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CYP11A1 wt Allele
Known as:
CYP11A
, Cytochrome P450, Family 11, Subfamily A, Polypeptide 1 wt Allele
, P450SCC
Human CYP11A1 wild-type allele is located within 15q23-q24 and is approximately 30 kb in length. This allele, which encodes cytochrome P450 11A1…
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National Institutes of Health
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Related topics
Related topics
9 relations
15q23-q24
Homo sapiens
Iron Chelation
Metabolic Detoxication, Drug
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Broader (1)
CYP11A1 gene
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Review
2012
Review
2012
Role of mitochondria in steroidogenesis.
V. Papadopoulos
,
W. Miller
Best practice & research. Clinical endocrinology…
2012
Corpus ID: 5865656
Highly Cited
2010
Highly Cited
2010
Cellular cholesterol delivery, intracellular processing and utilization for biosynthesis of steroid hormones
Jie Hu
,
Zhonghua Zhang
,
W. Shen
,
S. Azhar
Nutrition & metabolism
2010
Corpus ID: 16731650
Steroid hormones regulate diverse physiological functions such as reproduction, blood salt balance, maintenance of secondary…
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Highly Cited
2004
Highly Cited
2004
Adult male rat hippocampus synthesizes estradiol from pregnenolone by cytochromes P45017alpha and P450 aromatase localized in neurons.
Y. Hojo
,
T. Hattori
,
+10 authors
S. Kawato
Proceedings of the National Academy of Sciences…
2004
Corpus ID: 44182546
In adult mammalian brain, occurrence of the synthesis of estradiol from endogenous cholesterol has been doubted because of the…
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Highly Cited
2001
Highly Cited
2001
Heterozygous mutation in the cholesterol side chain cleavage enzyme (p450scc) gene in a patient with 46,XY sex reversal and adrenal insufficiency.
T. Tajima
,
K. Fujieda
,
N. Kouda
,
J. Nakae
,
W. Miller
The Journal of clinical endocrinology and…
2001
Corpus ID: 8205007
Cytochrome P450scc, the mitochondrial cholesterol side chain cleavage enzyme, is the only enzyme that catalyzes the conversion of…
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Highly Cited
2000
Highly Cited
2000
Organ-specific and non-organ-specific autoantibodies in children and young adults with autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED).
R. Perniola
,
A. Falorni
,
M. Clemente
,
F. Forini
,
E. Accogli
,
G. Lobreglio
European journal of endocrinology
2000
Corpus ID: 32025802
OBJECTIVE The aim of the study was to assess the complex of autoantibodies which can be detected in patients with autoimmune…
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Highly Cited
1999
Highly Cited
1999
Thirty-seven candidate genes for polycystic ovary syndrome: strongest evidence for linkage is with follistatin.
M. Urbanek
,
R. Legro
,
+6 authors
A. Dunaif
Proceedings of the National Academy of Sciences…
1999
Corpus ID: 25024610
Polycystic ovary syndrome (PCOS) is a common endocrine disorder of women, characterized by hyperandrogenism and chronic…
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Highly Cited
1998
Highly Cited
1998
Cytochrome P450 side-chain cleavage enzyme in the cerebellar Purkinje neuron and its neonatal change in rats.
K. Ukena
,
M. Usui
,
C. Kohchi
,
K. Tsutsui
Endocrinology
1998
Corpus ID: 8271033
Neurosteroids are de novo synthesized in the nervous system through mechanisms at least partly independent of peripheral…
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Highly Cited
1997
Highly Cited
1997
Association of the steroid synthesis gene CYP11a with polycystic ovary syndrome and hyperandrogenism.
N. Gharani
,
D. Waterworth
,
+6 authors
R. Williamson
Human molecular genetics
1997
Corpus ID: 1144983
Biochemical data implicate an underlying disorder of androgen biosynthesis and/or metabolism in the aetiology of polycystic ovary…
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Highly Cited
1991
Highly Cited
1991
Tumor necrosis factor as a potent inhibitor of adrenocorticotropin-induced cortisol production and steroidogenic P450 enzyme gene expression in cultured human fetal adrenal cells.
M. Jäättelä
,
V. Ilvesmäki
,
R. Voutilainen
,
U. Stenman
,
E. Saksela
Endocrinology
1991
Corpus ID: 23112696
We have previously demonstrated that tumor necrosis factor alpha (TNF-alpha), a multifunctional cytokine mainly produced by…
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Highly Cited
1987
Highly Cited
1987
Cytochrome P450c17 (steroid 17 alpha-hydroxylase/17,20 lyase): cloning of human adrenal and testis cDNAs indicates the same gene is expressed in both tissues.
B. Chung
,
J. Picado-Leonard
,
+4 authors
W. Miller
Proceedings of the National Academy of Sciences…
1987
Corpus ID: 35431791
P450c17 is the single enzyme mediating both 17 alpha-hydroxylase (steroid 17 alpha-monooxygenase, EC 1.14.99.9) and 17,20 lyase…
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