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Metabolic gene polymorphism frequencies in control populations.
Using the International Project on Genetic Susceptibility to Environmental Carcinogens (GSEC) database containing information on over 15,000 control (noncancer) subjects, the allele and genotypeExpand
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Characterisation and PCR‐based detection of a CYP2A6 gene deletion found at a high frequency in a Chinese population
Cytochrome P450 2A6 is an important human hepatic P450 which activates pre‐carcinogens, oxidises some drugs and constitutes the major nicotine C‐oxidase. In fact, results have been presented in theExpand
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Association between lung cancer and microsomal epoxide hydrolase genotypes.
Microsomal epoxide hydrolase (mEH) is involved in the metabolism of tobacco-derived carcinogens. Polymorphisms in exons 3 and 4 of the EPHX gene have been reported to be associated with variations inExpand
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Point-mutational MspI and Ile-Val polymorphisms closely linked in the CYP1A1 gene: lack of association with susceptibility to lung cancer in a Finnish study population.
In this study of 87 lung cancer patients, 23 patients with lung disease other than cancer, and 121 healthy controls, no association was found between the MspI restriction fragment length polymorphismExpand
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Molecular epidemiology of sporadic breast cancer. The role of polymorphic genes involved in oestrogen biosynthesis and metabolism.
The major known risk factors for female breast cancer are associated with prolonged exposure to increased levels of oestrogen. The predominant theory relates to effects of oestrogen on cell growth.Expand
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Association of prostate cancer with vitamin D receptor gene polymorphism.
The incidence of prostate cancer in the United States is second only to skin cancers, and the disease kills almost the same number of men as breast cancer does women. Relatively few risk factors areExpand
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Glutathione S-transferase M1, M3, P1, and T1 genetic polymorphisms and susceptibility to breast cancer.
This study was undertaken to examine if glutathione S-transferase (GST) M1, M3, P1, and T1 genotypes affected breast cancer risk in Finnish women. The study population consisted of 483 incidentExpand
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XRCC1 genetic polymorphism and breast cancer risk.
Department of Industrial Hygiene and Toxicology,Finnish Institute of Occupational Health, Helsinki, FinlandCorrespondence to Daehee Kang, MD, PhD, Department of Preventive Medicine,Seoul NationalExpand
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Role of alcohol dehydrogenase 3 and cytochrome P‐4502E1 genotypes in susceptibility to cancers of the upper aerodigestive tract
Alcohol is a recognized risk factor for upper aerodigestive tract (UAT) cancers, but the mechanism by which alcohol causes cancer remains obscure. Ethanol is oxidized to acetaldehyde (the suspectedExpand
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Diagnosis of polymorphisms in carcinogen-activating and inactivating enzymes and cancer susceptibility--a review.
Up to 90% of all cancers are possibly caused by environmental factors, such as tobacco smoke, diet and occupational exposures. The majority of chemical carcinogens require metabolic activation beforeExpand
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