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cytochrome P450 3A4 protein, human

Known as: Cytochrome P450 HLp, P450, FAMILY III, EC 1.14.13.67 
Cytochrome P450 3A4 (503 aa, ~57 kDa) is encoded by the human CYP3A4 gene. This protein is involved in the oxidation of steroids, fatty acids and… Expand
National Institutes of Health

Papers overview

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Highly Cited
2009
Highly Cited
2009
Members of the cytochrome P450 (P450) enzyme families CYP1, CYP2, and CYP3 are responsible for the metabolism of approximately 75… Expand
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Highly Cited
2008
Highly Cited
2008
The aim of the present study was to estimate the relative contribution of cytochrome P450 isoforms (P450s), including P450s of… Expand
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Highly Cited
2008
Highly Cited
2008
Human microsomal cytochrome P-450 2E1 (CYP2E1) monooxygenates >70 low molecular weight xenobiotic compounds, as well as much… Expand
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Highly Cited
1999
Highly Cited
1999
Different roles of individual forms of human cytochrome P-450 (CYP) in the oxidation of 7-ethoxycoumarin and chlorzoxazone were… Expand
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Highly Cited
1999
Highly Cited
1999
The nonsteroidal anti-inflammatory drug diclofenac causes a rare but potentially fatal hepatotoxicity that may be associated with… Expand
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Highly Cited
1998
Highly Cited
1998
Grapefruit juice has been found to significantly increase oral bioavailability of several drugs metabolized by cytochrome P450… Expand
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Highly Cited
1992
Highly Cited
1992
Rat and human lung microsomal cytochrome P-450 (P-450) enzymes have been characterized with regard to their catalytic activities… Expand
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Highly Cited
1991
Highly Cited
1991
The enzyme sterol 27-hydroxylase catalyzes the first step in the oxidation of the side chain of sterol intermediates in the bile… Expand
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Highly Cited
1989
Highly Cited
1989
In vitro studies with human liver indicate that the major catalyst involved in the bioactivation of the hepato-carcinogen… Expand
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Review
1989
Review
1989
  • F. Guengerich
  • Annual review of pharmacology and toxicology
  • 1989
  • Corpus ID: 43810514
Cytochrome P-4501 enzymes catalyze the oxidation of a wide variety of drugs, pesticides, carcinogens, toxicants, pollutants, and… Expand
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