• Publications
  • Influence
P450 superfamily: update on new sequences, gene mapping, accession numbers and nomenclature.
TLDR
This revision supersedes the four previous updates in which a nomenclature system, based on divergent evolution of the P450 superfamily has been described and is similar to that proposed in the previous updates.
An essential role for nuclear receptors SXR/PXR in detoxification of cholestatic bile acids
TLDR
It is shown that activation of SXR/PXR is necessary and sufficient to both induce CYP3A enzymes and confer resistance to toxicity by LCA, as well as other xenotoxicants such as tribromoethanol and zoxazolamine.
Requirement of STAT5b for sexual dimorphism of body growth rates and liver gene expression.
TLDR
The requirement of STAT5b to maintain sexual dimorphism of body growth rates and liver gene expression suggests thatSTAT5b may be the major, if not the sole, STAT protein that mediates the sexually dimorphic effects of GH pulses in liver and perhaps other target tissues.
MAnorm: a robust model for quantitative comparison of ChIP-Seq data sets
TLDR
A simple and effective method, MAnorm, is presented for quantitative comparison of ChIP-Seq data sets describing transcription factor binding sites and epigenetic modifications and showed strong correlation with both the changes in expression of target genes and the binding of cell type-specific regulators.
P450 gene induction by structurally diverse xenochemicals: central role of nuclear receptors CAR, PXR, and PPAR.
  • D. Waxman
  • Biology, Chemistry
    Archives of biochemistry and biophysics
  • 1 September 1999
TLDR
P450 induction by xenobiotics may in some cases lead to a perturbation of endogenous regulatory circuits with associated pathophysiological consequences, leading to the proposal that these receptors may primarily serve to modulate hepatic P450 activity in response to endogenous dietary or hormonal stimuli.
The P450 superfamily: update on new sequences, gene mapping, accession numbers, early trivial names of enzymes, and nomenclature.
TLDR
The likelihood that this ancient gene superfamily has existed for more than 3.5 billion years, and that the rate of P450 gene evolution appears to be quite nonlinear, is discussed.
Growth hormone regulation of sex-dependent liver gene expression.
TLDR
The mechanisms whereby GH, via its sex-dependent temporal patterns of pituitary release, activates intracellular signaling leading to the sexually dimorphic transcription of CYPs and other liver-expressed genes are examined.
Activation of PPARα and PPARγ by Environmental Phthalate Monoesters
TLDR
The potential of environmental phthalate monoesters for activation of rodent and human PPARs is demonstrated and may help to elucidate the molecular basis for the adverse health effects proposed to be associated with humanphthalate exposure.
Evaluation of triacetyloleandomycin, alpha-naphthoflavone and diethyldithiocarbamate as selective chemical probes for inhibition of human cytochromes P450.
TLDR
Evaluating directly the P450 form selectivity of TAO, ANF, and DDC establishes that TAO is a selective inhibitor of the human CYP3A subfamily and that DDC cannot be employed as a diagnostic inhibitory probe for CYP2E1.
Differential activation of cyclophosphamide and ifosphamide by cytochromes P-450 2B and 3A in human liver microsomes.
TLDR
It is established that liver microsomal CYP2B and CYP3A preferentially catalyze cyclophosphamide and ifosphamide 4-hydroxylation, respectively, suggesting that liver P-450-inducing agents targeted at these enzymes might be used in cancer patients to enhance drug activation and therapeutic efficacy.
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