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CYP11A1 wt Allele

Known as: CYP11A, Cytochrome P450, Family 11, Subfamily A, Polypeptide 1 wt Allele, P450SCC 
Human CYP11A1 wild-type allele is located within 15q23-q24 and is approximately 30 kb in length. This allele, which encodes cytochrome P450 11A1… Expand
National Institutes of Health

Related topics

Related topics

9 relations
15q23-q24Homo sapiensIron ChelationMetabolic Detoxication, Drug
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Broader (1)

CYP11A1 gene

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2012
Review
2012
Role of mitochondria in steroidogenesis.
Adrenal gonadal, placental and brain mitochondria contain several steroidogenic enzymes, notably the cholesterol side chain… Expand
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Highly Cited
2010
Highly Cited
2010
Cellular cholesterol delivery, intracellular processing and utilization for biosynthesis of steroid hormones
Steroid hormones regulate diverse physiological functions such as reproduction, blood salt balance, maintenance of secondary… Expand
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Highly Cited
2004
Highly Cited
2004
Adult male rat hippocampus synthesizes estradiol from pregnenolone by cytochromes P45017alpha and P450 aromatase localized in neurons.
In adult mammalian brain, occurrence of the synthesis of estradiol from endogenous cholesterol has been doubted because of the… Expand
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Highly Cited
2001
Highly Cited
2001
Aromatase (Cyp19) expression is up-regulated by targeted disruption of Dax1.
DAX-1 [dosage-sensitive sex reversal, adrenal hypoplasia congenita (AHC) critical region on the X chromosome, gene 1] is an… Expand
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Highly Cited
2001
Highly Cited
2001
Heterozygous mutation in the cholesterol side chain cleavage enzyme (p450scc) gene in a patient with 46,XY sex reversal and adrenal insufficiency.
Cytochrome P450scc, the mitochondrial cholesterol side chain cleavage enzyme, is the only enzyme that catalyzes the conversion of… Expand
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Highly Cited
1999
Highly Cited
1999
Thirty-seven candidate genes for polycystic ovary syndrome: strongest evidence for linkage is with follistatin.
Polycystic ovary syndrome (PCOS) is a common endocrine disorder of women, characterized by hyperandrogenism and chronic… Expand
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Highly Cited
1998
Highly Cited
1998
Cytochrome P450 side-chain cleavage enzyme in the cerebellar Purkinje neuron and its neonatal change in rats.
Neurosteroids are de novo synthesized in the nervous system through mechanisms at least partly independent of peripheral… Expand
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Highly Cited
1997
Highly Cited
1997
Association of the steroid synthesis gene CYP11a with polycystic ovary syndrome and hyperandrogenism.
Biochemical data implicate an underlying disorder of androgen biosynthesis and/or metabolism in the aetiology of polycystic ovary… Expand
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Highly Cited
1991
Highly Cited
1991
Tumor necrosis factor as a potent inhibitor of adrenocorticotropin-induced cortisol production and steroidogenic P450 enzyme gene expression in cultured human fetal adrenal cells.
We have previously demonstrated that tumor necrosis factor alpha (TNF-alpha), a multifunctional cytokine mainly produced by… Expand
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Highly Cited
1987
Highly Cited
1987
Cytochrome P450c17 (steroid 17 alpha-hydroxylase/17,20 lyase): cloning of human adrenal and testis cDNAs indicates the same gene is expressed in both tissues.
P450c17 is the single enzyme mediating both 17 alpha-hydroxylase (steroid 17 alpha-monooxygenase, EC 1.14.99.9) and 17,20 lyase… Expand
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