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Effects of chloroquine on viral infections: an old drug against today's diseases
- A. Savarino, J. Boelaert, A. Cassone, G. Majori, R. Cauda
- The Lancet Infectious Diseases
- 23 October 2003
Summary Chloroquine is a 9-aminoquinoline known since 1934. Apart from its well-known antimalarial effects, the drug has interesting biochemical properties that might be applied against some… Expand
Crucial Role of the Amino-Terminal Tyrosine Residue 42 and the Carboxyl-Terminal PEST Domain of IκBα in NF-κB Activation by an Oxidative Stress1
- S. Schoonbroodt, V. Ferreira, +4 authors J. Piette
- Biology, Medicine
- The Journal of Immunology
- 15 April 2000
Activation of transcription factor NF-κB involves the signal-dependent degradation of basally phosphorylated inhibitors such as IκBα. In response to proinflammatory cytokines or mitogens, the… Expand
Linezolid-induced inhibition of mitochondrial protein synthesis.
- A. D. De Vriese, R. Coster, +8 authors J. Boelaert
- Medicine, Biology
- Clinical infectious diseases : an official…
- 15 April 2006
BACKGROUND Linezolid is an oxazolidinone antibiotic that is increasingly used to treat drug-resistant, gram-positive pathogens. The mechanism of action is inhibition of bacterial protein synthesis.… Expand
Mucormycosis during deferoxamine therapy is a siderophore-mediated infection. In vitro and in vivo animal studies.
- J. Boelaert, M. de Locht, +5 authors Y. Schneider
- Biology, Medicine
- The Journal of clinical investigation
- 1 May 1993
This study investigates the pathophysiology of mucormycosis caused by Rhizopus, which has been reported in 46 dialysis patients, while treated with deferoxamine (DFO). This drug aggravates… Expand
Anti-HIV effects of chloroquine: mechanisms of inhibition and spectrum of activity
ObjectiveTo investigate the mechanisms and spectrum of the anti-HIV activity of chloroquine. Design and methodsMT-4 cells or peripheral blood mononuclear cells were infected with X4, R5 or R5/X4… Expand
Altered iron metabolism in HIV infection: mechanisms, possible consequences, and proposals for management.
The progression of human immunodeficiency virus (HIV) infection toward its more advanced stages is accompanied by increasing body iron stores. Iron accumulates in macrophages, microglia, endothelial… Expand
Anti-HIV Effects of Chloroquine: Inhibition of Viral Particle Glycosylation and Synergism With Protease Inhibitors
- A. Savarino, M. B. Lucia, +8 authors R. Cauda
- Biology, Medicine
- Journal of acquired immune deficiency syndromes
- 1 March 2004
ObjectiveWe tested the effects of chloroquine (CQ) on glycosylation of HIV particles and in combination with protease inhibitors (PIs) on HIV replication and on P-glycoprotein (P-gp)/multidrug… Expand
Rhizoferrin — a novel siderophore from the fungusRhizopus microsporus var.rhizopodiformis
- H. Drechsel, J. Metzger, S. Freund, G. Jung, J. Boelaert, G. Winkelmann
- Biology of Metals
- 1 December 1991
SummaryFrom a strain ofRhizopus microsporus var.rhizopodiformis a novel siderophore, named rhizoferrin, was isolated by ion-exchange column chromatography, gel filtration and preparative HPLC.… Expand
Staphylococcus aureus infections in hemodialysis: what a nephrologist should know.
- S. Vandecasteele, J. Boelaert, A. D. De Vriese
- Clinical journal of the American Society of…
- 1 August 2009
Staphylococcus aureus is a formidable pathogen that has the ability to colonize approximately half the dialysis population without any sign of disease but is also capable of causing wound and tissue… Expand
The anti-HIV-1 activity of chloroquine.
- A. Savarino, L. Gennero, K. Sperber, J. Boelaert
- Journal of clinical virology : the official…
- 1 February 2001
BACKGROUND there is a dramatic need for drugs with anti-HIV-1 activity that are affordable for resource-poor countries. Chloroquine (CQ) is one such drug. OBJECTIVES to review the data indicating… Expand