Skip to search formSkip to main contentSkip to account menu

Cytochrome P-450 CYP2D6

Known as: Debrisoquine Hydroxylase, Cytochrome P 450 CYP2D6, P450 2D6, Cytochrome 
A cytochrome P450 enzyme that catalyzes the hydroxylation of many drugs and environmental chemicals, such as DEBRISOQUINE; ADRENERGIC RECEPTOR… 
National Institutes of Health

Related topics

Related topics

27 relations
AromataseCYP19A1 protein, humanCYP2C18 protein, humanCYP2C19 gene

Broader (4)

Aryl Hydrocarbon HydroxylasesCytochrome P450Mixed Function OxygenasesXenobiotic Monooxygenases

Narrower (1)

Cytochrome P450 2D6, human

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2003
Highly Cited
2003
Pharmacogenomics as an aspect of molecular autopsy for forensic pathology/toxicology: does genotyping CYP 2D6 serve as an adjunct for certifying methadone toxicity?
Pharmacogenomics, applied as an aspect of molecular autopsy, may be used as an adjunct for certifying methadone fatalities… 
2001
2001
Diversity in Mechanisms of Substrate Oxidation by Cytochrome P450 2D6
Cytochrome P450 (P450) 2D6 was first identified as the polymorphic human debrisoquine hydroxylase and subsequently shown to… 
Highly Cited
1998
Highly Cited
1998
Determinants of the substrate specificity of human cytochrome P-450 CYP2D6: design and construction of a mutant with testosterone hydroxylase activity.
Cytochrome P-450 CYP2D6, human debrisoquine hydroxylase, metabolizes more than 30 prescribed drugs, the vast majority of which… 
1998
1998
Lack of association between human longevity and genetic polymorphisms in drug-metabolizing enzymes at the NAT2, GSTM1 and CYP2D6 loci
Abstract In the present study, the possible role of genetic polymorphism of three drug-metabolizing enzymes, debrisoquine… 
1996
1996
Debrisoquine hydroxylase gene polymorphism frequencies in patients with amyotrophic lateral sclerosis
1995
1995
Human CYP2D6 gene polymorphism in Slovene cancer patients and healthy controls.
The polymorphic CYP2D6 gene encoding debrisoquine hydroxylase has attracted much interest for its possible role in human… 
1992
1992
Metabolic cytochrome P450 genotypes and assessment of individual susceptibility to lung cancer.
Three polymorphic cytochrome P450 genes that have attracted interest for their potential role in human pulmonary carcinogenesis… 
1991
1991
Concordance of P450 2D6 (debrisoquine hydroxylase) phenotype and genotype: inability of dextromethorphan metabolic ratio to discriminate reliably heterozygous and homozygous extensive metabolizers.
Debrisoquine-hydroxylase (P450 2D6) not equal to phenotype was determined in 116 individuals using dextromethorphan as the… 
1986
1986
Oxidation of tricyclic antidepressant drugs, debrisoquine and 7-ethoxyresorufin, by human liver preparations.
Data obtained from human studies in vivo show that the dispositions of the tricyclic antidepressant drugs desmethylimipramine… 
1984
1984
A human cytochrome P-450 characterized by inhibition studies as the sparteine-debrisoquine monooxygenase.
The present study compares the debrisoquine monooxygenase and the sparteine monooxygenase activities of human liver microsomes… 
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)