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CYP2D6 wt Allele

Known as: P450C2D, CPD6, P450-DB1 
Human CYP2D6 wild-type allele is located in the vicinity of 22q13.1 and is approximately 4 kb in length. This allele, which encodes cytochrome P450… 
National Institutes of Health

Related topics

Related topics

11 relations
22q13.1Cytochrome P-450 CYP2D6Homo sapiensIron Chelation

Broader (1)

CYP2D6 gene

Papers overview

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Highly Cited
2005
Highly Cited
2005
CYP2D6 genotyping by a multiplex primer extension reaction.
Great interindividual variability in drug response leads to variation in drug safety and efficacy. Although this can be the… 
Highly Cited
2003
Highly Cited
2003
Homology modeling of rat and human cytochrome P450 2D (CYP2D) isoforms and computational rationalization of experimental ligand-binding specificities.
The ligand-binding characteristics of rat and human CYP2D isoforms, i.e., rat CYP2D1-4 and human CYP2D6, were investigated by… 
Highly Cited
2003
Highly Cited
2003
CYP2D in the brain.
CYP2D1, 2D2, 2D3, and 2D4 are major CYP2D isoforms expressed in the rat. In humans, only CYP2D6 is expressed. In rat brain, the… 
Highly Cited
2002
Highly Cited
2002
Regional and cellular expression of CYP2D6 in human brain: higher levels in alcoholics
Cytochrome P450 (CYP) 2D6 is expressed in liver, brain and other extrahepatic tissues where it metabolizes a range of centrally… 
Highly Cited
2000
Highly Cited
2000
Regional and cellular distribution of CYP2D subfamily members in rat brain
1. Human CYP2D6 is present in brain, metabolizes many drugs and has been implicated in Parkinson's and Alzheimer's diseases and… 
Highly Cited
1997
Highly Cited
1997
Frequent occurrence of CYP2D6 gene duplication in Saudi Arabians.
The polymorphic cytochrome P450 2D6 (CYP2D6) causing poor, extensive or ultrarapid metabolism of several clinically important… 
Highly Cited
1996
Highly Cited
1996
Multiple forms of human P450 expressed in Saccharomyces cerevisiae. Systematic characterization and comparison with those of the rat.
Highly Cited
1994
Highly Cited
1994
Cytochrome P450 isozymes involved in propranolol metabolism in human liver microsomes. The role of CYP2D6 as ring-hydroxylase and CYP1A2 as N-desisopropylase.
Oxidative metabolic pathways of propranolol consist of naphthalene ring-hydroxylations (at the 4-, 5-, and 7-positions) and side… 
Highly Cited
1993
Highly Cited
1993
Localization of the CYP2D gene locus to human chromosome 22q13.1 by polymerase chain reaction, in situ hybridization, and linkage analysis.
Using a combination of somatic cell hybrids, in situ hybridization, and linkage mapping, we have been able to localize the… 
Highly Cited
1988
Highly Cited
1988
Human debrisoquine 4-hydroxylase (P450IID1): cDNA and deduced amino acid sequence and assignment of the CYP2D locus to chromosome 22.
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