CYP2D6 wt Allele

Known as: P450C2D, CPD6, P450-DB1 
Human CYP2D6 wild-type allele is located in the vicinity of 22q13.1 and is approximately 4 kb in length. This allele, which encodes cytochrome P450… (More)
National Institutes of Health

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Topic mentions per year

1988-2018
0102019882018

Papers overview

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Highly Cited
2001
Highly Cited
2001
Chronic renal failure (CRF) is associated with a decrease in drug metabolism. The mechanism remains poorly understood. The… (More)
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1999
1999
The polymorphic CYP2D6 gene determines the rates at which several different classes of clinically important drugs are metabolized… (More)
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Highly Cited
1998
Highly Cited
1998
Dopamine is formed form L-tyrosine by tyrosine hydroxylase and aromatic L-amino acid decarboxylase. In addition to this pathway… (More)
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Highly Cited
1996
Highly Cited
1996
We systematically characterized the levels and substrate specificity of P450s from humans and rats to extrapolate drug metabolism… (More)
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Highly Cited
1995
Highly Cited
1995
The cytochrome P450 enzyme debrisoquine 4-hydroxylase metabolizes many different classes of commonly used drugs, such as… (More)
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Highly Cited
1994
Highly Cited
1994
Cytochrome P4502D6 (CYP2D6) catalyzes the oxidative metabolism of several clinically important classes of drugs. Many of these… (More)
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Highly Cited
1993
Highly Cited
1993
Deficient hydroxylation of debrisoquine is an autosomal recessive trait that affects approximately 7% of the Caucasian population… (More)
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1992
1992
The CYP2D gene cluster on human chromosome 22 containing the functional cytochrome P450 gene CYP2D6 and two or three highly… (More)
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Highly Cited
1991
Highly Cited
1991
The debrisoquine/sparteine polymorphism is associated with a clinically important genetic deficiency of oxidative drug metabolism… (More)
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Highly Cited
1989
Highly Cited
1989
The debrisoquine-4-hydroxylase polymorphism is a genetic variation in oxidative drug metabolism characterized by two phenotypes… (More)
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