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Antiproliferative and cytotoxic effects of prenylated flavonoids from hops (Humulus lupulus) in human cancer cell lines.
Constitutive and xenobiotics-induced expression of a novel CYP3A gene from zebrafish larva.
In vitro inhibition of human P450 enzymes by prenylated flavonoids from hops, Humulus lupulus
- M. Henderson, C. Miranda, J. F. Stevens, M. Deinzer, D. Buhler
- Biology, ChemistryXenobiotica; the fate of foreign compounds in…
- 1 January 2000
It is suggested that the hop flavonoids are potent and selective inhibitors of human cytochrome P450 and warrant further in vivo investigations.
Species differences in the hepatic microsomal enzyme metabolism of the pyrrolizidine alkaloids.
Antioxidant and prooxidant actions of prenylated and nonprenylated chalcones and flavanones in vitro.
- C. Miranda, J. F. Stevens, D. Buhler
- Chemistry, BiologyJournal of agricultural and food chemistry
- 21 July 2000
It is suggested that prenylchalcones and prenylflavanones found in hops and beer protect human LDL from oxidation and thatPrenylation antagonizes the prooxidant effects of the chalcone, CN, and the flavanone, NG.
Conservation of gene expression signatures between zebrafish and human liver tumors and tumor progression
Comparative analysis of microarray data from zebrafish liver tumors with those from four human tumor types revealed molecular conservation at various levels between fish and human tumors, providing a useful strategy for identifying an expression signature that is strongly associated with a disease phenotype.
Mechanisms of the antiangiogenic activity by the hop flavonoid xanthohumol: NF‐κB and Akt as targets
It is shown for the first time that XN can inhibit growth of a vascular tumor in vivo and the mechanisms for its inhibition of angiogenesis in vitro and related endothelial cell activities in vitro.
Status and opportunities for genomics research with rainbow trout.
Rainbow trout cytochrome P450s: purification, molecular aspects, metabolic activity, induction and role in environmental monitoring.
Evaluation of chemicals as inhibitors of trout cytochrome P450s.
- C. Miranda, M. Henderson, D. Buhler
- Biology, ChemistryToxicology and applied pharmacology
- 1 February 1998
The results of this study suggest that inhibition data from mammalian studies could not be directly extrapolated to trout and likely other fish species and that care must be observed when mammalian P450 inhibitors are used to determine the participation of P450s in the metabolism and toxicity of xenobiotics in nonmammalian species.