… 
2007
2007
A Natural Variant of the Heme-Binding Signature (R441C) Resulting in Complete Loss of Function of CYP2D6
A new variant allele CYP2D6*62 (g.4044C>T; R441C) of the drug-metabolizing cytochrome P450 (P450) CYP2D6 was identified in a… 
2003
2003
Phenytoin–Diazepam Interaction
OBJECTIVE: To report a case of phenytoin toxicity potentially associated with concurrent diazepam therapy. CASE SUMMARY: A 44… 
2001
2001
Inactivation of rat cytochrome P450 2D enzyme by a further metabolite of 4-hydroxypropranolol, the major and active metabolite of propranolol.
Repetitive administration of propranolol (PL) in rats decreases the activities of cytochrome P450 (CYP) 2D enzyme(s) in hepatic… 
2001
2001
Characterization of xenobiotic-metabolizing cytochrome P450 (CYP) forms in ringed and grey seals from the Baltic Sea and reference sites.
2001
2001
Interaction of plasma proteins with cytochromes P450 mediated metabolic reactions: inhibition by human serum albumin and alpha-globulins of the debrisoquine 4-hydroxylation (CYP2D) in liver…
1997
1997
Marmoset liver cytochrome P450s: study for expression and molecular cloning of their cDNAs.
Northern blot and immunoblot analyses indicated that considerable levels of CYP2B, CYP2C, CYP2D, CYP2E, and CYP3A were expressed… 
1996
1996
The CYP2D Subfamily
1992
1992
Debrisoquine 4-hydroxylase (CYP2D) locus and possible susceptibility to schizophrenia
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