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CYP11A1 gene

Known as: CYP11A, CYTOCHROME P450 SIDE-CHAIN CLEAVAGE ENZYME, CYP11A1 
This gene is involved in steroid metabolism.
National Institutes of Health

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Related topics

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CYP11A1 wt Allele
Cholesterol Monooxygenase (Side-Chain-Cleaving)Iron ChelationMetabolic Detoxication, DrugMetabolism

Papers overview

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Highly Cited
2006
Highly Cited
2006
The post-menopausal ovary displays a unique pattern of steroidogenic enzyme expression.
BACKGROUND While menopause results in the loss of cyclic steroid production, evidence exists for persistent, albeit reduced… 
2005
2005
Immunohistochemical evidence identifying the site of androgen production in the ovary of the protogynous grouper Epinephelus merra
Androgen plays an important role in the developing ovaries of female fish. However, little is known regarding either the sites of… 
Highly Cited
2002
Highly Cited
2002
Probing the interaction of bovine cytochrome P450scc (CYP11A1) with adrenodoxin: evaluating site-directed mutations by molecular modeling.
The present study was undertaken to evaluate the role of positively charged amino acid residues proposed to reside on the… 
Highly Cited
1998
Highly Cited
1998
Expression of catalytically active human cytochrome p450scc in Escherichia coli and mutagenesis of isoleucine-462.
Cytochrome P450scc (P450scc) catalyzes the first step in steroid hormone synthesis, the conversion of cholesterol to pregnenolone… 
Highly Cited
1998
Highly Cited
1998
ATP-dependent Proteolysis in Mitochondria
To analyze protein degradation in mitochondria and the role of molecular chaperone proteins in this process, bovine apocytochrome… 
Highly Cited
1997
Highly Cited
1997
Ontogeny of steroidogenic enzyme gene expression in ovarian theca-interstitial cells in the rat: regulation by a paracrine theca-differentiating factor prior to achieving luteinizing hormone…
The theca cells (TC) first become identifiable in preantral follicles after the granulosa cells (GC) begin to divide. It remains… 
Highly Cited
1991
Highly Cited
1991
2,3,7,8-Tetrachlorodibenzo-p-dioxin inhibits steroidogenesis in the rat testis by inhibiting the mobilization of cholesterol to cytochrome P450scc.
Highly Cited
1991
Highly Cited
1991
Expression of functional bovine cholesterol side chain cleavage cytochrome P450 (P450scc) in Escherichia coli.
Highly Cited
1989
Highly Cited
1989
Interferon-gamma inhibits steroidogenesis and accumulation of mRNA of the steroidogenic enzymes P450scc and P450c17 in cultured porcine Leydig cells.
The inhibitory effects of recombinant porcine interferon-gamma (IFN gamma) on human CG (hCG)-stimulated testosterone production… 
Highly Cited
1987
Highly Cited
1987
Hormonal regulation of messenger ribonucleic acids for P450scc (cholesterol side-chain cleavage enzyme) and P450c17 (17 alpha-hydroxylase/17,20-lyase) in cultured human fetal adrenal cells.
ACTH has acute and long term effects on adrenal steroidogenesis by week 14 of fetal life. We used human fetal adrenal cells to… 
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