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Cytochrome P-450 CYP2D6

Known as: Debrisoquine Hydroxylase, Cytochrome P 450 CYP2D6, P450 2D6, Cytochrome 
A cytochrome P450 enzyme that catalyzes the hydroxylation of many drugs and environmental chemicals, such as DEBRISOQUINE; ADRENERGIC RECEPTOR… 
National Institutes of Health

Related topics

Related topics

27 relations
AromataseCYP19A1 protein, humanCYP2C18 protein, humanCYP2C19 gene

Broader (4)

Aryl Hydrocarbon HydroxylasesCytochrome P450Mixed Function OxygenasesXenobiotic Monooxygenases

Narrower (1)

Cytochrome P450 2D6, human

Papers overview

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Highly Cited
2003
Highly Cited
2003
Pharmacogenomics as an aspect of molecular autopsy for forensic pathology/toxicology: does genotyping CYP 2D6 serve as an adjunct for certifying methadone toxicity?
Pharmacogenomics, applied as an aspect of molecular autopsy, may be used as an adjunct for certifying methadone fatalities… 
Highly Cited
2002
Highly Cited
2002
Diversity in the oxidation of substrates by cytochrome P450 2D6: lack of an obligatory role of aspartate 301-substrate electrostatic bonding.
Cytochrome P450 (P450) 2D6 was first identified as the polymorphic human debrisoquine hydroxylase and subsequently shown to… 
Highly Cited
2000
Highly Cited
2000
Polymorphisms of the CYP2D6 gene increase susceptibility to ankylosing spondylitis.
Ankylosing spondylitis (AS) is a common and highly familial rheumatic disorder. The sibling recurrence risk ratio for the disease… 
Highly Cited
1998
Highly Cited
1998
Determinants of the substrate specificity of human cytochrome P-450 CYP2D6: design and construction of a mutant with testosterone hydroxylase activity.
Cytochrome P-450 CYP2D6, human debrisoquine hydroxylase, metabolizes more than 30 prescribed drugs, the vast majority of which… 
1996
1996
CYP2D6 mRNA expression in circulating peripheral blood mononuclear cells correlates with in vivo debrisoquine hydroxylase activity in extensive metabolizers.
Extensive metabolizers of drugs which are oxidized by cytochrome P450s show wide interindividual variability in drug metabolism… 
1992
1992
Metabolic cytochrome P450 genotypes and assessment of individual susceptibility to lung cancer.
Three polymorphic cytochrome P450 genes that have attracted interest for their potential role in human pulmonary carcinogenesis… 
Highly Cited
1990
Highly Cited
1990
The dopamine transporter and cytochrome P45OIID1 (debrisoquine 4-hydroxylase) in brain: resolution and identification of two distinct [3H]GBR-12935 binding proteins.
1989
1989
Evidence in humans for variant allozymes of the nondeficient sparteine/debrisoquine monooxygenase (P45OIID 1) in vitro.
Sparteine oxidation is part of a genetic polymorphism that affects the metabolism of many drugs and is under monogenic control… 
Highly Cited
1985
Highly Cited
1985
In vitro inhibition studies of two isozymes of human liver cytochrome P-450. Mephenytoin p-hydroxylase and sparteine monooxygenase.
Human liver preparations were used to screen various drugs for their capability of binding to mephenytoin p-hydroxylase and… 
Highly Cited
1985
Highly Cited
1985
Inhibition of desmethylimipramine 2-hydroxylation by drugs in human liver microsomes.
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