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Cytochrome P-450 CYP2D6
Known as:
Debrisoquine Hydroxylase
, Cytochrome P 450 CYP2D6
, P450 2D6, Cytochrome
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A cytochrome P450 enzyme that catalyzes the hydroxylation of many drugs and environmental chemicals, such as DEBRISOQUINE; ADRENERGIC RECEPTOR…
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National Institutes of Health
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Related topics
Related topics
27 relations
Aromatase
CYP19A1 protein, human
CYP2C18 protein, human
CYP2C19 gene
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Broader (4)
Aryl Hydrocarbon Hydroxylases
Cytochrome P450
Mixed Function Oxygenases
Xenobiotic Monooxygenases
Narrower (1)
Cytochrome P450 2D6, human
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2003
Highly Cited
2003
A novel mutant variant of the CYP2D6 gene (CYP2D6*17) common in a black African population: association with diminished debrisoquine hydroxylase activity.
C. Masimirembwa
,
I. Persson
,
L. Bertilsson
,
J. Hasler
,
M. Ingelman-Sundberg
British Journal of Clinical Pharmacology
2003
Corpus ID: 37312572
1. The debrisoquine hydroxylase (CYP2D6) is polymorphically distributed. Not only are there differences in the proportions of…
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Review
1996
Review
1996
Genetic metabolic polymorphisms and the risk of cancer: a review of the literature.
A. d’Errico
,
E. Taioli
,
X. Chen
,
P. Vineis
Biomarkers
1996
Corpus ID: 9142792
Abstract The purpose of this paper is to systematically analyse the design and results of epidemiological studies on the…
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Review
1996
Review
1996
Human drug-metabolizing enzyme polymorphisms: effects on risk of toxicity and cancer.
D. Nebert
,
R. McKinnon
,
A. Puga
DNA and Cell Biology
1996
Corpus ID: 23543601
A growing number of human genetic polymorphisms in drug-metabolizing enzymes (DMEs) are being characterized. Some of these have…
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Highly Cited
1996
Highly Cited
1996
Frequent distribution of ultrarapid metabolizers of debrisoquine in an ethiopian population carrying duplicated and multiduplicated functional CYP2D6 alleles.
E. Aklillu
,
I. Persson
,
L. Bertilsson
,
I. Johansson
,
F. Rodrigues
,
M. Ingelman-Sundberg
Journal of Pharmacology and Experimental…
1996
Corpus ID: 19077408
The debrisoquine hydroxylase (CYP2D6) catalyzes the oxidative metabolism of more than 40 different clinically important drugs…
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Highly Cited
1996
Highly Cited
1996
Hepatic biotransformation of docetaxel (Taxotere) in vitro: involvement of the CYP3A subfamily in humans.
F. Marre
,
G. Sanderink
,
G. de Sousa
,
C. Gaillard
,
M. Martinet
,
R. Rahmani
Cancer Research
1996
Corpus ID: 7828546
Docetaxel metabolism mediated by cytochrome P450-dependent monooxygenases was evaluated in human liver microsomes and hepatocytes…
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Highly Cited
1994
Highly Cited
1994
The demethylenation of methylenedioxymethamphetamine ("ecstasy") by debrisoquine hydroxylase (CYP2D6).
G. Tucker
,
M. Lennard
,
+6 authors
T. Chu
Biochemical Pharmacology
1994
Corpus ID: 37971194
Highly Cited
1990
Highly Cited
1990
Identification of the primary gene defect at the cytochrome P450 CYP2D locus
A. Gough
,
J. S. Miles
,
+4 authors
C. Wolf
Nature
1990
Corpus ID: 4311146
THE mammalian cytochrome P450-dependent monooxygenase system is involved in the metabolism of drugs and chemical carcinogens1–5…
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Highly Cited
1990
Highly Cited
1990
The dopamine transporter and cytochrome P45OIID1 (debrisoquine 4-hydroxylase) in brain: resolution and identification of two distinct [3H]GBR-12935 binding proteins.
H. Niznik
,
R. Tyndale
,
+4 authors
W. Kalow
Archives of Biochemistry and Biophysics
1990
Corpus ID: 43710256
Highly Cited
1989
Highly Cited
1989
The human debrisoquine 4-hydroxylase (CYP2D) locus: sequence and identification of the polymorphic CYP2D6 gene, a related gene, and a pseudogene.
S. Kimura
,
M. Umeno
,
R. Skoda
,
U. Meyer
,
F. Gonzalez
American Journal of Human Genetics
1989
Corpus ID: 25077007
The debrisoquine-4-hydroxylase polymorphism is a genetic variation in oxidative drug metabolism characterized by two phenotypes…
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Highly Cited
1984
Highly Cited
1984
Mephenytoin hydroxylation deficiency in Caucasians: Frequency of a new oxidative drug metabolism polymorphism
P. Wedlund
,
W. S. Aslanian
,
C. Mcallister
,
G. Wilkinson
,
R. Branch
Clinical pharmacology and therapy
1984
Corpus ID: 22765038
The ability of normal subjects to hydroxylate mephenytoin (100 mg) or debrisoquine (10 mg) after oral dosing was investigated in…
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