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Effects of chloroquine on viral infections: an old drug against today's diseases
Summary Chloroquine is a 9-aminoquinoline known since 1934. Apart from its well-known antimalarial effects, the drug has interesting biochemical properties that might be applied against someExpand
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Crucial Role of the Amino-Terminal Tyrosine Residue 42 and the Carboxyl-Terminal PEST Domain of IκBα in NF-κB Activation by an Oxidative Stress1
Activation of transcription factor NF-κB involves the signal-dependent degradation of basally phosphorylated inhibitors such as IκBα. In response to proinflammatory cytokines or mitogens, theExpand
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Linezolid-induced inhibition of mitochondrial protein synthesis.
BACKGROUND Linezolid is an oxazolidinone antibiotic that is increasingly used to treat drug-resistant, gram-positive pathogens. The mechanism of action is inhibition of bacterial protein synthesis.Expand
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Mucormycosis during deferoxamine therapy is a siderophore-mediated infection. In vitro and in vivo animal studies.
This study investigates the pathophysiology of mucormycosis caused by Rhizopus, which has been reported in 46 dialysis patients, while treated with deferoxamine (DFO). This drug aggravatesExpand
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Anti-HIV effects of chloroquine: mechanisms of inhibition and spectrum of activity
ObjectiveTo investigate the mechanisms and spectrum of the anti-HIV activity of chloroquine. Design and methodsMT-4 cells or peripheral blood mononuclear cells were infected with X4, R5 or R5/X4Expand
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Altered iron metabolism in HIV infection: mechanisms, possible consequences, and proposals for management.
The progression of human immunodeficiency virus (HIV) infection toward its more advanced stages is accompanied by increasing body iron stores. Iron accumulates in macrophages, microglia, endothelialExpand
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Anti-HIV Effects of Chloroquine: Inhibition of Viral Particle Glycosylation and Synergism With Protease Inhibitors
ObjectiveWe tested the effects of chloroquine (CQ) on glycosylation of HIV particles and in combination with protease inhibitors (PIs) on HIV replication and on P-glycoprotein (P-gp)/multidrugExpand
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Rhizoferrin — a novel siderophore from the fungusRhizopus microsporus var.rhizopodiformis
SummaryFrom a strain ofRhizopus microsporus var.rhizopodiformis a novel siderophore, named rhizoferrin, was isolated by ion-exchange column chromatography, gel filtration and preparative HPLC.Expand
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Staphylococcus aureus infections in hemodialysis: what a nephrologist should know.
Staphylococcus aureus is a formidable pathogen that has the ability to colonize approximately half the dialysis population without any sign of disease but is also capable of causing wound and tissueExpand
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The anti-HIV-1 activity of chloroquine.
BACKGROUND there is a dramatic need for drugs with anti-HIV-1 activity that are affordable for resource-poor countries. Chloroquine (CQ) is one such drug. OBJECTIVES to review the data indicatingExpand
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