• Publications
  • Influence
Metabolism of 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine by Mitochondrion-targeted Cytochrome P450 2D6
Background: Metabolism of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) to toxic MPP+ is critical in chemically induced Parkinson disease. Results: Mitochondrial CYP2D6 supported byExpand
  • 48
  • 4
Epigenetic modification of miR-663 controls mitochondria-to-nucleus retrograde signaling and tumor progression
The normal cellular function requires communication between mitochondria and the nucleus, termed mitochondria-to-nucleus retrograde signaling. Disruption of this mechanism has been implicated in theExpand
  • 23
  • 3
Reversing wrinkled skin and hair loss in mice by restoring mitochondrial function
Mitochondrial DNA (mtDNA) depletion is involved in mtDNA depletion syndromes, mitochondrial diseases, aging and aging-associated chronic diseases, and other human pathologies. To evaluate theExpand
  • 19
  • 1
  • Open Access
Targeting of Splice Variants of Human Cytochrome P450 2C8 (CYP2C8) to Mitochondria and Their Role in Arachidonic Acid Metabolism and Respiratory Dysfunction*
Background: Human CYP2C8 is involved in the metabolism of >20% of drugs on the market. Results: Both full-length (WT) CYP2C8 and splice variant 3 are bimodally targeted to mitochondria. Conclusion:Expand
  • 11
Mitochondrial localization, import, and mitochondrial function of the androgen receptor
Nuclear localization of androgen receptor (AR) directs transcriptional regulation of a host of genes, referred to as genomic signaling. Additionally, nonnuclear or nongenomic activities of the ARExpand
  • 9
PAICS, a Purine Nucleotide Metabolic Enzyme, is Involved in Tumor Growth and the Metastasis of Colorectal Cancer
The identification of colorectal cancer (CRC) molecular targets is needed for the development of drugs that improve patient survival. We investigated the functional role ofExpand
  • 2
  • Open Access
Targeting P4HA1 with a Small Molecule Inhibitor in a Colorectal Cancer PDX Model☆
Deposition, remodeling, and signaling of the extracellular matrix facilitate tumor growth and metastasis. Here, we demonstrated that an enzyme, collagen prolyl 4-hydroxylase, alpha polypeptide IExpand
  • 1
Abstract B42: Polymorphism of CYP3A5 gene in Indian chronic myeloid leukemia patients
Abstracts: Frontiers in Cancer Prevention Research 2008 B42 Objective Chronic myeloid leukemia (CML) is a clonal hematopoetic stem cell disorder characterized by the Philadelphia chromosome.Expand
  • 1