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CYP3A4 gene

Known as: P450, FAMILY III, Cytochrome P450, Family 3, Subfamily A, Polypeptide 4 Gene, cytochrome P450 family 3 subfamily A member 4 
This gene plays an role in the metabolism of numerous clinically-relevant drugs. It is also involved in the oxidation of both endogenous substrates… 
National Institutes of Health

Related topics

Related topics

14 relations
CYP3A Gene LocusCYP3A4 wt AlleleCarcinogen MetabolismCytochrome P-450 CYP3A4

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2019
2019
Evaluation of cytochrome P450 3A4‑mediated drug‑drug interaction potential between P2Y12 inhibitors and statins.
Ticagrelor and prasugrel are widely used in the treatment of acute coronary syndrome. The co‑administration of ticagrelor or… 
2005
2005
Characterization of human cytochrome P450 isoenzymes involved in the metabolism of vinorelbine
Vinorelbine (VRL) (IV Navelbine®) is a semi‐synthetic vinca alkaloid, used in therapeutics for the treatment of non‐small‐cell… 
2004
2004
The human cytochrome P450 CYP3 locus: assignment to chromosome 7q22-qter
SummaryThe cytochrome P-450s are a large multigene family of enzymes involved in the metabolism and detoxification of drugs and… 
2001
2001
Inhibitory Effect of Short-Term Bile Duct Ligation on Hepatic Cytochrome P450 of Bile Acid-Depleted Rats
In this study we analyzed the effect resulting from a short-term (1 h) bile duct obstruction in bile acid-depleted or… 
Highly Cited
2000
Highly Cited
2000
In vitro inhibition of human P450 enzymes by prenylated flavonoids from hops, Humulus lupulus
1. Several unique flavonoid compounds have recently been isolated from hops, Humulus lupulus, and their presence has been… 
Highly Cited
1999
Highly Cited
1999
Identification and characterization of genes associated with human hepatocellular carcinogenesis.
Eight cDNAs encoding galectin 4 (Gal-4), UGT2B4 (UDP-glucuronosyltransferase), ribosomal phosphoprotein P0 (rpP0), dek, insulin… 
1999
1999
Human, rat and crocodile liver microsomal monooxygenase activities measured using diazepam and nifedipine: effects of CYP3A inhibitors and relationship to immunochemically detected CYP3A apoprotein.
Highly Cited
1994
Highly Cited
1994
Characterization of the human gene (TBXAS1) encoding thromboxane synthase.
The gene encoding human thromboxane synthase (TBXAS1) was isolated from a human EMBL3 genomic library using human platelet… 
1988
1988
The gene CYP3 encoding P450pcn1 (nifedipine oxidase) is tightly linked to the gene COL1A2 encoding collagen type 1 alpha on 7q21-q22.1.
CYP3, the gene which encodes the hepatic cytochrome P450pcn1, the isozyme responsible for the metabolic oxidation of the calcium… 
Highly Cited
1986
Highly Cited
1986
Characterization of rat and human liver microsomal cytochrome P-450 forms involved in nifedipine oxidation, a prototype for genetic polymorphism in oxidative drug metabolism.
The metabolism of the dihydropyridine calcium antagonist and vasodilator nifedipine has been reported to exhibit polymorphism… 
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