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Cytochrome P-450 CYP2D6

Known as: Debrisoquine Hydroxylase, Cytochrome P 450 CYP2D6, P450 2D6, Cytochrome 
A cytochrome P450 enzyme that catalyzes the hydroxylation of many drugs and environmental chemicals, such as DEBRISOQUINE; ADRENERGIC RECEPTOR… Expand
National Institutes of Health

Related topics

Related topics

27 relations
AromataseCYP19A1 protein, humanCYP2C18 protein, humanCYP2C19 gene
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Broader (4)

Aryl Hydrocarbon HydroxylasesCytochrome P450Mixed Function OxygenasesXenobiotic Monooxygenases

Narrower (1)

Cytochrome P450 2D6, human

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2003
Highly Cited
2003
Polymorphisms in the CYP 2D6 Gene: Association with Plasma Concentrations of Fluoxetine and Paroxetine
Most antidepressants are metabolized by cytochrome P450 (CYP) 2D6, and it is well known that there may be significant… Expand
Highly Cited
1996
Highly Cited
1996
Frequent distribution of ultrarapid metabolizers of debrisoquine in an ethiopian population carrying duplicated and multiduplicated functional CYP2D6 alleles.
The debrisoquine hydroxylase (CYP2D6) catalyzes the oxidative metabolism of more than 40 different clinically important drugs… Expand
Highly Cited
1996
Highly Cited
1996
Hepatic biotransformation of docetaxel (Taxotere) in vitro: involvement of the CYP3A subfamily in humans.
Docetaxel metabolism mediated by cytochrome P450-dependent monooxygenases was evaluated in human liver microsomes and hepatocytes… Expand
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Highly Cited
1996
Highly Cited
1996
A novel mutant variant of the CYP2D6 gene (CYP2D6*17) common in a black African population: association with diminished debrisoquine hydroxylase activity.
1. The debrisoquine hydroxylase (CYP2D6) is polymorphically distributed. Not only are there differences in the proportions of… Expand
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Highly Cited
1994
Highly Cited
1994
The demethylenation of methylenedioxymethamphetamine ("ecstasy") by debrisoquine hydroxylase (CYP2D6).
The metabolism of methylenedioxymethamphetamine (MDMA, "ecstasy") was examined in a microsomal preparation of the yeast… Expand
Highly Cited
1990
Highly Cited
1990
Identification of the primary gene defect at the cytochrome P450 CYP2D locus
THE mammalian cytochrome P450-dependent monooxygenase system is involved in the metabolism of drugs and chemical carcinogens1–5… Expand
Highly Cited
1990
Highly Cited
1990
The dopamine transporter and cytochrome P45OIID1 (debrisoquine 4-hydroxylase) in brain: resolution and identification of two distinct [3H]GBR-12935 binding proteins.
Two [3H]GBR-12935 binding proteins, identified as the dopamine transporter and cytochrome P45OIID1, were solubilized in digitonin… Expand
Highly Cited
1989
Highly Cited
1989
The human debrisoquine 4-hydroxylase (CYP2D) locus: sequence and identification of the polymorphic CYP2D6 gene, a related gene, and a pseudogene.
The debrisoquine-4-hydroxylase polymorphism is a genetic variation in oxidative drug metabolism characterized by two phenotypes… Expand
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Highly Cited
1985
Highly Cited
1985
Inhibition of desmethylimipramine 2-hydroxylation by drugs in human liver microsomes.
The 2-hydroxylation of desmethylimipramine (DMI) correlates strongly with the 4-hydroxylation of debrisoquine (D) both in human… Expand
Highly Cited
1984
Highly Cited
1984
Mephenytoin hydroxylation deficiency in Caucasians: Frequency of a new oxidative drug metabolism polymorphism
The ability of normal subjects to hydroxylate mephenytoin (100 mg) or debrisoquine (10 mg) after oral dosing was investigated in… Expand
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