Cytochrome P-450 CYP2D6

Known as: Debrisoquine Hydroxylase, Cytochrome P 450 CYP2D6, P450 2D6, Cytochrome 
A cytochrome P450 enzyme that catalyzes the hydroxylation of many drugs and environmental chemicals, such as DEBRISOQUINE; ADRENERGIC RECEPTOR… (More)
National Institutes of Health

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Topic mentions per year

1976-2018
0102019762018

Papers overview

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1999
1999
AIM To study the correlation between CYP2D6 genotype and its phenotype. METHODS CYP2D6 genotyping was made by detecting CYP2D6… (More)
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1998
1998
Cytochrome P-450 CYP2D6, human debrisoquine hydroxylase, metabolizes more than 30 prescribed drugs, the vast majority of which… (More)
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Highly Cited
1996
Highly Cited
1996
The debrisoquine hydroxylase (CYP2D6) catalyzes the oxidative metabolism of more than 40 different clinically important drugs… (More)
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Highly Cited
1996
Highly Cited
1996
Docetaxel metabolism mediated by cytochrome P450-dependent monooxygenases was evaluated in human liver microsomes and hepatocytes… (More)
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Highly Cited
1996
Highly Cited
1996
1. The debrisoquine hydroxylase (CYP2D6) is polymorphically distributed. Not only are there differences in the proportions of… (More)
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Highly Cited
1995
Highly Cited
1995
1. The effect of administration of 3,4-methylenedioxymethamphetamine (MDMA or 'Ecstasy') and its N-demethylated product, 3,4… (More)
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Highly Cited
1994
Highly Cited
1994
The metabolism of methylenedioxymethamphetamine (MDMA, "ecstasy") was examined in a microsomal preparation of the yeast… (More)
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Highly Cited
1989
Highly Cited
1989
The debrisoquine-4-hydroxylase polymorphism is a genetic variation in oxidative drug metabolism characterized by two phenotypes… (More)
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Highly Cited
1987
Highly Cited
1987
Bufuralol, debrisoquine, and dextromethorphan are three prototype substrates of the common genetic deficiency of oxidative drug… (More)
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1985
1985
Human liver preparations were used to screen various drugs for their capability of binding to mephenytoin p-hydroxylase and… (More)
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