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Cytochrome P450 CYP1B1 determines susceptibility to 7, 12-dimethylbenz[a]anthracene-induced lymphomas.
- J. Buters, S. Sakai, F. Gonzalez
- Biology, MedicineProceedings of the National Academy of Sciences…
- 2 March 1999
CYP1B1-null mice, created by targeted gene disruption in embryonic stem cells, were born at the expected frequency from heterozygous matings with no observable phenotype, thus establishing that…
Fungal Cytochrome P450 Monooxygenases: Their Distribution, Structure, Functions, Family Expansion, and Evolutionary Origin
- Wanping Chen, Mi-Kyung Lee, C. Jefcoate, Sun-Chang Kim, Fusheng Chen, Jae-Hyuk Yu
- BiologyGenome biology and evolution
- 25 June 2014
The comparison of fungal CYPomes suggests that generally fungi possess abundant CYPs belonging to a variety of families with the two global families CYP51 and CYP61, indicating individuation of CYPome during the evolution of fungi.
Measurement of substrate and inhibitor binding to microsomal cytochrome P-450 by optical-difference spectroscopy.
- C. Jefcoate
- Biology, ChemistryMethods in enzymology
Mitochondrial Processing of Newly Synthesized Steroidogenic Acute Regulatory Protein (StAR), but Not Total StAR, Mediates Cholesterol Transfer to Cytochrome P450 Side Chain Cleavage Enzyme in Adrenal…
- I. Artemenko, Dong Zhao, D. Hales, K. Hales, C. Jefcoate
- BiologyThe Journal of Biological Chemistry
- 7 December 2001
The present study of the activation of cholesterol metabolism by bromo-cAMP in adrenal cells in relation to35S-StAR turnover indicates that targeting of pp30 to the inner membrane provides the dominant cholesterol transport mechanism.
Characterization of CYP1B1 and CYP1A1 expression in human mammary epithelial cells: role of the aryl hydrocarbon receptor in polycyclic aromatic hydrocarbon metabolism.
- M. Larsen, W. G. Angus, P. Brake, S. Eltom, K. A. Sukow, C. Jefcoate
- Biology, ChemistryCancer research
- 1 June 1998
CYP1B1 is an important activator of polycyclic aromatic hydrocarbons in the mammary gland when environmental chemical exposures minimally induce CYP1A1, indicating a potential risk factor of mammary carcinogenesis through enhanced polycyclIC aromatic hydrocarbon bioactivation.
High-flux mitochondrial cholesterol trafficking, a specialized function of the adrenal cortex.
- C. Jefcoate
- BiologyThe Journal of clinical investigation
- 1 October 2002
The often confusing literature on StAR’s mechanism of action is examined, particularly in light of recent work establishing the importance of other players, and a model for StAR's interaction with cholesterol and with some of these other proteins is presented.
Tissue-specific synthesis and oxidative metabolism of estrogens.
Evidence in support of the role of P4501B1 as the 4-hydroxylase expressed in human breast tissue is reviewed and the hypothesis that sufficient E2 may be present in tissue for formation of catechol metabolites that are estrogenic and which form genotoxic species at levels that may contribute to estrogen carcinogenesis is questioned.
Cyp1b1 Mediates Periostin Regulation of Trabecular Meshwork Development by Suppression of Oxidative Stress
Increased diurnal intraocular pressure (IOP) in Cyp1b1-deficient mice is shown and metabolic activity of CYP1B1 contributes to oxidative homeostasis and ultrastructural organization and function of TM tissue through modulation of Postn expression.
Regulation of cholesterol movement to mitochondrial cytochrome P450scc in steroid hormone synthesis
Aryl-hydrocarbon receptor is an inhibitory regulator of lipid synthesis and of commitment to adipogenesis.
- D. L. Alexander, L. G. Ganem, P. Fernández-Salguero, F. Gonzalez, C. Jefcoate
- BiologyJournal of cell science
- 15 November 1998
Findings implicate the AhR as a constitutive inhibitor of triglyceride synthesis, and as an early regulator of adipocyte differentiation, in primary mouse embryo fibroblasts and spontaneously immortalized MEFs.