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AbstractBackgroundThe production of peroxide and superoxide is an inevitable consequence of aerobic metabolism, and while these… Expand Genetic disorders of iron metabolism and chronic inflammation often evoke local iron accumulation. In Friedreich ataxia… Expand Studies on postmortem brains from Parkinson's patients reveal elevated iron in the substantia nigra (SN). Selective cell death in… Expand Hypoxia-inducible factor (HIF) is a transcriptional complex that plays a central role in the regulation of gene expression by… Expand HIF is a transcriptional complex that plays a central role in mammalian oxygen homeostasis. Recent studies have defined… Expand AIMS
To develop and validate a non-invasive method for measuring myocardial iron in order to allow diagnosis and treatment before… Expand Hypoxia-inducible factor-1 (HIF-1) has a key role in cellular responses to hypoxia, including the regulation of genes involved in… Expand The antioxidant activity of flavonoids is believed to be caused by a combination of iron chelation and free radical scavenging… Expand Endothelial cells, macrophages, neutrophils, and neuronal cells generate superoxide (O2-) and nitric oxide (.NO) which can… Expand Superoxide dismutase reduces injury in many disease processes, implicating superoxide anion radical (O2-.) as a toxic species in… Expand