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- Publications
- Influence
Antiproliferative and cytotoxic effects of prenylated flavonoids from hops (Humulus lupulus) in human cancer cell lines.
- C. Miranda, J. Stevens, +6 authors D. Buhler
- Chemistry, Medicine
- Food and chemical toxicology : an international…
- 1 April 1999
Six flavonoids [xanthohumol (XN), 2',4',6',4-tetrahydroxy-3'-prenylchalcone (TP); 2',4',6',4-tetrahydroxy-3'-geranylchalcone (TG); dehydrocycloxanthohumol (DX); dehydrocycloxanthohumol hydrate (DH);… Expand
Constitutive and xenobiotics-induced expression of a novel CYP3A gene from zebrafish larva.
- Hua-Pin Tseng, T. Hseu, D. Buhler, W. Wang, Chin-Hwa Hu
- Biology, Medicine
- Toxicology and applied pharmacology
- 15 June 2005
In mammals, CYP3A isozymes collectively comprise the largest portion of the liver and small intestinal CYP protein. They are involved in the metabolism of an extensive range of endogenous substrates… Expand
Species differences in the hepatic microsomal enzyme metabolism of the pyrrolizidine alkaloids.
- J. Huan, C. Miranda, D. Buhler, P. Cheeke
- Biology, Medicine
- Toxicology letters
- 15 October 1998
Species differences in pyrrolic metabolites and senecionine (SN) N-oxide formation among eight animal species (sheep, cattle, gerbils, rabbits, hamsters, Japanese quail, chickens, rats) varying in… Expand
Antioxidant and prooxidant actions of prenylated and nonprenylated chalcones and flavanones in vitro.
- C. Miranda, J. Stevens, +4 authors D. Buhler
- Chemistry, Medicine
- Journal of agricultural and food chemistry
- 21 July 2000
Prenylated flavonoids found in hops and beer, i.e., prenylchalcones and prenylflavanones, were examined for their ability to inhibit in vitro oxidation of human low-density lipoprotein (LDL). The… Expand
Conservation of gene expression signatures between zebrafish and human liver tumors and tumor progression
- S. H. Lam, Y. L. Wu, +11 authors Zhiyuan Gong
- Biology, Medicine
- Nature Biotechnology
- 2006
The zebrafish (Danio rerio) has been long advocated as a model for cancer research, but little is known about the real molecular similarities between zebrafish and human tumors. Comparative analysis… Expand
In vitro inhibition of human P450 enzymes by prenylated flavonoids from hops, Humulus lupulus
- M. Henderson, C. Miranda, J. Stevens, M. Deinzer, D. Buhler
- Chemistry, Medicine
- Xenobiotica; the fate of foreign compounds in…
- 1 January 2000
1. Several unique flavonoid compounds have recently been isolated from hops, Humulus lupulus, and their presence has been detected in beer. Their chemical structures are similar to other… Expand
Rainbow trout cytochrome P450s: purification, molecular aspects, metabolic activity, induction and role in environmental monitoring.
- D. Buhler, J. Wang-Buhler
- Chemistry, Biology
- Comparative biochemistry and physiology. Part C…
- 1 November 1998
Cytochromes P450 (P450s or CYPs) constitute a superfamily of heme-thiolate proteins that play important roles in oxidative metabolism of endogenous and exogenous compounds. This review provides some… Expand
Mechanisms of the antiangiogenic activity by the hop flavonoid xanthohumol: NF‐κB and Akt as targets
- A. Albini, R. Dell’eva, +4 authors G. Fassina
- Chemistry, Medicine
- FASEB journal : official publication of the…
- 1 March 2006
Xanthohumol (XN), the principal flavonoid of the hop plant (Humulus lupulus L.) and a constituent of beer, has been suggested to have potential cancer chemopreventive activities. We have observed… Expand
Status and opportunities for genomics research with rainbow trout.
- G. Thorgaard, G. Bailey, +16 authors Y. Palti
- Biology, Medicine
- Comparative biochemistry and physiology. Part B…
- 1 December 2002
The rainbow trout (Oncorhynchus mykiss) is one of the most widely studied of model fish species. Extensive basic biological information has been collected for this species, which because of their… Expand
CYP3C1, the first member of a new cytochrome P450 subfamily found in zebrafish (Danio rerio).
- G. Corley-Smith, Hsiao-Ting Su, +5 authors D. Buhler
- Biology, Medicine
- Biochemical and biophysical research…
- 24 February 2006
We report a new cytochrome P450 (CYP) subfamily CYP3C and the cloning through PCR from zebrafish (Danio rerio) of the first member, CYP3C1. The CYP3C1 gene is on Chromosome 3 with 13 ORF exons… Expand