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Cytochrome P-450 CYP3A4

Known as: Taurochenodeoxycholate 6-alpha-Monooxygenase, 6-alpha-Monooxygenase, Taurochenodeoxycholate, Cytochrome P450 3A4 
A specific subtype of CYP3A.
National Institutes of Health

Related topics

Related topics

4 relations
CYP3A4 genetaurochenodeoxycholate 6alpha-hydroxylase activity

Broader (1)

cytochrome P450 3A

Narrower (1)

cytochrome P450 3A4 protein, human

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2018
2018
A feasibility study of the toxic responses of human induced pluripotent stem cell-derived hepatocytes to phytochemicals.
2014
2014
Expression and Characterization of Cynomolgus Monkey Cytochrome CYP3A4 in a Novel Human Embryonic Kidney Cell–Based Mammalian System
Cynomolgus monkeys are a commonly used species in preclinical drug discovery, and have high genetic similarity to humans… 
2012
2012
Establishment of a stable human cell line, HPL-A3, for use in reporter gene assays of cytochrome P450 3A inducers.
We have established a stable human cell line, termed HPL-A3, by co-transfection of a human pregnane X receptor (hPXR) expression… 
2010
2010
Composition comprising bi-1 protein for reducing the induced drug toxicity caused by the decreased activity of cytochrome p450 3a4 and the use thereof
PURPOSE: A composition containing BI-1 protein is provided to enhance activity of cytochrome p450 3A4(CYP3A4) and reduce drug… 
2010
2010
Gene expression of P-glycoprotein and cytochrome P450 3A4 in peripheral blood mononuclear cells and correlation with expression in liver.
2006
2006
[Effects of chronic HBV infection on human hepatic cytochrome P450 3A4].
OBJECTIVE To study the effect of HBV on human hepatic cytochrome P450 3A4 (CYP3A4) in patients with chronic HBV infection… 
2006
2006
PIII‐62
2006
2006
Small interfering RNA mediated silencing of cytochrome P450 3A4 gene
Objective To investigate the inhibitory effect of the cytochrome P450 3A4(CYP3A4) gene expression and function in CHL-3A4 cells… 
Highly Cited
2006
Highly Cited
2006
MDR1 genotype is associated with hepatic cytochrome P450 3A4 basal and induction phenotype
Highly Cited
2004
Highly Cited
2004
Allelic expression imbalance of the human CYP3A4 gene and individual phenotypic status.
The human cytochrome P450 3A4 (CYP3A4) plays a dominant role in the metabolism of numerous clinically useful drugs. Alterations… 
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