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Targeted Disruption of the Nuclear Receptor FXR/BAR Impairs Bile Acid and Lipid Homeostasis
It is shown that in allylic hydroxyl ations (catalyzed by either model metalloporphyrins or cytochrome P450) rehydridization could occur to yield multiple products.
Mitochondrial Autophagy Is an HIF-1-dependent Adaptive Metabolic Response to Hypoxia*
This study demonstrates that mitochondrial autophagy is induced by hypoxia, that this process requires the Hypoxia-dependent factor-1-dependent expression of BNIP3 and the constitutive expression of Beclin-1 and Atg5, and that in cells subjected to prolonged hypoxIA, mitochondrial autphagy is an adaptive metabolic response which is necessary to prevent increased levels of reactive oxygen species and cell death.
Hepatocyte Nuclear Factor 4α (Nuclear Receptor 2A1) Is Essential for Maintenance of Hepatic Gene Expression and Lipid Homeostasis
- G. Hayhurst, Ying‐Hue Lee, G. Lambert, J. Ward, F. Gonzalez
- Biology, MedicineMolecular and Cellular Biology
- 15 February 2001
Mice lacking hepatic HNF4α expression accumulated lipid in the liver and exhibited greatly reduced serum cholesterol and triglyceride levels and increased serum bile acid concentrations, indicating that this factor is central to the maintenance of hepatocyte differentiation and is a major in vivo regulator of genes involved in the control of lipid homeostasis.
Role of Aryl Hydrocarbon Receptor-mediated Induction of the CYP1 Enzymes in Environmental Toxicity and Cancer*
- D. Nebert, T. Dalton, A. Okey, F. Gonzalez
- Biology, ChemistryJournal of Biological Chemistry
- 4 June 2004
Differences in AHR affinity between inbred mouse strains reflect variations in CYP1 inducibility and clearly have been shown to be associated with differences in risk of toxicity or cancer caused by PAHs and arylamines.
The orphan nuclear receptor HNF4α determines PXR- and CAR-mediated xenobiotic induction of CYP3A4
It is shown that the orphan nuclear receptor hepatocyte nuclear factor-4α (HNF4α; HNF4A) is critically involved in the PXR- and CAR-mediated transcriptional activation of CYP3A4, an important regulator of coordinate nuclear-receptor–mediated response to xenobiotics.
Targeted disruption of the alpha isoform of the peroxisome proliferator-activated receptor gene in mice results in abolishment of the pleiotropic effects of peroxisome proliferators
It is demonstrated that mPPAR alpha is the major isoform required for mediating the pleiotropic response resulting from the actions of peroxisome proliferators.
The T/ebp null mouse: thyroid-specific enhancer-binding protein is essential for the organogenesis of the thyroid, lung, ventral forebrain, and pituitary.
In situ hybridization showed that the T/ebp gene is expressed in the normal thyroid, lung bronchial epithelium, and specific areas of the forebrain during early embryogenesis, establishing that the expression of T/EBP, a transcription factor known to control thyroid-specific gene transcription, is also essential for organogenesis of the thyroid, lungs, ventral forebrain, and pituitary.
Activation of the nuclear receptor FXR improves hyperglycemia and hyperlipidemia in diabetic mice.
- Yanqiao Zhang, F. Lee, P. Edwards
- Biology, ChemistryProceedings of the National Academy of Sciences…
- 24 January 2006
It is proposed that FXR agonists are promising therapeutic agents for treatment of diabetes mellitus because of their central roles in coordinating regulation of both glucose and lipid metabolism.
Characterization of the Fasting-induced Adipose Factor FIAF, a Novel Peroxisome Proliferator-activated Receptor Target Gene*
- S. Kersten, S. Mandard, W. Wahli
- Biology, Computer ScienceThe Journal of Biological Chemistry
- 15 September 2000
The data suggest that FIAF represents a novel endocrine signal involved in the regulation of metabolism, especially under fasting conditions, and is strongly up-regulated by fasting in white adipose tissue and liver.