• Publications
  • Influence
The use of caffeine for enzyme assays: A critical appraisal
  • W. Kalow, B. Tang
  • Chemistry, Medicine
  • Clinical pharmacology and therapeutics
  • 1 May 1993
Clinical Pharmacology and Therapeutics (1993) 53, 503–514; doi:10.1038/clpt.1993.63
Cytochrome P-450 hPCN3, a novel cytochrome P-450 IIIA gene product that is differentially expressed in adult human liver. cDNA and deduced amino acid sequence and distinct specificities of
TLDR
HPCN3 is a newly described cytochrome P-450 that is differentially expressed in the adult human population and that has overlapping substrate specificity compared to hPCN1 for metabolism of steroid and drug substrates. Expand
Biotransformation of caffeine, paraxanthine, theobromine and theophylline by cDNA-expressed human CYP1A2 and CYP2E1.
TLDR
The most striking finding was that CYP2E1 (the ethanol-inducible form) had major influences upon caffeine metabolism: in particular, it catalysed the formation of theophylline and theobromine from caffeine. Expand
Intramuscular desferrioxamine in patients with Alzheimer's disease
TLDR
It is concluded that sustained administration of desferrioxamine may slow the clinical progression of the dementia associated with AD. Expand
A METHOD FOR THE DETECTION OF ATYPICAL FORMS OF HUMAN SERUM CHOLINESTERASE. DETERMINATION OF DIBUCAINE NUMBERS
Cases with atypical esterase activity were found by determining esterase inhibition in numerous sera. A suitable inhibitor was the local anaesthetic dibucaine (cinchocaine, TN Nupercaine, Perkain). AExpand
Use of caffeine metabolite ratios to explore CYP1A2 and xanthine oxidase activities
  • W. Kalow, B. Tang
  • Chemistry, Medicine
  • Clinical pharmacology and therapeutics
  • 1 November 1991
TLDR
Caffeine was used as a metabolic probe to screen healthy subjects for their activities of two enzymes, deduced to be CYP1A2 (an inducible cytochrome P450) and xanthine oxidase, and both indexes showed a log normal distribution. Expand
Interactions of amphetamine analogs with human liver CYP2D6.
TLDR
It is suggested that phenylisopropylamines as a class interact with CYP2D6 as substrates and/or inhibitors, and the potential for polymorphic oxidation via CYP 2D6 may be a source of interindividual variation in their abuse liability and toxicity. Expand
Variability in caffeine metabolism
TLDR
Urinary metabolites excreted after oral caffeine were quantified in a healthy sample from the Toronto population by HPLC analyses and it was shown that a ratio providing an index of polymorphic N‐acetyltransferase activity holds promise as a simple marker for acetylator status in man. Expand
cDNA cloning and sequence and cDNA-directed expression of human P450 IIB1: identification of a normal and two variant cDNAs derived from the CYP2B locus on chromosome 19 and differential expression
TLDR
The data suggest either that defective hIIB1 genes exist in humans or that the h IIB1 gene is regulated and variably induced in the authors' liver specimens. Expand
A comparison of optical and manometric methods for the assay of human serum cholinesterase.
A method for the assay of human serum cholinesterase (pseudocholinesterase) is described in detail. The disappearance of benzoylcholine is measured by ultraviolet spectrophotometry. Minute amounts ofExpand
...
1
2
3
4
5
...