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Acrolein: sources, metabolism, and biomolecular interactions relevant to human health and disease.
TLDR
The biological effects of acrolein are a consequence of its reactivity towards biological nucleophiles such as guanine in DNA and cysteine, lysine, histidine, and arginine residues in critical regions of nuclear factors, proteases, and other proteins. Expand
Vitamins C and E: beneficial effects from a mechanistic perspective.
TLDR
Mechanism-based effects of vitamin C and E supplementation on biomarkers and on clinical outcomes from randomized, placebo-controlled trials are emphasized in this review. Expand
Xanthohumol and related prenylflavonoids from hops and beer: to your good health!
TLDR
Biological activities suggest that prenylflavonoids from hops have potential for application in cancer prevention programs and in prevention or treatment of (post-)menopausal 'hot flashes' and osteoporosis. Expand
Quantitative analysis of xanthohumol and related prenylflavonoids in hops and beer by liquid chromatography-tandem mass spectrometry.
TLDR
Isoxanthohumol was the most abundant flavonoid in hopped beers, ranging from 0.04 to 3.44 mg/l, and the accuracy and precision were evaluated by replicate analyses of (spiked) samples. Expand
Antiproliferative and cytotoxic effects of prenylated flavonoids from hops (Humulus lupulus) in human cancer cell lines.
TLDR
Six flavonoids from hops tested for their antiproliferative activity in human breast cancer, colon cancer and ovarian cancer cells in vitro indicated that XN (chalcone) and IX (flavanone isomer of XN) may have potential chemopreventive activity against breast and ovariancancer in humans. Expand
EST Analysis of Hop Glandular Trichomes Identifies an O-Methyltransferase That Catalyzes the Biosynthesis of Xanthohumol[W][OA]
TLDR
The lupulin gland-specific EST data set expands the genomic resources for H. lupulus and provides further insight into the metabolic specialization of glandular trichomes. Expand
Antioxidant and prooxidant actions of prenylated and nonprenylated chalcones and flavanones in vitro.
TLDR
It is suggested that prenylchalcones and prenylflavanones found in hops and beer protect human LDL from oxidation and thatPrenylation antagonizes the prooxidant effects of the chalcone, CN, and the flavanone, NG. Expand
In vitro inhibition of human P450 enzymes by prenylated flavonoids from hops, Humulus lupulus
TLDR
It is suggested that the hop flavonoids are potent and selective inhibitors of human cytochrome P450 and warrant further in vivo investigations. Expand
Fate of xanthohumol and related prenylflavonoids from hops to beer.
TLDR
Solubility experiments indicated that (1) malt carbohydrates form soluble complexes with xanthohumol and isoxanthohumsol and (2) solubility does not dictate the isxanthohUMol levels of finished beers. Expand
Xanthohumol and related prenylated flavonoids inhibit inflammatory cytokine production in LPS-activated THP-1 monocytes: structure-activity relationships and in silico binding to myeloid
TLDR
Prenylated flavonoids may suppress LPS-inducedTLR4 activation at least partly by interfering with LPS binding to the TLR4 coreceptor MD-2, and XN exerts an additional anti-inflammatory effect by downregulating the cellular TLR 4 protein content. Expand
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