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Cytochrome P-450 CYP2D6

Known as: Debrisoquine Hydroxylase, Cytochrome P 450 CYP2D6, P450 2D6, Cytochrome 
A cytochrome P450 enzyme that catalyzes the hydroxylation of many drugs and environmental chemicals, such as DEBRISOQUINE; ADRENERGIC RECEPTOR… Expand
National Institutes of Health

Papers overview

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Highly Cited
2003
Highly Cited
2003
Most antidepressants are metabolized by cytochrome P450 (CYP) 2D6, and it is well known that there may be significant… Expand
Highly Cited
1996
Highly Cited
1996
The debrisoquine hydroxylase (CYP2D6) catalyzes the oxidative metabolism of more than 40 different clinically important drugs… Expand
Highly Cited
1996
Highly Cited
1996
Docetaxel metabolism mediated by cytochrome P450-dependent monooxygenases was evaluated in human liver microsomes and hepatocytes… Expand
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Highly Cited
1996
Highly Cited
1996
1. The debrisoquine hydroxylase (CYP2D6) is polymorphically distributed. Not only are there differences in the proportions of… Expand
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Highly Cited
1994
Highly Cited
1994
The metabolism of methylenedioxymethamphetamine (MDMA, "ecstasy") was examined in a microsomal preparation of the yeast… Expand
Highly Cited
1990
Highly Cited
1990
THE mammalian cytochrome P450-dependent monooxygenase system is involved in the metabolism of drugs and chemical carcinogens1–5… Expand
Highly Cited
1990
Highly Cited
1990
Two [3H]GBR-12935 binding proteins, identified as the dopamine transporter and cytochrome P45OIID1, were solubilized in digitonin… Expand
Highly Cited
1989
Highly Cited
1989
The debrisoquine-4-hydroxylase polymorphism is a genetic variation in oxidative drug metabolism characterized by two phenotypes… Expand
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Highly Cited
1985
Highly Cited
1985
The 2-hydroxylation of desmethylimipramine (DMI) correlates strongly with the 4-hydroxylation of debrisoquine (D) both in human… Expand
Highly Cited
1984
Highly Cited
1984
The ability of normal subjects to hydroxylate mephenytoin (100 mg) or debrisoquine (10 mg) after oral dosing was investigated in… Expand