cytochrome P450 3A4 protein, human

Known as: Cytochrome P450 HLp, P450, FAMILY III, EC 1.14.13.67 
Cytochrome P450 3A4 (503 aa, ~57 kDa) is encoded by the human CYP3A4 gene. This protein is involved in the oxidation of steroids, fatty acids and… (More)
National Institutes of Health

Papers overview

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Highly Cited
2009
Highly Cited
2009
Members of the cytochrome P450 (P450) enzyme families CYP1, CYP2, and CYP3 are responsible for the metabolism of approximately 75… (More)
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2005
2005
Cytochrome P450 1A1 (CYP1A1) is one of the most important enzymes implicated in the metabolic activation of carcinogens. To date… (More)
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Highly Cited
2002
Highly Cited
2002
Diets enriched in docosahexaenoic acid, a major n-3 fatty acid in fish oil, have hypotensive properties. One mechanism that can… (More)
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Highly Cited
1999
Highly Cited
1999
The nonsteroidal anti-inflammatory drug diclofenac causes a rare but potentially fatal hepatotoxicity that may be associated with… (More)
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1999
1999
The aim of this study was to evaluate the (3S)-3-hydroxylation and the N-oxidation of quinidine as biomarkers for cytochrome P… (More)
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1998
1998
Porphyria cutanea tarda is associated with excess hepatic production of uroporphyrin. Oxidation of uroporphyrinogen to… (More)
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Review
1996
Review
1996
As a participant of the endogenous arachidonic acid metabolic cascade, microsomal cytochrome P450 metabolizes the fatty acid to… (More)
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Highly Cited
1992
Highly Cited
1992
Rat and human lung microsomal cytochrome P-450 (P-450) enzymes have been characterized with regard to their catalytic activities… (More)
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Highly Cited
1989
Highly Cited
1989
In vitro studies with human liver indicate that the major catalyst involved in the bioactivation of the hepato-carcinogen… (More)
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1989
1989
P-450NF is the major enzyme in human liver involved in the metabolism of the calcium-channel blocker nifedipine. By screening a… (More)
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