C. Miranda | Semantic Scholar

Antiproliferative and cytotoxic effects of prenylated flavonoids from hops (Humulus lupulus) in human cancer cell lines.

C. Miranda, J. F. Stevens, D. Buhler
Chemistry, Biology
Food and chemical toxicology : an international…
1 April 1999

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In vitro inhibition of human P450 enzymes by prenylated flavonoids from hops, Humulus lupulus

M. Henderson, C. Miranda, J. F. Stevens, M. Deinzer, D. Buhler
Biology, Chemistry
Xenobiotica; the fate of foreign compounds in…
1 January 2000

It is suggested that the hop flavonoids are potent and selective inhibitors of human cytochrome P450 and warrant further in vivo investigations.

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Species differences in the hepatic microsomal enzyme metabolism of the pyrrolizidine alkaloids.

J. Huan, C. Miranda, D. Buhler, P. Cheeke
Chemistry, Biology
Toxicology letters
15 October 1998

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Antioxidant and prooxidant actions of prenylated and nonprenylated chalcones and flavanones in vitro.

C. Miranda, J. F. Stevens, D. Buhler
Chemistry, Biology
Journal of agricultural and food chemistry
21 July 2000

It is suggested that prenylchalcones and prenylflavanones found in hops and beer protect human LDL from oxidation and thatPrenylation antagonizes the prooxidant effects of the chalcone, CN, and the flavanone, NG.

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Pharmacokinetics of xanthohumol and metabolites in rats after oral and intravenous administration.

Leecole L Legette, Lianxue Ma, J. Stevens
Biology, Medicine
Molecular nutrition & food research
1 March 2012

The bioavailability of XN is dose-dependent and approximately 0.33, 0.13, and 0.11 in rats, for the low, medium, and high-dose groups, respectively.

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Xanthohumol and related prenylated flavonoids inhibit inflammatory cytokine production in LPS-activated THP-1 monocytes: structure-activity relationships and in silico binding to myeloid…

M. R. Peluso, C. Miranda, D. Hobbs, Rosita R. Proteau, J. F. Stevens
Biology, Chemistry
Planta medica
22 March 2010

Prenylated flavonoids may suppress LPS-inducedTLR4 activation at least partly by interfering with LPS binding to the TLR4 coreceptor MD-2, and XN exerts an additional anti-inflammatory effect by downregulating the cellular TLR 4 protein content.

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Xanthohumol, a prenylflavonoid derived from hops induces apoptosis and inhibits NF-kappaB activation in prostate epithelial cells.

Emily Colgate, C. Miranda, J. Stevens, T. Bray, E. Ho
Biology
Cancer letters
8 February 2007

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Evaluation of chemicals as inhibitors of trout cytochrome P450s.

C. Miranda, M. Henderson, D. Buhler
Biology, Chemistry
Toxicology and applied pharmacology
1 February 1998

The results of this study suggest that inhibition data from mammalian studies could not be directly extrapolated to trout and likely other fish species and that care must be observed when mammalian P450 inhibitors are used to determine the participation of P450s in the metabolism and toxicity of xenobiotics in nonmammalian species.

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Role of cytochrome P450IIIA4 in the metabolism of the pyrrolizidine alkaloid senecionine in human liver.

C. Miranda, R. Reed, F. Guengerich, D. Buhler
Biology, Chemistry
Carcinogenesis
1 March 1991

Evidence is provided that P450IIIA4 is the major enzyme catalyzing the bioactivation (DHP formation) and detoxication (senecionine N-oxide formation) of senECionine in human liver.

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Identification and in vitro biological activities of hop proanthocyanidins: inhibition of nNOS activity and scavenging of reactive nitrogen species.

J. F. Stevens, C. Miranda, K. Wolthers, M. Schimerlik, M. Deinzer, D. Buhler
Biology, Chemistry
Journal of agricultural and food chemistry
8 May 2002

The hop oligomeric proanthocyanidins (PC) were found to be potent inhibitors of neuronal nitric oxide synthase (nNOS) activity and the catechin trimer (TR) exhibited antioxidant activity more than 1 order of magnitude greater than that of alpha-tocopherol or ascorbic acid on a molar basis.

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