Cytochrome P-450 CYP2D6

Known as: Debrisoquine Hydroxylase, Cytochrome P 450 CYP2D6, P450 2D6, Cytochrome 
A cytochrome P450 enzyme that catalyzes the hydroxylation of many drugs and environmental chemicals, such as DEBRISOQUINE; ADRENERGIC RECEPTOR… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1976-2018
0102019762018

Related topics

Related topics

27 relations
AromataseCYP19A1 protein, humanCYP2C18 protein, humanCYP2C19 gene
(More)

Broader (4)

Aryl Hydrocarbon HydroxylasesCytochrome P450Mixed Function OxygenasesXenobiotic Monooxygenases

Narrower (1)

Cytochrome P450 2D6, human

Related mentions per year

Related mentions per year

1936-2019
19401960198020002020
Cytochrome P-450 CYP2D6
standards characteristics
physiological aspects
Mixed Function Oxygenases
Cytochrome P450
Cytochrome P-450 CYP1A1

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
1999
1999
Correlation between cytochrome P-450 CYP2D6 (CYP2D6) genotype and phenotype.
AIM To study the correlation between CYP2D6 genotype and its phenotype. METHODS CYP2D6 genotyping was made by detecting CYP2D6… (More)
Is this relevant?
1998
1998
Determinants of the substrate specificity of human cytochrome P-450 CYP2D6: design and construction of a mutant with testosterone hydroxylase activity.
Cytochrome P-450 CYP2D6, human debrisoquine hydroxylase, metabolizes more than 30 prescribed drugs, the vast majority of which… (More)
Is this relevant?
Highly Cited
1996
Highly Cited
1996
Frequent distribution of ultrarapid metabolizers of debrisoquine in an ethiopian population carrying duplicated and multiduplicated functional CYP2D6 alleles.
The debrisoquine hydroxylase (CYP2D6) catalyzes the oxidative metabolism of more than 40 different clinically important drugs… (More)
Is this relevant?
Highly Cited
1996
Highly Cited
1996
Hepatic biotransformation of docetaxel (Taxotere) in vitro: involvement of the CYP3A subfamily in humans.
Docetaxel metabolism mediated by cytochrome P450-dependent monooxygenases was evaluated in human liver microsomes and hepatocytes… (More)
  • figure I
  • figure 2
  • table I
  • figure 3
  • figure 4
Is this relevant?
Highly Cited
1996
Highly Cited
1996
A novel mutant variant of the CYP2D6 gene (CYP2D6*17) common in a black African population: association with diminished debrisoquine hydroxylase activity.
1. The debrisoquine hydroxylase (CYP2D6) is polymorphically distributed. Not only are there differences in the proportions of… (More)
  • table 1
  • figure 1
  • table 2
  • figure 2
  • table 3
Is this relevant?
Highly Cited
1995
Highly Cited
1995
The hyperthermic and neurotoxic effects of 'Ecstasy' (MDMA) and 3,4 methylenedioxyamphetamine (MDA) in the Dark Agouti (DA) rat, a model of the CYP2D6 poor metabolizer phenotype.
1. The effect of administration of 3,4-methylenedioxymethamphetamine (MDMA or 'Ecstasy') and its N-demethylated product, 3,4… (More)
Is this relevant?
Highly Cited
1994
Highly Cited
1994
The demethylenation of methylenedioxymethamphetamine ("ecstasy") by debrisoquine hydroxylase (CYP2D6).
The metabolism of methylenedioxymethamphetamine (MDMA, "ecstasy") was examined in a microsomal preparation of the yeast… (More)
Is this relevant?
Highly Cited
1989
Highly Cited
1989
The human debrisoquine 4-hydroxylase (CYP2D) locus: sequence and identification of the polymorphic CYP2D6 gene, a related gene, and a pseudogene.
The debrisoquine-4-hydroxylase polymorphism is a genetic variation in oxidative drug metabolism characterized by two phenotypes… (More)
  • figure I
  • figure 3
  • table I
  • figure 4
  • table 2
Is this relevant?
Highly Cited
1987
Highly Cited
1987
High-performance liquid chromatographic assays for bufuralol 1'-hydroxylase, debrisoquine 4-hydroxylase, and dextromethorphan O-demethylase in microsomes and purified cytochrome P-450 isozymes of…
Bufuralol, debrisoquine, and dextromethorphan are three prototype substrates of the common genetic deficiency of oxidative drug… (More)
Is this relevant?
1985
1985
In vitro inhibition studies of two isozymes of human liver cytochrome P-450. Mephenytoin p-hydroxylase and sparteine monooxygenase.
Human liver preparations were used to screen various drugs for their capability of binding to mephenytoin p-hydroxylase and… (More)
Is this relevant?