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Cytochrome P-450 CYP2D6

Known as: Debrisoquine Hydroxylase, Cytochrome P 450 CYP2D6, P450 2D6, Cytochrome 
A cytochrome P450 enzyme that catalyzes the hydroxylation of many drugs and environmental chemicals, such as DEBRISOQUINE; ADRENERGIC RECEPTOR… Expand
National Institutes of Health

Papers overview

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Highly Cited
2003
Highly Cited
2003
Most antidepressants are metabolized by cytochrome P450 (CYP) 2D6, and it is well known that there may be significant… Expand
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Highly Cited
1996
Highly Cited
1996
The debrisoquine hydroxylase (CYP2D6) catalyzes the oxidative metabolism of more than 40 different clinically important drugs… Expand
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Highly Cited
1996
Highly Cited
1996
1. The debrisoquine hydroxylase (CYP2D6) is polymorphically distributed. Not only are there differences in the proportions of… Expand
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Highly Cited
1996
Highly Cited
1996
The debrisoquine hydroxylase (CYP2D6), which metabolizes more than 30 different drugs, is highly polymorphic. In subjects having… Expand
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Highly Cited
1996
Highly Cited
1996
Docetaxel metabolism mediated by cytochrome P450-dependent monooxygenases was evaluated in human liver microsomes and hepatocytes… Expand
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Highly Cited
1995
Highly Cited
1995
1. The effect of administration of 3,4-methylenedioxymethamphetamine (MDMA or 'Ecstasy') and its N-demethylated product, 3,4… Expand
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Highly Cited
1994
Highly Cited
1994
The metabolism of methylenedioxymethamphetamine (MDMA, "ecstasy") was examined in a microsomal preparation of the yeast… Expand
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Highly Cited
1990
Highly Cited
1990
THE mammalian cytochrome P450-dependent monooxygenase system is involved in the metabolism of drugs and chemical carcinogens1–5… Expand
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Highly Cited
1990
Highly Cited
1990
Two [3H]GBR-12935 binding proteins, identified as the dopamine transporter and cytochrome P45OIID1, were solubilized in digitonin… Expand
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Highly Cited
1989
Highly Cited
1989
The debrisoquine-4-hydroxylase polymorphism is a genetic variation in oxidative drug metabolism characterized by two phenotypes… Expand
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