Semantic Scholar uses AI to extract papers important to this topic.
Ticagrelor and prasugrel are widely used in the treatment of acute coronary syndrome. The co‑administration of ticagrelor or… Expand Maintenance of the complex phenotype of primary hepatocytes in vitro represents a limitation for developing liver support systems… Expand BACKGROUND
The use of opioids to alleviate pain is complicated by the risk of severe adverse events and the large variability in… Expand Cynomolgus monkeys are widely used in preclinical studies during drug development because of their evolutionary closeness to… Expand CYP3A4, the most abundant cytochrome P450 enzyme in the human liver and small intestine, is responsible for the metabolism of… Expand SummaryThe cytochrome P-450s are a large multigene family of enzymes involved in the metabolism and detoxification of drugs and… Expand 1. Several unique flavonoid compounds have recently been isolated from hops, Humulus lupulus, and their presence has been… Expand Eight cDNAs encoding galectin 4 (Gal-4), UGT2B4 (UDP-glucuronosyltransferase), ribosomal phosphoprotein P0 (rpP0), dek, insulin… Expand CYP3, the gene which encodes the hepatic cytochrome P450pcn1, the isozyme responsible for the metabolic oxidation of the calcium… Expand The metabolism of the dihydropyridine calcium antagonist and vasodilator nifedipine has been reported to exhibit polymorphism… Expand