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CYP3A4 gene

Known as: P450, FAMILY III, Cytochrome P450, Family 3, Subfamily A, Polypeptide 4 Gene, cytochrome P450 family 3 subfamily A member 4 
This gene plays an role in the metabolism of numerous clinically-relevant drugs. It is also involved in the oxidation of both endogenous substrates… 
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2019
2019
Ticagrelor and prasugrel are widely used in the treatment of acute coronary syndrome. The co‑administration of ticagrelor or… 
2018
2018
Maintenance of the complex phenotype of primary hepatocytes in vitro represents a limitation for developing liver support systems… 
Review
2017
Review
2017
BACKGROUND The use of opioids to alleviate pain is complicated by the risk of severe adverse events and the large variability in… 
2015
2015
Cynomolgus monkeys are widely used in preclinical studies during drug development because of their evolutionary closeness to… 
2014
2014
CYP3A4, the most abundant cytochrome P450 enzyme in the human liver and small intestine, is responsible for the metabolism of… 
2004
2004
SummaryThe cytochrome P-450s are a large multigene family of enzymes involved in the metabolism and detoxification of drugs and… 
Highly Cited
2000
Highly Cited
2000
1. Several unique flavonoid compounds have recently been isolated from hops, Humulus lupulus, and their presence has been… 
Highly Cited
1999
Highly Cited
1999
Eight cDNAs encoding galectin 4 (Gal-4), UGT2B4 (UDP-glucuronosyltransferase), ribosomal phosphoprotein P0 (rpP0), dek, insulin… 
1988
1988
CYP3, the gene which encodes the hepatic cytochrome P450pcn1, the isozyme responsible for the metabolic oxidation of the calcium… 
Highly Cited
1986
Highly Cited
1986
The metabolism of the dihydropyridine calcium antagonist and vasodilator nifedipine has been reported to exhibit polymorphism…