CYP3A4 gene

Known as: P450, FAMILY III, Cytochrome P450, Family 3, Subfamily A, Polypeptide 4 Gene, cytochrome P450 family 3 subfamily A member 4 
This gene plays an role in the metabolism of numerous clinically-relevant drugs. It is also involved in the oxidation of both endogenous substrates… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1979-2017
0102019792017

Papers overview

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Highly Cited
2009
Highly Cited
2009
CYP3A4 metabolizes many drugs on the market. Although transcriptional regulation of CYP3A4 is known to be tightly controlled by… (More)
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2003
2003
CYP3A4, the predominant but variably expressed cytochrome P450 of adult human liver, is subject to multifaceted constitutive… (More)
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2003
2003
Cytochrome P450 3A4 (CYP3A4) is involved in the metabolism of more than 50% of currently used therapeutic drugs, yet the… (More)
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Highly Cited
2002
Highly Cited
2002
Cytochrome P450 3A4 (CYP3A4), the predominant P450 expressed in adult human liver, is both constitutively expressed and… (More)
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2002
2002
Three non-synonymous single nucleotide polymorphisms (SNPs) in the CYP3A4 gene were found in 34 cell lines derived from Japanese… (More)
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Highly Cited
2001
Highly Cited
2001
Although CYP3A induction by dexamethasone has been extensively documented, its mechanism is still unclear because both the role… (More)
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Highly Cited
1999
Highly Cited
1999
BACKGROUND There are large interindividual differences in CYP3A4 expression and in the metabolism of drug substrates for this… (More)
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Highly Cited
1998
Highly Cited
1998
The cytochrome P-450 monooxygenase 3A4 (CYP3A4) is responsible for the oxidative metabolism of a wide variety of xenobiotics… (More)
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Highly Cited
1998
Highly Cited
1998
BACKGROUND Pathways involved in androgen metabolism have been implicated in the etiology of prostate cancer. The goal of this… (More)
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Highly Cited
1993
Highly Cited
1993
CYP3 A4 is the adult-specific form of cytochrome P450 in human livers [Komori, M., Nishio, K., Kitada, M., Shiramatsu, K., Muroya… (More)
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