J. Idle

Publications341
h-index75
Citations18,372
Highly Influential Citations579
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Cytochrome P450
TLDR
It is shown that in allylic hydroxyl ations (catalyzed by either model metalloporphyrins or cytochrome P450) rehydridization could occur to yield multiple products. Expand
The CYP2D6 humanized mouse: effect of the human CYP2D6 transgene and HNF4alpha on the disposition of debrisoquine in the mouse.
TLDR
The data presented in this study show that only CYP2D6 humanized mice but not wild-type mice display significant DEB 4-hydroxylase activity and that HNF4alpha regulates CYP1D6 activity in vivo. Expand
Nomenclature for human CYP2D6 alleles.
TLDR
It is proposed that alleles be designated by CYP2D6 followed by an asterisk and a combination of roman letters and arabic numerals distinct for each allele with the number specifying the key mutation and, where appropriate, a letter specifying additional mutations. Expand
Serum metabolomics reveals irreversible inhibition of fatty acid beta-oxidation through the suppression of PPARalpha activation as a contributing mechanism of acetaminophen-induced hepatotoxicity.
TLDR
The serum metabolomics of APAP-induced hepatotoxicity revealed that the CYP2E1-mediated metabolic activation and oxidative stress following APAP treatment can cause irreversible inhibition of fatty acid oxidation, potentially through suppression of PPARalpha-regulated pathways. Expand
Detection of the poor metabolizer-associated CYP2D6(D) gene deletion allele by long-PCR technology.
TLDR
A rapid assay which, for the first time, detects the 13kb Xba I gene deletion allele by the use of long-PCR technology and will improve the scientific and clinical use of CYP2D6 genotyping. Expand
METABOLISM OF MELATONIN BY HUMAN CYTOCHROMES P450
TLDR
Comparison of brain homogenates from wild-type and cyp1b1-null mice revealed that MEL 6-hydroxylation was clearly mediated to a significant degree by CYP1B1, the first time that CYP 1B1 has been shown to 6-Hydroxylate MEL. Expand
The metabolomic window into hepatobiliary disease.
TLDR
The metabolomic window into hepatobiliary disease sheds new light on the systems pathology of the liver. Expand
A genetic polymorphism in coumarin 7-hydroxylation: sequence of the human CYP2A genes and identification of variant CYP2A6 alleles.
TLDR
The existence of a new cytochrome P450 genetic polymorphism is established and variant alleles were found in individuals who were deficient in their ability to metabolize the CYP2A6 probe drug coumarin. Expand
CYP2E1 genetic polymorphisms and risk of nasopharyngeal carcinoma in Taiwan.
TLDR
The findings suggest that the CYP2E1 genotype is a determinant of nasopharyngeal carcinoma risk. Expand
POLYMORPHIC HYDROXYLATION OF DEBRISOQUINE IN MAN
TLDR
Family studies supported the view that alicyclic 4-hydroxylation of debrisoquine is controlled by a single autosomal gene and that a defect in this metabolic step is caused by a recessive allele. Expand
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