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CYP3A4 gene

Known as: P450, FAMILY III, Cytochrome P450, Family 3, Subfamily A, Polypeptide 4 Gene, cytochrome P450 family 3 subfamily A member 4 
This gene plays an role in the metabolism of numerous clinically-relevant drugs. It is also involved in the oxidation of both endogenous substrates… Expand
National Institutes of Health

Related topics

Related topics

14 relations
CYP3A Gene LocusCYP3A4 wt AlleleCarcinogen MetabolismCytochrome P-450 CYP3A4
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Papers overview

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2019
2019
Evaluation of cytochrome P450 3A4‑mediated drug‑drug interaction potential between P2Y12 inhibitors and statins.
Ticagrelor and prasugrel are widely used in the treatment of acute coronary syndrome. The co‑administration of ticagrelor or… Expand
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2018
2018
Resemblance of the human liver sinusoid in a fluidic device with biomedical and pharmaceutical applications
Abstract Maintenance of the complex phenotype of primary hepatocytes in vitro represents a limitation for developing liver… Expand
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Review
2017
Review
2017
Analgesia and Opioids: A Pharmacogenetics Shortlist for Implementation in Clinical Practice.
BACKGROUND The use of opioids to alleviate pain is complicated by the risk of severe adverse events and the large variability in… Expand
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2015
2015
Evaluation of 89 compounds for identification of substrates for cynomolgus monkey CYP2C76, a new bupropion/nifedipine oxidase.
Cynomolgus monkeys are widely used in preclinical studies during drug development because of their evolutionary closeness to… Expand
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2014
2014
Modulation of CYP3a expression and activity in mice models of type 1 and type 2 diabetes
CYP3A4, the most abundant cytochrome P450 enzyme in the human liver and small intestine, is responsible for the metabolism of… Expand
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Highly Cited
2000
Highly Cited
2000
In vitro inhibition of human P450 enzymes by prenylated flavonoids from hops, Humulus lupulus
1. Several unique flavonoid compounds have recently been isolated from hops, Humulus lupulus, and their presence has been… Expand
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Highly Cited
1999
Highly Cited
1999
Identification and characterization of genes associated with human hepatocellular carcinogenesis.
Eight cDNAs encoding galectin 4 (Gal-4), UGT2B4 (UDP-glucuronosyltransferase), ribosomal phosphoprotein P0 (rpP0), dek, insulin… Expand
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1989
1989
The human cytochrome P450 CYP3 locus: assignment to chromosome 7q22-qter
SummaryThe cytochrome P-450s are a large multigene family of enzymes involved in the metabolism and detoxification of drugs and… Expand
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1988
1988
The gene CYP3 encoding P450pcn1 (nifedipine oxidase) is tightly linked to the gene COL1A2 encoding collagen type 1 alpha on 7q21-q22.1.
CYP3, the gene which encodes the hepatic cytochrome P450pcn1, the isozyme responsible for the metabolic oxidation of the calcium… Expand
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Highly Cited
1986
Highly Cited
1986
Characterization of rat and human liver microsomal cytochrome P-450 forms involved in nifedipine oxidation, a prototype for genetic polymorphism in oxidative drug metabolism.
The metabolism of the dihydropyridine calcium antagonist and vasodilator nifedipine has been reported to exhibit polymorphism… Expand
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