Inhibition of NADH-linked oxidation in brain mitochondria by 1-methyl-4-phenyl-pyridine, a metabolite of the neurotoxin, 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine.
Dopaminergic neurotoxicity of 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine in mice.
When MPTP (30 milligrams per kilogram of body weight) was administered parenterally to mice, a decrease in concentrations of neostriatal dopamine and its metabolites and a disappearance of nerve cells in the zona compacta of the substantia nigra were observed.
In vivo inhibition of superoxide dismutase in mice by diethyldithiocarbamate.
Protection against the dopaminergic neurotoxicity of 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine by monoamine oxidase inhibitors
It is reported that pargyline, nialamide and tranylcypromine, which inhibit both MAO-A andMAO-B, when administered to mice before MPTP, protect against MPTP-induced dopaminergic neurotoxicity.
Behavioral properties of GBR 12909, GBR 13069 and GBR 13098: specific inhibitors of dopamine uptake.
The generation of hydrogen peroxide, superoxide radical, and hydroxyl radical by 6-hydroxydopamine, dialuric acid, and related cytotoxic agents.
Studies on the distinction between uptake inhibition and release of (3H)dopamine in rat brain tissue slices.
Role for excitatory amino acids in methamphetamine-induced nigrostriatal dopaminergic toxicity.
MK-801, phencyclidine, and ketamine, noncompetitive antagonists of one subtype of excitatory amino acid receptor, the N-methyl-D-aspartate receptor, provided substantial protection against neurotoxicity produced by methamphetamine but not that produced by MPTP.
Amphetamine: evaluation of d- and l-isomers as releasing agents and uptake inhibitors for 3H-dopamine and 3H-norepinephrine in slices of rat neostriatum and cerebral cortex.
- R. Heikkila, H. Orlansky, C. Mytilineou, G. Cohen
- Biology, ChemistryJournal of Pharmacology and Experimental…
- 1 July 1975
It is concluded that in the cortex, d-amphetamine can act both to release and to block uptake of 3H-norepinephrine, and in the neostriatum, there is releasing action of 2H-dopamine by d- methamphetamine, but the apparent blockade of "uptake" is of questionable significance and appears to result from the release of previously accumulated3H- dopamine.
MPTP, MPP+ and mitochondrial function.
The studies support the hypothesis that compromise of mitochondrial oxidative capacity is an important factor in the mechanisms underlying the toxicity of MPTP and similar compounds.