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CYP3A4 gene

Known as: P450, FAMILY III, Cytochrome P450, Family 3, Subfamily A, Polypeptide 4 Gene, cytochrome P450 family 3 subfamily A member 4 
This gene plays an role in the metabolism of numerous clinically-relevant drugs. It is also involved in the oxidation of both endogenous substrates… Expand
National Institutes of Health

Papers overview

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2019
2019
Ticagrelor and prasugrel are widely used in the treatment of acute coronary syndrome. The co‑administration of ticagrelor or… Expand
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2018
2018
Abstract Maintenance of the complex phenotype of primary hepatocytes in vitro represents a limitation for developing liver… Expand
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Review
2017
Review
2017
BACKGROUND The use of opioids to alleviate pain is complicated by the risk of severe adverse events and the large variability in… Expand
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2015
2015
Cynomolgus monkeys are widely used in preclinical studies during drug development because of their evolutionary closeness to… Expand
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2014
2014
CYP3A4, the most abundant cytochrome P450 enzyme in the human liver and small intestine, is responsible for the metabolism of… Expand
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Highly Cited
2000
Highly Cited
2000
1. Several unique flavonoid compounds have recently been isolated from hops, Humulus lupulus, and their presence has been… Expand
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Highly Cited
1999
Highly Cited
1999
Eight cDNAs encoding galectin 4 (Gal-4), UGT2B4 (UDP-glucuronosyltransferase), ribosomal phosphoprotein P0 (rpP0), dek, insulin… Expand
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1989
1989
SummaryThe cytochrome P-450s are a large multigene family of enzymes involved in the metabolism and detoxification of drugs and… Expand
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1988
1988
CYP3, the gene which encodes the hepatic cytochrome P450pcn1, the isozyme responsible for the metabolic oxidation of the calcium… Expand
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Highly Cited
1986
Highly Cited
1986
The metabolism of the dihydropyridine calcium antagonist and vasodilator nifedipine has been reported to exhibit polymorphism… Expand
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