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Free radical lipid peroxidation: mechanisms and analysis.
Mechanisms of free radical oxidation of unsaturated lipids
The mechanisms of these primary reaction steps has been the focus of extensive research over the past fifty years, and the current level of understanding of these transformations is the subject of this review.
Discovery of lipid peroxidation products formed in vivo with a substituted tetrahydrofuran ring (isofurans) that are favored by increased oxygen tension
- J. Fessel, N. Porter, K. Moore, J. Sheller, L. Roberts
- BiologyProceedings of the National Academy of Sciences…
- 13 December 2002
It is proposed that combined measurement of IsoFs and IsoPs should provide a more reliable index of oxidant stress severity than quantification of either alone because of the opposing modulation of the two pathways by oxygen tension, which can vary widely in different organs and disease states.
Control of oxygenation in lipoxygenase and cyclooxygenase catalysis.
Formation of Prostaglandins E2 and D2 via the Isoprostane Pathway
It is reported that compounds identical in all respects to PGE2 and PGD2 and their respective enantiomers are generated in vivo via the IsoP pathway, presumably by epimerization of racemic 15-E2t-IsoP and 15-D2c-I soP, respectively.
Two Distinct Pathways of Formation of 4-Hydroxynonenal
- C. Schneider, K. Tallman, N. Porter, A. Brash
- ChemistryThe Journal of Biological Chemistry
- 15 June 2001
Using the 9- and 13-hydroperoxides of linoleic acid as starting material, it is found that two distinct mechanisms lead to the formation of 4-H(P)NE and the corresponding 4-Hydro(pero)xyalkenal that retains the original carboxyl group.
Routes to 4-Hydroxynonenal: Fundamental Issues in the Mechanisms of Lipid Peroxidation*
Mechanistic evidence for non-enzymatic routes of fatty acid peroxyls, especially of the underappreciated intermolecular pathways that involve dimerized and oligomerized fatty acid derivatives as key intermediates are discussed.
Suggested mechanisms for the production of 4-hydroxy-2-nonenal from the autoxidation of polyunsaturated fatty acids.
Identification of protein targets of 4-hydroxynonenal using click chemistry for ex vivo biotinylation of azido and alkynyl derivatives.
- A. Vila, K. Tallman, A. Jacobs, D. Liebler, N. Porter, L. Marnett
- Biology, ChemistryChemical research in toxicology
- 31 January 2008
The use of azido and alkynyl derivatives in conjunction with click chemistry appears to be a valuable approach for the identification of the protein targets of HNE.