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Low cerebrospinal fluid 5-hydroxyindoleacetic acid concentration differentiates impulsive from nonimpulsive violent behavior.
Of the groups studied, impulsive violent offenders who had attempted suicide had the lowest 5HIAA levels, which may be a marker of impulsivity rather than violence. Expand
μ opioid receptor gene variants: lack of association with alcohol dependence
Data do not support a role of the μ opioid receptor in susceptibility to alcohol dependence, but the potential relationship between OPRM1 genetic variation and response to endogenous opioids and exogenous opiates can now be investigated. Expand
CSF biochemistries, glucose metabolism, and diurnal activity rhythms in alcoholic, violent offenders, fire setters, and healthy volunteers.
A low CSF 5-HIAA concentration was primarily associated with impulsivity and high CSF testosterone concentration, with aggressiveness or interpersonal violence in alcoholic, impulsive and nonimpulsive offenders. Expand
Effects of Acute Tryptophan Depletion on Plasma and Cerebrospinal Fluid Tryptophan and 5‐Hydroxyindoleacetic Acid in Normal Volunteers
Brain serotonin synthesis and metabolism (turnover), as indicated by CSF concentrations of 5‐hydroxyindoleacetic acid (5‐HIAA), may depend on plasma concentrations of the essential amino acid L‐tryptophan (TRP), which is investigated in normal volunteers undergoing a 36‐h CSF collection via lumbar drain. Expand
Obsessive-compulsive disorder and serotonin: Is there a connection?
It is demonstrated that pharmacological blockade of serotonin reuptake alone is not sufficient for an antiobsessional response. Expand
Linkage of antisocial alcoholism to the serotonin 5-HT1B receptor gene in 2 populations.
Results suggest that a locus predisposing to antisocial alcoholism may be linked to HTR1B at 6q13-15. Expand
Dual origins of Finns revealed by Y chromosome haplotype variation.
Genetic evidence for the dual origins of Finns is presented by evaluating the pattern of Y chromosome variation in 280 unrelated males from nine Finnish provinces and revealing two major star-shaped clusters of Y haplotypes, indicative of a population expansion from two common Y chromosomes. Expand
Autosomal, mitochondrial, and Y chromosome DNA variation in Finland: evidence for a male-specific bottleneck.
Genetic evidence for a population bottleneck is identified by examining variable microsatellite loci on the nonrecombining portion of Y chromosomes from Finland and four populations from Europe and the Americas by examining sequence data from mtDNA and autosomal dinucleotide repeat markers. Expand
Obsessive-compulsive disorder. A double-blind trial of clomipramine and clorgyline.
Patients with obsessive-compulsive disorder who met DSM-III criteria and who had been ill for at least one year were studied in a double-blind, randomized, crossover comparison of the tricyclicExpand
Identification, expression, and pharmacology of a Cys23-Ser23 substitution in the human 5-HT2c receptor gene (HTR2C).
Concentration-response curves for 5-HT were not significantly different in oocytes expressing either form of the receptor, suggesting that the 5- HT2Ccys and5-HT2Cser receptor proteins may not differ in their responses to serotonin under baseline physiological conditions. Expand