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CYP3A4 gene
Known as:
P450, FAMILY III
, Cytochrome P450, Family 3, Subfamily A, Polypeptide 4 Gene
, cytochrome P450 family 3 subfamily A member 4
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This gene plays an role in the metabolism of numerous clinically-relevant drugs. It is also involved in the oxidation of both endogenous substrates…
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National Institutes of Health
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Related topics
Related topics
14 relations
CYP3A Gene Locus
CYP3A4 wt Allele
Carcinogen Metabolism
Cytochrome P-450 CYP3A4
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Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2019
2019
Evaluation of cytochrome P450 3A4‑mediated drug‑drug interaction potential between P2Y12 inhibitors and statins.
B. Zhang
,
G. Zhan
,
+6 authors
Baoxin Li
Molecular medicine reports
2019
Corpus ID: 202731581
Ticagrelor and prasugrel are widely used in the treatment of acute coronary syndrome. The co‑administration of ticagrelor or…
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2018
2018
Resemblance of the human liver sinusoid in a fluidic device with biomedical and pharmaceutical applications
M. Ortega-Ribera
,
A. Fernández-Iglesias
,
+8 authors
J. Gracia‐Sancho
Biotechnology and bioengineering
2018
Corpus ID: 49421296
Maintenance of the complex phenotype of primary hepatocytes in vitro represents a limitation for developing liver support systems…
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Review
2017
Review
2017
Analgesia and Opioids: A Pharmacogenetics Shortlist for Implementation in Clinical Practice.
Maja Matic
,
S. D. de Wildt
,
D. Tibboel
,
R. V. van Schaik
Clinical chemistry
2017
Corpus ID: 8716331
BACKGROUND The use of opioids to alleviate pain is complicated by the risk of severe adverse events and the large variability in…
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2015
2015
Evaluation of 89 Compounds for Identification of Substrates for Cynomolgus Monkey CYP2C76, a New Bupropion/Nifedipine Oxidase
Shinya Hosaka
,
N. Murayama
,
+7 authors
H. Yamazaki
Drug Metabolism and Disposition
2015
Corpus ID: 22962356
Cynomolgus monkeys are widely used in preclinical studies during drug development because of their evolutionary closeness to…
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2014
2014
Modulation of CYP3a expression and activity in mice models of type 1 and type 2 diabetes
D. Patoine
,
M. Petit
,
S. Pilote
,
F. Picard
,
B. Drolet
,
C. Simard
Pharmacology research & perspectives
2014
Corpus ID: 5178548
CYP3A4, the most abundant cytochrome P450 enzyme in the human liver and small intestine, is responsible for the metabolism of…
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2004
2004
The human cytochrome P450 CYP3 locus: assignment to chromosome 7q22-qter
N. Spurr
,
A. Gough
,
K. Stevenson
,
C. Wolf
Human Genetics
2004
Corpus ID: 27115520
SummaryThe cytochrome P-450s are a large multigene family of enzymes involved in the metabolism and detoxification of drugs and…
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Highly Cited
2000
Highly Cited
2000
In vitro inhibition of human P450 enzymes by prenylated flavonoids from hops, Humulus lupulus
M. Henderson
,
C. Miranda
,
J. F. Stevens
,
M. Deinzer
,
D. Buhler
Xenobiotica; the fate of foreign compounds in…
2000
Corpus ID: 24209294
1. Several unique flavonoid compounds have recently been isolated from hops, Humulus lupulus, and their presence has been…
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Highly Cited
1999
Highly Cited
1999
Identification and characterization of genes associated with human hepatocellular carcinogenesis.
N. Kondoh
,
T. Wakatsuki
,
+10 authors
M. Yamamoto
Cancer research
1999
Corpus ID: 15395605
Eight cDNAs encoding galectin 4 (Gal-4), UGT2B4 (UDP-glucuronosyltransferase), ribosomal phosphoprotein P0 (rpP0), dek, insulin…
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1988
1988
The gene CYP3 encoding P450pcn1 (nifedipine oxidase) is tightly linked to the gene COL1A2 encoding collagen type 1 alpha on 7q21-q22.1.
B. Brooks
,
O. Mcbride
,
+4 authors
J. Idle
American journal of human genetics
1988
Corpus ID: 22829030
CYP3, the gene which encodes the hepatic cytochrome P450pcn1, the isozyme responsible for the metabolic oxidation of the calcium…
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Highly Cited
1986
Highly Cited
1986
Characterization of rat and human liver microsomal cytochrome P-450 forms involved in nifedipine oxidation, a prototype for genetic polymorphism in oxidative drug metabolism.
F. Guengerich
,
M. Martín
,
P. Beaune
,
P. Kremers
,
T. Wolff
,
D. Waxman
The Journal of biological chemistry
1986
Corpus ID: 5570007
The metabolism of the dihydropyridine calcium antagonist and vasodilator nifedipine has been reported to exhibit polymorphism…
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