• Publications
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The Yale-Brown Obsessive Compulsive Scale. I. Development, use, and reliability.
The Yale-Brown Obsessive Compulsive Scale was designed to remedy the problems of existing rating scales by providing a specific measure of the severity of symptoms of obsessive-compulsive disorderExpand
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The development of a Clinician-Administered PTSD Scale
Several interviews are available for assessing PTSD. These interviews vary in merit when compared on stringent psychometric and utility standards. Of all the interviews, the Clinician-AdministeredExpand
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The Yale-Brown Obsessive Compulsive Scale. II. Validity.
The development design and reliability of the Yale-Brown Obsessive Compulsive Scale have been described elsewhere. We focused on the validity of the Yale-Brown Scale and its sensitivity to change.Expand
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A randomized trial of an N-methyl-D-aspartate antagonist in treatment-resistant major depression.
CONTEXT Existing therapies for major depression have a lag of onset of action of several weeks, resulting in considerable morbidity. Exploring pharmacological strategies that have rapid onset ofExpand
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Subanesthetic effects of the noncompetitive NMDA antagonist, ketamine, in humans. Psychotomimetic, perceptual, cognitive, and neuroendocrine responses.
BACKGROUND To characterize further behavioral, cognitive, neuroendocrine, and physiological effects of subanesthetic doses of ketamine hydrochloride in healthy human subjects. Ketamine, aExpand
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Measurement of Dissociative States with the Clinician-Administered Dissociative States Scale (CADSS)
The purpose of this study was to develop an instrument for the measurement of present-state dissociative symptoms, the Clinician Administered Dissociative States Scale (CADSS). Reported here areExpand
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Psychobiological mechanisms of resilience and vulnerability: implications for successful adaptation to extreme stress.
  • D. Charney
  • Medicine, Psychology
  • The American journal of psychiatry
  • 1 February 2004
OBJECTIVE Most research on the effects of severe psychological stress has focused on stress-related psychopathology. Here, the author develops psychobiological models of resilience to extreme stress.Expand
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Antidepressant efficacy of ketamine in treatment-resistant major depression: a two-site randomized controlled trial.
OBJECTIVE Ketamine, a glutamate N-methyl-d-aspartate (NMDA) receptor antagonist, has shown rapid antidepressant effects, but small study groups and inadequate control conditions in prior studies haveExpand
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MRI-based measurement of hippocampal volume in patients with combat-related posttraumatic stress disorder.
OBJECTIVE Studies in nonhuman primates suggest that high levels of cortisol associated with stress have neurotoxic effects on the hippocampus, a brain structure involved in memory. The authorsExpand
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