FAQ

CYP3A4 gene

Known as: P450, FAMILY III, Cytochrome P450, Family 3, Subfamily A, Polypeptide 4 Gene, cytochrome P450 family 3 subfamily A member 4 
This gene plays an role in the metabolism of numerous clinically-relevant drugs. It is also involved in the oxidation of both endogenous substrates… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1979-2017
0102019792017

Related topics

Related topics

14 relations
CYP3A Gene LocusCYP3A4 wt AlleleCarcinogen MetabolismCytochrome P-450 CYP3A4
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Related mentions per year

Related mentions per year

1936-2018
19401960198020002020
CYP3A4 gene
oxidation
Oxidation-Reduction
Metabolic Detoxication, Drug
Metabolism
fatty acid metabolism

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2009
Highly Cited
2009
MicroRNAs regulate CYP3A4 expression via direct and indirect targeting.
CYP3A4 metabolizes many drugs on the market. Although transcriptional regulation of CYP3A4 is known to be tightly controlled by… (More)
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2003
2003
Transgenic mouse models of human CYP3A4 gene regulation.
CYP3A4, the predominant but variably expressed cytochrome P450 of adult human liver, is subject to multifaceted constitutive… (More)
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2003
2003
Transcriptional regulation of human CYP3A4 basal expression by CCAAT enhancer-binding protein alpha and hepatocyte nuclear factor-3 gamma.
Cytochrome P450 3A4 (CYP3A4) is involved in the metabolism of more than 50% of currently used therapeutic drugs, yet the… (More)
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Highly Cited
2002
Highly Cited
2002
Transcriptional regulation of the human CYP3A4 gene by the constitutive androstane receptor.
Cytochrome P450 3A4 (CYP3A4), the predominant P450 expressed in adult human liver, is both constitutively expressed and… (More)
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2002
2002
CYP3A4 gene polymorphisms influence testosterone 6beta-hydroxylation.
Three non-synonymous single nucleotide polymorphisms (SNPs) in the CYP3A4 gene were found in 34 cell lines derived from Japanese… (More)
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Highly Cited
2001
Highly Cited
2001
Dual effect of dexamethasone on CYP3A4 gene expression in human hepatocytes. Sequential role of glucocorticoid receptor and pregnane X receptor.
Although CYP3A induction by dexamethasone has been extensively documented, its mechanism is still unclear because both the role… (More)
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Highly Cited
1999
Highly Cited
1999
Population distribution and effects on drug metabolism of a genetic variant in the 5' promoter region of CYP3A4.
BACKGROUND There are large interindividual differences in CYP3A4 expression and in the metabolism of drug substrates for this… (More)
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Highly Cited
1998
Highly Cited
1998
The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions.
The cytochrome P-450 monooxygenase 3A4 (CYP3A4) is responsible for the oxidative metabolism of a wide variety of xenobiotics… (More)
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Highly Cited
1998
Highly Cited
1998
Modification of clinical presentation of prostate tumors by a novel genetic variant in CYP3A4.
BACKGROUND Pathways involved in androgen metabolism have been implicated in the etiology of prostate cancer. The goal of this… (More)
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Highly Cited
1993
Highly Cited
1993
Gene structure of CYP3A4, an adult-specific form of cytochrome P450 in human livers, and its transcriptional control.
CYP3 A4 is the adult-specific form of cytochrome P450 in human livers [Komori, M., Nishio, K., Kitada, M., Shiramatsu, K., Muroya… (More)
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