J. F. Stevens | Semantic Scholar

Vitamins C and E: beneficial effects from a mechanistic perspective.

M. Traber, J. F. Stevens
Biology
Free radical biology & medicine
1 September 2011

Acrolein: sources, metabolism, and biomolecular interactions relevant to human health and disease.

J. F. Stevens, C. Maier
Biology, Chemistry
Molecular nutrition & food research
2008

The biological effects of acrolein are a consequence of its reactivity towards biological nucleophiles such as guanine in DNA and cysteine, lysine, histidine, and arginine residues in critical regions of nuclear factors, proteases, and other proteins.

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Xanthohumol and related prenylflavonoids from hops and beer: to your good health!

J. F. Stevens, J. Page
Chemistry, Biology
Phytochemistry
1 May 2004

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Quantitative analysis of xanthohumol and related prenylflavonoids in hops and beer by liquid chromatography-tandem mass spectrometry.

J. F. Stevens, A. W. Taylor, M. Deinzer
Chemistry
Journal of chromatography. A
5 January 1999

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Antiproliferative and cytotoxic effects of prenylated flavonoids from hops (Humulus lupulus) in human cancer cell lines.

C. Miranda, J. F. Stevens, D. Buhler
Chemistry, Biology
Food and chemical toxicology : an international…
1 April 1999

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EST Analysis of Hop Glandular Trichomes Identifies an O-Methyltransferase That Catalyzes the Biosynthesis of Xanthohumol[W][OA]

Jana Nagel, L. Culley, J. Page
Chemistry
The Plant Cell Online
1 January 2008

The lupulin gland-specific EST data set expands the genomic resources for H. lupulus and provides further insight into the metabolic specialization of glandular trichomes.

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In vitro inhibition of human P450 enzymes by prenylated flavonoids from hops, Humulus lupulus

M. Henderson, C. Miranda, J. F. Stevens, M. Deinzer, D. Buhler
Biology, Chemistry
Xenobiotica; the fate of foreign compounds in…
1 January 2000

It is suggested that the hop flavonoids are potent and selective inhibitors of human cytochrome P450 and warrant further in vivo investigations.

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Fate of xanthohumol and related prenylflavonoids from hops to beer.

J. F. Stevens, A. W. Taylor, J. Clawson, M. Deinzer
Chemistry
Journal of agricultural and food chemistry
30 April 1999

Solubility experiments indicated that (1) malt carbohydrates form soluble complexes with xanthohumol and isoxanthohumsol and (2) solubility does not dictate the isxanthohUMol levels of finished beers.

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Antioxidant and prooxidant actions of prenylated and nonprenylated chalcones and flavanones in vitro.

C. Miranda, J. F. Stevens, D. Buhler
Chemistry, Biology
Journal of agricultural and food chemistry
21 July 2000

It is suggested that prenylchalcones and prenylflavanones found in hops and beer protect human LDL from oxidation and thatPrenylation antagonizes the prooxidant effects of the chalcone, CN, and the flavanone, NG.

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Xanthohumol and related prenylated flavonoids inhibit inflammatory cytokine production in LPS-activated THP-1 monocytes: structure-activity relationships and in silico binding to myeloid…

M. R. Peluso, C. Miranda, D. Hobbs, Rosita R. Proteau, J. F. Stevens
Biology, Chemistry
Planta medica
22 March 2010

Prenylated flavonoids may suppress LPS-inducedTLR4 activation at least partly by interfering with LPS binding to the TLR4 coreceptor MD-2, and XN exerts an additional anti-inflammatory effect by downregulating the cellular TLR 4 protein content.

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