Cytochrome P450
- W. Backes, Benveniste, G. Strobl
- ChemistryHandbook of Experimental Pharmacology
- 1993
It is shown that in allylic hydroxyl ations (catalyzed by either model metalloporphyrins or cytochrome P450) rehydridization could occur to yield multiple products.
The CYP2D6 humanized mouse: effect of the human CYP2D6 transgene and HNF4alpha on the disposition of debrisoquine in the mouse.
- J. Corchero, C. Granvil, F. Gonzalez
- Biology, MedicineMolecular Pharmacology
- 1 December 2001
The data presented in this study show that only CYP2D6 humanized mice but not wild-type mice display significant DEB 4-hydroxylase activity and that HNF4alpha regulates CYP1D6 activity in vivo.
Nomenclature for human CYP2D6 alleles.
- A. Daly, J. Brockmöller, U. M. Zanger
- BiologyPharmacogenetics (London)
- 1 June 1996
It is proposed that alleles be designated by CYP2D6 followed by an asterisk and a combination of roman letters and arabic numerals distinct for each allele with the number specifying the key mutation and, where appropriate, a letter specifying additional mutations.
METABOLISM OF MELATONIN BY HUMAN CYTOCHROMES P450
- Xiaochao Ma, J. Idle, K. Krausz, F. Gonzalez
- BiologyDrug Metabolism And Disposition
- 1 April 2005
Comparison of brain homogenates from wild-type and cyp1b1-null mice revealed that MEL 6-hydroxylation was clearly mediated to a significant degree by CYP1B1, the first time that CYP 1B1 has been shown to 6-Hydroxylate MEL.
Detection of the poor metabolizer-associated CYP2D6(D) gene deletion allele by long-PCR technology.
- V. Steen, O. Andreassen, A. Gulbrandsen
- BiologyPharmacogenetics (London)
- 1 August 1995
A rapid assay which, for the first time, detects the 13kb Xba I gene deletion allele by the use of long-PCR technology and will improve the scientific and clinical use of CYP2D6 genotyping.
The metabolomic window into hepatobiliary disease.
- D. BeyoÄŸlu, J. Idle
- Medicine, BiologyJournal of Hepatology
- 1 October 2013
A genetic polymorphism in coumarin 7-hydroxylation: sequence of the human CYP2A genes and identification of variant CYP2A6 alleles.
- P. Fernández-Salguero, S. Hoffman, J. Idle
- BiologyAmerican Journal of Human Genetics
- 1 September 1995
The existence of a new cytochrome P450 genetic polymorphism is established and variant alleles were found in individuals who were deficient in their ability to metabolize the CYP2A6 probe drug coumarin.
Serum metabolomics reveals irreversible inhibition of fatty acid beta-oxidation through the suppression of PPARalpha activation as a contributing mechanism of acetaminophen-induced hepatotoxicity.
- Chi Chen, K. Krausz, Y. Shah, J. Idle, F. Gonzalez
- BiologyChemical Research in Toxicology
- 3 March 2009
The serum metabolomics of APAP-induced hepatotoxicity revealed that the CYP2E1-mediated metabolic activation and oxidative stress following APAP treatment can cause irreversible inhibition of fatty acid oxidation, potentially through suppression of PPARalpha-regulated pathways.
POLYMORPHIC HYDROXYLATION OF DEBRISOQUINE IN MAN
- A. Mahgoub, L. Dring, J. Idle, R. Lancaster, R. Smith
- Medicine, ChemistryThe Lancet
- 17 September 1977
LC-MS-Based Metabolomics in Drug Metabolism
- Chi Chen, F. Gonzalez, J. Idle
- BiologyDrug metabolism reviews (Softcover ed.)
- 1 January 2007
In this review, the technological elements of LC- MS-based metabolomics for constructing high-quality datasets and conducting comprehensive data analysis are examined and four novel approaches of using LC-MS- based metabolomic techniques in xenobiotic metabolism research are proposed.
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